Results 31 to 40 of about 687,627 (397)
Autophagy: A cyto-protective mechanism which prevents primary human hepatocyte apoptosis during oxidative stress [PDF]
, 2012 The role of autophagy in the response of human hepatocytes to oxidative stress remains unknown. Understanding this process may have important implications for the understanding of basic liver epithelial cell biology and the responses of hepatocytes ...
Biederbick A +7 more
core +1 more source
Journal of Biological Chemistry, 2007 Protein degradation by basal constitutive autophagy is important to avoid accumulation of polyubiquitinated protein aggregates and development of neurodegenerative diseases. The polyubiquitin-binding protein p62/SQSTM1 is degraded by autophagy.
Serhiy Pankiv +8 more
semanticscholar +1 more source
Autophagy genes in biology and disease
Nature reviews genetics, 2023 Macroautophagy and microautophagy are highly conserved eukaryotic cellular processes that degrade cytoplasmic material in lysosomes. Both pathways involve characteristic membrane dynamics regulated by autophagy-related proteins and other molecules, some ...
Hayashi Yamamoto +2 more
semanticscholar +1 more source
Beyond self-eating: The control of nonautophagic functions and signaling pathways by autophagy-related proteins. [PDF]
, 2017 The identification of conserved autophagy-related proteins (ATGs) that mediate bulk degradation of cytosolic material laid the foundation for breakthroughs linking autophagy to a litany of physiological processes and disease conditions.
Cadwell, Ken, Debnath, Jayanta
core +1 more source
GPX4 in cell death, autophagy, and disease
Autophagy, 2023 Selenoprotein GPX4 (glutathione peroxidase 4), originally known as PHGPX (phospholipid hydroperoxide glutathione peroxidase), is the main oxidoreductase in the use of glutathione as a reducing agent in scavenging lipid peroxidation products.
Yangchun Xie +3 more
semanticscholar +1 more source
Autophagy-monitoring and autophagy-deficient mice [PDF]
Autophagy, 2017 Discovery of yeast autophagy-related (ATG) genes and subsequent identification of their homologs in other organisms have enabled researchers to investigate physiological functions of macroautophagy/autophagy using genetic techniques. Specific identification of autophagy-related structures is important to evaluate autophagic activity, and specific ...
Akiko Kuma +2 more
openaire +2 more sources
Tracking autophagy during proliferation and differentiation of trypanosoma brucei [PDF]
, 2014 Autophagy is a lysosome-dependent degradation mechanism that sequesters target cargo into autophagosomal vesicles. The Trypanosoma brucei genome contains apparent orthologues of several autophagy-related proteins including an ATG8 family. These ubiquitin-
Coombs, Graham H. +3 more
core +3 more sources
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
Journal of Cell Biology, 2008 Loss-of-function mutations in Park2, the gene coding for the ubiquitin ligase Parkin, are a significant cause of early onset Parkinson's disease.
Derek P. Narendra +3 more
semanticscholar +1 more source
Frontiers in Endocrinology, 2019 Chronic consumption of high fat diets (HFDs), rich in saturated fatty acids (SatFAs) like palmitic acid (PA), is associated with the development of obesity and obesity-related metabolic diseases such as type II diabetes mellitus (T2DM).
María Paz Hernández-Cáceres +28 more
doaj +1 more source
Pharmacological activation of SIRT6 triggers lethal autophagy in human cancer cells [PDF]
, 2018 Sirtuin 6 (SIRT6) is a member of the NAD+-dependent class III deacetylase sirtuin family, which plays a key role in cancer by controlling transcription, genome stability, telomere integrity, DNA repair, and autophagy.
Annamaria Biroccio, And +13 more
core +2 more sources