Results 141 to 150 of about 116,566 (305)

Gemella morbillorum Promotes Colorectal Carcinogenesis: LPBDCP‐Mediated Invasion Activates Ras Signaling and Destabilizes p53

Advanced Science, EarlyView.
ABSTRACT Gut microbiota dysbiosis promotes colorectal cancer (CRC) tumorigenesis. A global fecal metagenomic analysis identified Gemella morbillorum as a key contributor to the CRC‐associated microbiota. Fluorescence in situ hybridization revealed that Gemella morbillorum is enriched in CRC tumor tissues compared to adjacent normal tissues.
Zhen Wang, Jia Zhang, Haojie Lu, Jingjing Ni, Shuaishuai Yang, Yuting Shi, Shuo Zhang, Pei Zhang, Li Liu   +8 more
wiley   +1 more source

Intracellular Aβ42 Sequestration by a Serine Protease Mitigates Neurotoxicity in a Drosophila Alzheimer's Disease Model

Advanced Science, EarlyView.
Emerging evidence suggests that intraneuronal Aβ accumulation represents an early pathogenic event in Alzheimer's disease (AD). Using Drosophila AD model, this study shows that a nonsecreted serine protease Yip7 physically interacts with Aβ. This causes intraneuronal Aβ accumulation but surprisingly reduces the associated neurotoxicity, arguing that ...
Jingyun Su, Meng Yang, Xinfeng Wang, Pa Wu, Zongzhao Zhai   +4 more
wiley   +1 more source

Non-invasive biomarkers for brain aging: the role of autophagy-related microRNAs in plasma exosomes

Frontiers in Molecular Neuroscience
AimThis study aimed to identify autophagy-related microRNAs (miRNAs) in plasma exosomes as non-invasive biomarkers for brain aging and explore their potential to improve early detection of age-associated neurodegeneration.
Qian Cheng, Shuyi Yu, Zhikang Cui, Hang Chen, Jing Fan, Qian Yu, Yan Jin, Yunshan Wang, Ming Li, Zhiming Lu   +9 more
doaj   +1 more source

O‐GlcNAcylated TAP1 Impairs Antigen Presentation and Promotes Immune Evasion in Bladder Cancer

Advanced Science, EarlyView.
This article unveils a critical mechanism of immune evasion in bladder cancer, which the O‐GlcNAc modification of TAP1 disrupts antigen presentation. This modification triggers HLA‐A degradation, shielding tumor cells from CD8+ T cell attack. The findings highlight targeting this pathway as a promising therapeutic avenue to sensitize tumors to ...
Jinpeng Wu, Xueting Ren, Zhen Zhai, Lu Wang, Liang Liang, Zengqi Tan, Jiazhen Zhao, Yuxuan Han, Yuhan Li, Feng Guan, Xiang Li   +10 more
wiley   +1 more source

PROTEOLYSIS AND AUTOPHAGY IN THE VASTUS LATERALIS OF PATIENTS WITH BRONCHIECTASIS-ASSOCIATED SARCOPENIA: ROLE IN TRAINING PROGRAMS

Open Respiratory Archives
Introduction: Muscle dysfunction or sarcopenia is a systemic manifestation of chronic respiratory diseases such as COPD and non-cystic fibrosis (non-CF) bronchiectasis.
Cinta Cumplí Gargallo, Adriana Núñez-Robainas, Mariela Alvarado-Miranda, Marina Sáinz, Esther Barreiro   +4 more
doaj   +1 more source

HSP90AA1 is a biomarker associated with defective autophagy in osteoarhritis [PDF]

Osteoarthritis and Cartilage, 2020
I. Lorenzo-Gómez, U. Nogueira-Recalde, N. Oreiro, J. Pinto-Tasende, F.J. Blanco, B. Carames   +5 more
openaire   +1 more source

NUP85 Mediates Endoplasmic Reticulum Stress through the USP47/ASK1 Signaling Pathway to Regulate the Progression of Liver Fibrosis

Advanced Science, EarlyView.
In the present study, we have demonstrated that the NUP85‐USP47‐ASK1 signaling pathway may have regulated the progression of liver fibrosis through modulating ERS. Additionally, we have developed a CREKA‐coupled liposome to target delivery of MV, a pharmacological inhibitor of NUP85, to activated HSCs, thereby attenuating liver fibrosis. ABSTRACT Liver
Dashuai Yang, Haoran Yang, Linxin Pan, Chang Tian, Fucheng Zuo, Shilei Huang, Xianrui Li, Ming Chen, Cheng Qian, Jie Wang, Zhaolin Chen, Tao Xu   +11 more
wiley   +1 more source

Autophagy-related molecular clusters identified as indicators for distinguishing active and latent TB infection in pediatric patients

BMC Pediatrics
Background Autophagy is crucial for controlling the manifestation of tuberculosis. This study intends to discover autophagy-related molecular clusters as biomarkers for discriminating between latent tuberculosis (LTBI) and active tuberculosis (ATB) in ...
Yang Yu, Jie Hua, Liang Chen
doaj   +1 more source

Multi‐Organelle Stress‐Induced Paraptosis by a ROS‐Amplifying Nanocatalyst for Enhanced Cancer Immunotherapy

Advanced Science, EarlyView.
The engineered TF‐Fe@LC nanoplatform programs paraptotic death via multipath ROS amplification that disrupts redox homeostasis, provoking mitochondrial dysfunction, autophagic blockade, and ER stress. This caspase‐independent process elicits robust immunogenic cell death, combining with αPD‐L1 to activate systemic CD8+ T‐cell immunity and suppress ...
Zhe Yu, Haozhe Ren, Hua Li, Jinghan Zhao, Miaomiao Cao, Tian Tang, Youbei Qiao, Liting Chen, Tiehong Yang, Hong Wu   +9 more
wiley   +1 more source

Resveratrol-based nano-formulations as an emerging therapeutic strategy for ovarian carcinoma: autophagy stimulation and SIRT-1/Beclin/MMP-9/P53/AKT signaling

Cancer Nanotechnology
Background Resveratrol (RVS) is a stilbene derivative polyphenolic compound extensively recognized for its anti-inflammatory, antioxidant and anti-aging properties, along with its enormous promise in carcinoma treatment.
Mai O. Kadry
doaj   +1 more source