Results 41 to 50 of about 449,405 (356)
Structure and Dynamics in the ATG8 Family From Experimental to Computational Techniques
Frontiers in Cell and Developmental Biology, 2020 Autophagy is a conserved and essential intracellular mechanism for the removal of damaged components. Since autophagy deregulation is linked to different kinds of pathologies, it is fundamental to gain knowledge on the fine molecular and structural ...
Valentina Sora +6 more
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Autophagy, 2011 Autophagy is the degradative process by which eukaryotic cells digest their own components using acid hydrolases within the lysosome. Originally thought to function almost exclusively in providing starving cells with nutrients taken from their own cellular constituents, autophagy is in fact involved in numerous cellular events including differentiation,
Duszenko, M. +17 more
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Cell Host & Microbe, 2009 Recent discoveries have revealed the importance of the vitamin D-dependent generation of antimicrobial peptides in human host defense against Mycobacterium tuberculosis. Now, Yuk et al. (2009) show how vitamin D induces autophagy and mediates colocalization of Mycobacterium tuberculosis and antimicrobial peptides within an autophagolysosome, leading to
Mario Fabri, Robert L. Modlin
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Plasma membrane integrity in health and disease: significance and therapeutic potential
Cell Discovery, 2021 Maintenance of plasma membrane integrity is essential for normal cell viability and function. Thus, robust membrane repair mechanisms have evolved to counteract the eminent threat of a torn plasma membrane.
Catarina Dias, Jesper Nylandsted
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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
Journal of Cell Biology, 2008 Loss-of-function mutations in Park2, the gene coding for the ubiquitin ligase Parkin, are a significant cause of early onset Parkinson's disease.
Derek P. Narendra +3 more
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Autophagy in neutrophils [PDF]
The Korean Journal of Physiology & Pharmacology, 2020 Autophagy is a highly conserved intracellular degradation and energy-recycling mechanism that contributes to the maintenance of cellular homeostasis. Extensive researches over the past decades have defined the role of autophagy innate immune cells. In this review, we describe the current state of knowledge regarding the role of autophagy in neutrophil ...
Chang-Won Hong +2 more
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The Role of Autophagy in Pancreatic Cancer—Recent Advances
Biology, 2019 Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers with a 5-year survival rate of only 9%, despite ongoing efforts to improve treatment.
Maria New, Sharon Tooze
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Cell Death Discovery, 2022 Acute kidney injury (AKI) is a common clinical condition associated with high morbidity and mortality. The pathogenesis of AKI has not been fully elucidated, with a lack of effective treatment. Renal tubular epithelial cells (TECs) play an important role
Zixian Li +9 more
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Autophagy, selective autophagy, and necroptosis in COPD
International Journal of Chronic Obstructive Pulmonary Disease, 2018 COPD is characterized by persistent respiratory symptoms and airflow limitation, caused by a mixture of small airway disease and pulmonary emphysema. Programmed cell death has drawn the attention of COPD researchers because emphysema is thought to result from epithelial cell death caused by smoking.
Kenji Mizumura +3 more
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Autophagy-monitoring and autophagy-deficient mice [PDF]
Autophagy, 2017 Discovery of yeast autophagy-related (ATG) genes and subsequent identification of their homologs in other organisms have enabled researchers to investigate physiological functions of macroautophagy/autophagy using genetic techniques. Specific identification of autophagy-related structures is important to evaluate autophagic activity, and specific ...
Akiko Kuma +2 more
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