Results 51 to 60 of about 687,627 (397)
HUNK Phosphorylates Rubicon to Support Autophagy [PDF]
, 2019 Background: Autophagy is a catabolic cellular recycling pathway that is essential for maintaining intracellular homeostasis. Autophagosome formation is achieved via the coordination of the Beclin-1 protein complex.
Abt, Melissa +5 more
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Nature Communications, 2019 Autophagy adaptors and receptors contain LC3-interacting region (LIR) motifs that bind selectively to the LIR docking site of GABARAP and other members of the ATG8 family. Here the authors show that in addition to the LIR motif also the region C-terminal
Martina Wirth +8 more
doaj +1 more source
Plasma membrane integrity in health and disease: significance and therapeutic potential
Cell Discovery, 2021 Maintenance of plasma membrane integrity is essential for normal cell viability and function. Thus, robust membrane repair mechanisms have evolved to counteract the eminent threat of a torn plasma membrane.
Catarina Dias, Jesper Nylandsted
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Glutamate induces autophagy via the two-pore channels in neural cells [PDF]
, 2016 NAADP (nicotinic acid adenine dinucleotide phosphate) has been proposed as a second messenger for glutamate in neuronal and glial cells via the activation of the lysosomal Ca2+ channels TPC1 and TPC2.
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Microscopy Research and Technique, 2004 AbstractGlycogen autophagy, which includes the sequestration and degradation of cell glycogen in the autophagic vacuoles, is a selective process under conditions of demand for the massive hepatic production of glucose, as in the postnatal period. It represents a link between autophagy and glycogen metabolism. The formation of autophagic vacuoles in the
Kotoulas, O. B. +2 more
openaire +3 more sources
Autophagy in DNA Damage Response [PDF]
, 2015 DNA damage response (DDR) involves DNA repair, cell cycle regulation and apoptosis, but autophagy is also suggested to play a role in DDR. Autophagy can be activated in response to DNA-damaging agents, but the exact mechanism underlying this activation ...
Elzbieta Pawlowska +4 more
core +5 more sources
FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates [PDF]
, 2019 The autophagy cargo receptor p62 facilitates the condensation of misfolded, ubiquitin-positive proteins and their degradation by autophagy, but the molecular mechanism of p62 signaling to the core autophagy machinery is unclear.
Abert, Christine +9 more
core +1 more source
Emerging roles of TFE3 in metabolic regulation
Cell Death Discovery, 2023 TFE3 is a member of the MiT family of the bHLH-leucine zipper transcription factor. We previously focused on the role of TFE3 in autophagy and cancer. Recently, an increasing number of studies have revealed that TFE3 plays an important role in metabolic ...
Xingyu Li +6 more
doaj +1 more source
Autophagy, 2013 These days, when we talk about the origin of a protein, or even a pathway, we are typically referring to evolutionary lineages based on nucleotide sequences. For example, is a particular protein's function conserved? How far back did it first appear? Are there homologs in higher eukaryotes?
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Spatially and temporally defined lysosomal leakage facilitates mitotic chromosome segregation
Nature Communications, 2020 Lysosomes are intracellular organelles containing degradative enzymes, and leakage of lysosomal contents into the cell is thought to trigger cell death.
Saara Hämälistö +11 more
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