Results 31 to 40 of about 449,405 (356)
Acetylation in the regulation of autophagy
Autophagy, 2022 Post-translational modifications, such as phosphorylation, ubiquitination and acetylation, play crucial roles in the regulation of autophagy. Acetylation has emerged as an important regulatory mechanism for autophagy.
Yinfeng Xu, W. Wan
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Autophagy and autophagy signaling in Epilepsy: possible role of autophagy activator
Molecular Medicine, 2023 AbstractAutophagy is an explicit cellular process to deliver dissimilar cytoplasmic misfolded proteins, lipids and damaged organelles to the lysosomes for degradation and elimination. The mechanistic target of rapamycin (mTOR) is the main negative regulator of autophagy.
Naif H. Ali +7 more
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Autophagy and Autophagy-Related Diseases: A Review [PDF]
International Journal of Molecular Sciences, 2020 Autophagy refers to the process involving the decomposition of intracellular components via lysosomes. Autophagy plays an important role in maintaining and regulating cell homeostasis by degrading intracellular components and providing degradation products to cells.
Tadashi Ichimiya +8 more
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Current Biology, 2019 In 1955, the biologist and Nobel Prize laureate Christian de Duve discovered that cells possess specialized organelles filled with hydrolytic enzymes and he called these organelles lysosomes. At the same time, electron microscopy studies by Novikoff and colleagues showed that intracellular dense bodies, which later turned out to be lysosomes, contain ...
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ERMP1 Facilitates The Malignant Characteristics of Colorectal Cancer Cells through Modulating PI3K/AKT/β-Catenin Pathway and Localization of GRP78 [PDF]
Cell Journal, 2023 Objective: Endoplasmic reticulum-metallopeptidase 1 (ERMP1) is involved in cellular response to oxidative stress.However, its functional role in proliferation and progression of cancer cells remains unknown.
Nasim Rahmani-Kukia +2 more
doaj +1 more source
Autophagy and Noroviruses [PDF]
Viruses, 2019 Autophagy is an essential cellular process by which a cell degrades materials within its cytoplasm. Intracellular pathogens like viruses must deal with autophagy, either positively or negatively, for their own survival and replication. For some viruses, autophagy can even play proviral roles, helping their replication or dissemination.
Kevin Furlong, Seungmin Hwang
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Autophagy in major human diseases
EMBO Journal, 2021 Autophagy is a core molecular pathway for the preservation of cellular and organismal homeostasis. Pharmacological and genetic interventions impairing autophagy responses promote or aggravate disease in a plethora of experimental models.
D. Klionsky +58 more
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Frontiers in Endocrinology, 2019 Chronic consumption of high fat diets (HFDs), rich in saturated fatty acids (SatFAs) like palmitic acid (PA), is associated with the development of obesity and obesity-related metabolic diseases such as type II diabetes mellitus (T2DM).
María Paz Hernández-Cáceres +28 more
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The Autophagy Connection [PDF]
Developmental Cell, 2010 For a process intimately connected to an immense range of physiological processes, the molecular understanding of macroautophagy remains far from complete. Recent large-scale studies, including those of Behrends et al. in Nature and Lipinski et al. in Developmental Cell, are now providing new insight into the machinery of autophagy regulation.
Daniel J. Klionsky, Daniel J. Klionsky
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Journal of Biological Chemistry, 2007 Protein degradation by basal constitutive autophagy is important to avoid accumulation of polyubiquitinated protein aggregates and development of neurodegenerative diseases. The polyubiquitin-binding protein p62/SQSTM1 is degraded by autophagy.
Serhiy Pankiv +8 more
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