Results 131 to 140 of about 80,599 (213)

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

Mitophagy and Noncoding RNA Regulation in Type 2 Diabetes Mellitus: Molecular Mechanisms, Tissue-Specific Evidence and Translational Perspective. [PDF]

Biomedicines
Kothari A, Narayanan MP, Yadav SRM, Kumari R, Kumar H, Kherdekar R, Yadav S, Shaw P, Chakrapani B, Ansari P, Kumar A, Shrinkhal, Patel DK, Seidel V, Pandey A, Misra A, Kumar S.   +16 more
europepmc   +1 more source

Trehalose's untapped mechanisms in alzheimer's: gut-brain-autophagy signalling beyond the usual targets. [PDF]

Daru
Gunasekaran SK, K HKC, Gobinath M, Roychowdhury P, N MS.   +4 more
europepmc   +1 more source

The translational potential of m6A RNA methylation in DKD: emerging biomarkers for early detection and targeted therapies. [PDF]

Front Med (Lausanne)
Liu H, Luo J, Dai Y, Wu C, An Y, Jiang W.   +5 more
europepmc   +1 more source

Identification and mechanistic investigation of novel biomarkers for diabetic retinopathy through hypoxia- and cuproptosis-associated gene analysis. [PDF]

PLoS One
Feng R, Wang X, Li X, Zhao Z, Long B, Zhang H, Yue F.   +6 more
europepmc   +1 more source

Cardiovascular Diseases and Cancer: Convergent Proteostasis Networks at the Crossroads of Mechanisms and Therapeutic Opportunities. [PDF]

MedComm (2020)
García Torres JE, Frey N, Rangrez AY.
europepmc   +1 more source

Transcriptomic Profiling in Skeletal Muscle Identifies Associations With Knee Osteoarthritis: the Study of Muscle, Mobility and Aging (SOMMA)

Arthritis &Rheumatology, Accepted Article.
Objectives The association between skeletal muscle gene expression and knee osteoarthritis (OA) was examined among older adult participants of the Study of Muscle, Mobility and Aging (SOMMA). Methods Inclusion criteria included knee radiographs and bulk RNA sequencing (RNAseq) in vastus lateralis muscle, resulting in 523 participants (56% female ...
Daniel S. Evans, Tyler A. Mansfield, Gina M. Many, Tyler J. Sagendorf, Samaneh Farsijani, Bret H. Goodpaster, Lauren M. Sparks, Nancy E. Lane   +7 more
wiley   +1 more source

CASP1 as a key autophagy-related gene in atherosclerosis: Identification by bioinformatics analysis and experimental validation. [PDF]

PLoS One
Gao H, Guo Y, Wang L, Shen Y, Liu W.
europepmc   +1 more source

Possible therapeutic repositioning of valproic acid: From epileptic seizures to acute kidney injury

British Journal of Clinical Pharmacology, EarlyView.
Valproic acid, an anticonvulsant, may be repositioned to prevent acute kidney injury due to ischemia followed by reperfusion. It preserves renal functions, electrolyte homeostasis and active sodium transport in kidney tubules, and blocks the onset of hypertension.
Danilo Alves‐Bezerra, Luiza B. Negreiros, Amaury Pereira‐Acácio, Isadora G. Almeida, João P. M. Veloso‐Santos, Jarlene A. Lopes, Glória Costa‐Sarmento, Humberto Muzi‐Filho, Adalberto Vieyra   +8 more
wiley   +1 more source

Research Progress on Pathogenesis of Diabetic Nephropathy and Intervention with Traditional Chinese Medicine. [PDF]

J Multidiscip Healthc
Guan Y, Huang J, Ma J, Qiu L, Wu X, Dong Y, Luo W, Lei Z.   +7 more
europepmc   +1 more source