Results 91 to 100 of about 116,566 (305)

Implication of LAMP proteins and autophagy markers in colorectal cancer aggressiveness

Frontiers in Immunology
Lysosome-associated membrane proteins (LAMPs) play a critical role in various cellular processes, including phagocytosis, lipid transport, neoangiogenesis, and tissue remodeling.
Tsvetomira Ivanova, Tsvetomira Ivanova, Dorian Dikov, Diana Molander, Angel M. Dzhambov, Yordan Sbirkov, Yordan Sbirkov, Nikolay Mehterov, Nikolay Mehterov, Nikolay Belev, Boyko Atanasov, Boyko Atanasov, Maria Kazakova, Maria Kazakova, Victoria Sarafian, Victoria Sarafian   +15 more
doaj   +1 more source

Influence of Crohn’s disease related polymorphisms in innate immune function on ileal microbiome [PDF]

, 2019
We have previously identified NOD2 genotype and inflammatory bowel diseases (IBD) phenotype, as associated with shifts in the ileal microbiome (“dysbiosis”) in a patient cohort.
Ciorba, Matthew A, Davidson, Nicholas O, Frank, Daniel N, Gathungu, Grace, Li, Ellen, Nelson, Leah M, Robertson, Charles E, Sartor, R. Balfour, Shiekh, Shehzad S, Tian, Xinyu, Wang, Xuefeng, Wolber, Ashley, Zhang, Yuanhao, Zhu, Wei   +13 more
core   +3 more sources

Identification of Autophagy-Related Biomarkers in Ischemic Stroke

Journal of Contemporary Medical Practice
Objective: This study utilizes bioinformatics technology to screen and predict potential diagnostic autophagy related biomarkers in CIS. Methods: By analyzing genes in the GEO dataset GSE16561 and the autophagy database HADb, differentially expressed genes (DEGs) related to autophagy in CIS were identified.
Yaoyao Dai, Rui HaoGeng Wang, Mengqi Shu, Chen Zhang   +3 more
openaire   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Research progress on the association of autophagy with invasion and metastasis of malignant melanoma

Pifu-xingbing zhenliaoxue zazhi
Autophagy is a unique biological phenomenon of eukaryotic cells. Autophagy plays a very important role in promoting the survival of cells and actively adapting to different environments. Autophagy plays a double-edged role in the development of tumor and
Xiang GAO, Xuening ZHAO, Zhao HAN
doaj   +1 more source

Identification of Autophagy-Related Biomarkers and Diagnostic Model in Alzheimer’s Disease

Genes
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease. Its accurate pathogenic mechanisms are incompletely clarified, and effective therapeutic treatments are still inadequate. Autophagy is closely associated with AD and plays multiple roles in eliminating harmful aggregated proteins and maintaining cell homeostasis.
Wei Xu, Xi Su, Jing Qin, Ye Jin, Ning Zhang, Shasha Huang   +5 more
openaire   +2 more sources

FRI0397 Peculiar expression of autophagy biomarkers in necrotizing autoimmune myopathy muscle [PDF]

Annals of the Rheumatic Diseases, 2018
Background Immune mediated necrotizing myopathy (IMNM) is a recently recognised pathology within the spectrum of idiopathic inflammatory myopathies (IIMs). Specific autoantibodies and the response to immunosuppressants aid to make the diagnosis and suggest immune-mediated pathogenesis, although histopathological features are not specific for IMNM ...
M. Giannini, F. Girolamo, A. Amati, A. Lia, L. Serlenga, D. D'Abbicco, M. Tampoia, F. Iannone   +7 more
openaire   +1 more source

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source

LncRNA LUCAT1 offers protection against human coronary artery endothelial cellular oxidative stress injury through modulating hsa-miR-6776-5p/LRRC25 axis and activating autophagy flux

Journal of Translational Medicine
Background Coronary artery disease (CAD) has become a dominant economic and health burden worldwide, and the role of autophagy in CAD requires further clarification.
Yanjun Wang, Xin Zhang, Mengmeng Ren, Shu He, Hengjie Bie, Mengyang Duan, Zhiyuan Chen, Qiaowei Jia, Boyu Chi, Xiongkang Gan, Chengcheng Li, Yahong Fu, Hanxiao Zhou, Sheng Zhang, Qian Zhang, Fenghui An, Xiumei Chen, Enzhi Jia   +17 more
doaj   +1 more source

Evidence that hematopoietic stem cell function is preserved during aging in long-lived S6K1 mutant mice [PDF]

, 2016
The mechanistic target of rapamycin (mTOR) signalling pathway plays a highly conserved role in aging; mice lacking ribosomal protein S6 kinase 1 (S6K1-/-) have extended lifespan and healthspan relative to wild type (WT) controls. Exactly how reduced mTOR
Irvine, Elaine E., Michie, Alison M., Pedroni, Silvia M.A., Selman, Colin, Sinclair, Amy, Withers, Dominic J.   +5 more
core   +2 more sources