Results 51 to 60 of about 449,405 (356)
Nature Communications, 2019 Autophagy adaptors and receptors contain LC3-interacting region (LIR) motifs that bind selectively to the LIR docking site of GABARAP and other members of the ATG8 family. Here the authors show that in addition to the LIR motif also the region C-terminal
Martina Wirth +8 more
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Reviews in Medical Virology, 2009 AbstractAutophagy is an evolutionarily conserved intracellular process by which bulk cytoplasm is enveloped inside a double‐membraned vesicle and shuttled to lysosomes for degradation. Within the last 15 years, the genes necessary for the execution of autophagy have been identified and the number of tools for studying this process has grown.
Beth Levine, Sagar B. Kudchodkar
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Autophagy and tumorigenesis [PDF]
FEBS Letters, 2009 Autophagy, or cellular self‐digestion, is activated in cancer cells in response to multiple stresses and has been demonstrated to promote tumor cell survival and drug resistance. Nonetheless, genetic evidence supports that autophagy functions as a tumor suppressor mechanism.
Nan Chen, Jayanta Debnath
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How autophagy controls the intestinal epithelial barrier
Autophagy, 2021 Macroautophagy/autophagy is a cellular catabolic process that results in lysosome-mediated recycling of organelles and protein aggregates, as well as the destruction of intracellular pathogens.
E. Foerster +5 more
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Autophagy and metabolism [PDF]
The Kaohsiung Journal of Medical Sciences, 2020 AbstractMetabolism consists of diverse life‐sustaining chemical reactions in living organisms. Autophagy is a highly conservative process that responds to various internal and external stresses. Both processes utilize surrounding resources to provide energy and nutrients for the cell.
Man Ling Chu +3 more
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Emerging roles of TFE3 in metabolic regulation
Cell Death Discovery, 2023 TFE3 is a member of the MiT family of the bHLH-leucine zipper transcription factor. We previously focused on the role of TFE3 in autophagy and cancer. Recently, an increasing number of studies have revealed that TFE3 plays an important role in metabolic ...
Xingyu Li +6 more
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Autophagy: process and function.
Genes & Development, 2007 Autophagy is an intracellular degradation system that delivers cytoplasmic constituents to the lysosome. Despite its simplicity, recent progress has demonstrated that autophagy plays a wide variety of physiological and pathophysiological roles, which are
N. Mizushima
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Atg8ylation as a general membrane stress and remodeling response
Cell Stress, 2021 The yeast Atg8 protein and its paralogs in mammals, mammalian Atg8s (mAtg8s), have been primarily appreciated for their participation in autophagy. However, lipidated mAtg8s, including the most frequently used autophagosomal membrane marker LC3B, are ...
Suresh Kumar, Jingyue Jia1, Vojo Deretic
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Reactive Oxygen Species-Induced Lipid Peroxidation in Apoptosis, Autophagy, and Ferroptosis
Oxidative Medicine and Cellular Longevity, 2019 Reactive oxygen species- (ROS-) induced lipid peroxidation plays a critical role in cell death including apoptosis, autophagy, and ferroptosis. This fundamental and conserved mechanism is based on an excess of ROS which attacks biomembranes, propagates ...
L. Su +7 more
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JMA Journal, 2021 Autophagy is a major intracellular degradation system and plays important roles in various physiological processes such as metabolic adaptation and intracellular homeostasis. It degrades intracellular components both randomly and selectively. Autophagic activity is tightly regulated primarily by nutrient availability, but also by other extracellular ...
Yasuhiro Yamamoto, Noboru Mizushima
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