Results 111 to 120 of about 116,566 (305)

Autophagy-related lncRNAs in tumor progression and drug resistance: A double-edged sword

Genes and Diseases
The incidence and mortality rates of cancer are increasing every year worldwide but the survival rate of cancer patients is still unsatisfactory. Therefore, it is necessary to further elucidate the molecular mechanisms involved in tumor development and ...
Yunchao Zhang, Jiayu Tang, Cheng Wang, Qinxiu Zhang, Anqi Zeng, Linjiang Song   +5 more
doaj   +1 more source

Autophagy Biomarkers in Hypersensitivity Pneumonitis [PDF]

C58. ACUTE LUNG INJURY: ATYPICAL TRIGGERS, 2020
S. Cabrera, C. Rodriguez-Bobadilla, M. Gaxiola, D. Vazquez-Morales, M. Selman, A. Pardo   +5 more
openaire   +1 more source

ELABELA Targets Mitochondria to Modulate Heart Development

Advanced Science, EarlyView.
The role of peptide ELABELA (ELA) in cardiomyocyte apoptosis and congenital heart disease (CHD) is unclear. ELA deficiency caused cardiomyocyte apoptosis and CHD. A novel ELA‐APJ‐AKT‐BCL2/BAX axis in regulating mitochondrial function and contributing to CHD pathogenesis was established.
Jian Wang, Qingjie Wang, Zhikang Xu, Shuang Zhou, Yue Zhou, Junjie Yang, Lingfeng Tong, Zhuo Meng, Mei Yang, Wen Zhao, Tie Yang, Hualin Wang, Jun Zhang, Rubin Tan, Lei Wang, Yuqiang Huang, Bin Zhou, Sun Chen, Bing Zhang, Jinxiang Yuan, Jianyuan Zhao, Alex F. Chen, Kun Sun   +22 more
wiley   +1 more source

Effects of spermidine supplementation on cognition and biomarkers in older adults with subjective cognitive decline (SmartAge)—study protocol for a randomized controlled trial [PDF]

, 2019
Background: Given the global increase in the aging population and age-related diseases, the promotion of healthy aging is one of the most crucial public health issues.
Benson, Gloria, Buchert, Ralph, Flöel, Agnes, Grittner, Ulrike, Hetzer, Stefan, Horn, Nora, Kopp, Ute, Köbe, Theresa, Lange, Catharina, Madeo, Frank, Maglione, Marta, Mai, Knut, Michael, Eva, Märschenz, Stefanie, Schmitz, Dietmar, Schwarz, Claudia, Sigrist, Stephan J., Stekovic, Slaven, Wirth, Miranka   +18 more
core   +2 more sources

Can Enhanced Autophagy Be Associated with Human Longevity? Serum Levels of the Autophagy Biomarker Beclin-1 Are Increased in Healthy Centenarians

Rejuvenation Research, 2014
Autophagy is a major clearance mechanism that degrades organelles and large protein aggregates to maintain cell survival and protein homeostasis. Although induction of autophagy can promote longevity in experimental models, the question as to whether increased basal levels of autophagy can be associated with human longevity remains
Emanuele, Enzo, Minoretti, Piercarlo, Sanchís-Gomar, Fabián, Pareja Galeano, Helios, Yilmaz, Yusuf, Garatachea, Nuria, Lucía Mulas, Alejandro   +6 more
openaire   +4 more sources

Farnesyltransferase Deficiency in Cardiomyocytes Initiates Senescence and Contributes to Cardiac Fibrosis

Advanced Science, EarlyView.
Lipid overload suppresses SREBF2‐mediated FNTB expression, leading to defective Lamin A maturation and nuclear envelope instability. This nuclear catastrophe triggers a pro‐fibrotic senescence program in cardiomyocytes. Notably, restoring nuclear integrity via AAV9‐based gene therapy effectively attenuates cardiac remodeling, identifying the ...
Yuxiao Chen, Lian Lou, Xuan Zhang, Lin Yan, Qi Zhang, Wen Shi, Jie Ding, Xu Lin, Rong Jiang, Shuo Liu, Thida Sok, Pengli Wang, Yun Mou, Jie Han, Shenjiang Hu, Xiaogang Guo, Jian Yang   +16 more
wiley   +1 more source

Epigenetic Down-Regulation of Sirt 1 via DNA Methylation and Oxidative Stress Signaling Contributes to the Gestational Diabetes Mellitus-Induced Fetal Programming of Heart Ischemia-Sensitive Phenotype in Late Life. [PDF]

, 2019
Rationale: The incidence of gestational diabetes mellitus (GDM) is increasing worldwide. However, whether and how GDM exposure induces fetal programming of adult cardiac dysfunctional phenotype, especially the underlying epigenetic molecular mechanisms ...
Chen, Zewen, Gong, Lei, Li, Yong, Liu, Bailin, Xiao, Daliao, Zhang, Lubo, Zhang, Peng, Zhuang, Jian   +7 more
core  

Mode of action of Cr(VI) in immunocytes of earthworms: Implications for animal health [PDF]

, 2017
Chromium (Cr) is one of the major and most detrimental pollutant, widely present in the environment as a result of several anthropogenic activities. In mammalian cells, Cr(VI) is known to enhance reactive oxygen species (ROS) production and to cause ...
Banni, M, Boeri, M, Moore, MN, Mou, Z, Sforzini, S, Viarengo, A   +5 more
core   +1 more source

Identifying autophagy gene-associated module biomarkers through construction and analysis of an autophagy-mediated ceRNA‑ceRNA interaction network in colorectal cancer

International Journal of Oncology, 2018
Autophagy is crucial in cellular homeostasis and has been implicated in the development of malignant tumors. However, the regulatory function of autophagy in cancer remains to be fully elucidated. In the present study, the autophagy-mediated competing endogenous RNA (ceRNA)‑ceRNA interaction networks in colorectal cancer (CRC) were constructed by ...
Qian, Kun, Huang, Huiying, Jiang, Jing, Xu, Dahua, Guo, Shengnan, Cui, Ying, Wang, Hao, Wang, Liqiang, Li, Kongning   +8 more
openaire   +3 more sources

Targeting the PGRN‐BMP Lysosomal Axis With NPs@PGRN Reverses Immunometabolic Dysfunction in Chronic Septic Arthritis

Advanced Science, EarlyView.
Chronic septic arthritis involves intracellular bacterial persistence and lipid‐immune crosstalk via the PGRN‐BMP lysosomal axis. A dual‐targeting nanoparticle system (NPs@PGRN) restores lysosomal bactericidal function, reduces bacterial burden, and reprograms macrophage immunity, offering a novel therapeutic strategy. ABSTRACT Chronic septic arthritis,
Congsun Li, Jiaqi Fan, Tao Sun, Wushi Cui, Jiaxuan Zou, Weinan Yang, Liang Chen, Jian Xiao, Shicheng Wang, Tao Zhang, Jianqiao Hong, An Liu, Haobo Wu   +12 more
wiley   +1 more source