Results 31 to 40 of about 133,686 (278)

Pixel Detectors for Particle Detection and Imaging Applications [PDF]

Nucl.Instrum.Meth. A512 (2003) 277-288, 2002
Semiconductor pixel detectors offer features for the detection of radiation which are interesting for particle physics detectors as well as for imaging e.g. in biomedical applications (radiography, autoradiography, protein crystallography) or in Xray astronomy.
arxiv   +1 more source

Penetration, distribution, and elimination of remofuscin/soraprazan in Stargardt mouse eyes following a single intravitreal injection using pharmacokinetics and transmission electron microscopic autoradiography: Implication for the local treatment of Stargardt’s disease and dry age‐related macular degeneration

Pharmacology Research & Perspectives, 2020
Age‐related macular degeneration (AMD) is the leading cause of blindness in older people in the developed world while Stargardt's disease (SD) is a juvenile macular degeneration and an orphan disease.
Sylvie Julien‐Schraermeyer, Barbara Illing, Alexander Tschulakow, Tatjana Taubitz, Jamil Guezguez, Michael Burnet, Ulrich Schraermeyer   +6 more
doaj   +1 more source

[¹²⁵I]INFT: Synthesis and Evaluation of a New Imaging Agent for Tau Protein in Post-Mortem Human Alzheimer’s Disease Brain

Molecules, 2023
Aggregation of Tau protein into paired helical filaments causing neurofibrillary tangles (NFT) is a neuropathological feature in Alzheimer’s disease (AD).
Roz R. Limpengco, Christopher Liang, Yasmin K. Sandhu, Jogeshwar Mukherjee   +3 more
doaj   +1 more source

Trends in Pixel Detectors: Tracking and Imaging [PDF]

IEEE Trans.Nucl.Sci.51:1006-1015,2004, 2004
For large scale applications, hybrid pixel detectors, in which sensor and read-out IC are separate entities, constitute the state of the art in pixel detector technology to date. They have been developed and start to be used as tracking detectors and also imaging devices in radiography, autoradiography, protein crystallography and in X-ray astronomy. A
arxiv   +1 more source

Analysis of capecitabine metabolites in conjunction with digital autoradiography in a murine model of pancreatic cancer suggests extensive drug penetration through the tumor

Pharmacology Research & Perspectives, 2022
Previously published digital autoradiography of 3H‐labeled capecitabine reveals a near‐uniform distribution of activity throughout a murine pancreatic model.
James Russell, Louise Fanchon, Hanan Alwaseem, Henrik Molina, Isabella O’Donoghue, Amber Bahr, Elisa deStanchina, Nagavarakishore Pillarsetty, John L. Humm   +8 more
doaj   +1 more source

Imaging of Gα_q Proteins in Mouse and Human Organs and Tissues

Pharmaceutics, 2022
G protein-coupled receptors (GPCRs) transfer extracellular signals across cell membranes by activating intracellular heterotrimeric G proteins. Several studies suggested G proteins as novel drug targets for the treatment of complex diseases, e.g., asthma
Jan H. Voss, Haneen Al-Hroub, Robin Gedschold, Jennifer M. Dietrich, Evelyn Gaffal, Marieta Toma, Stefan Kehraus, Gabriele M. König, Peter Brust, Bernd K. Fleischmann, Daniela Wenzel, Winnie Deuther-Conrad, Christa E. Müller   +12 more
doaj   +1 more source

In Vitro and In Vivo Characterization of Selected Fluorine-18 Labeled Radioligands for PET Imaging of the Dopamine D3 Receptor

Molecules, 2016
Cerebral dopamine D3 receptors seem to play a key role in the control of drug-seeking behavior. The imaging of their regional density with positron emission tomography (PET) could thus help in the exploration of the molecular basis of drug addiction.
Natascha Nebel, Simone Maschauer, Torsten Kuwert, Carsten Hocke, Olaf Prante   +4 more
doaj   +1 more source

Cholinergic Depletion in Alzheimer's Disease Shown by [18F]FEOBV Autoradiography

International Journal of Molecular Imaging, 2013
Rationale. Alzheimer's Disease (AD) is a neurodegenerative condition characterized in part by deficits in cholinergic basalocortical and septohippocampal pathways.
Maxime J Parent, M. Bedard, Arturo Aliaga, L. Minuzzi, N. Mechawar, J. Soucy, E. Schirrmacher, A. Kostikov, S. Gauthier, P. Rosa-Neto   +9 more
semanticscholar   +1 more source

Differential Sphingosine-1-Phosphate Receptor-1 Protein Expression in the Dorsolateral Prefrontal Cortex Between Schizophrenia Type 1 and Type 2

Frontiers in Psychiatry, 2022
Understanding the etiology and treatment approaches in schizophrenia is challenged in part by the heterogeneity of this disorder. One encouraging progress is the growing evidence that there are subtypes of schizophrenia.
Ganesh B. Chand, Hao Jiang, J. Philip Miller, C. Harker Rhodes, Zhude Tu, Dean Foster Wong, Dean Foster Wong   +6 more
doaj   +1 more source

Reduced Metabotropic Glutamate Receptor Type 5 Availability in the Epileptogenic Hippocampus: An in vitro Study

Frontiers in Neurology, 2022
Abnormalities in the expression of metabotropic glutamate receptor type 5 (mGluR5) have been observed in the hippocampus of patients with drug-resistant mesial Temporal Lobe Epilepsy (mTLE).
Maria Zimmermann, Maria Zimmermann, Luciano Minuzzi, Luciano Minuzzi, Arturo Aliaga Aliaga, Arturo Aliaga Aliaga, Marie-Christine Guiot, Jeffery A. Hall, Jean-Paul Soucy, Jean-Paul Soucy, Gassan Massarweh, Salah El Mestikawy, Pedro Rosa-Neto, Pedro Rosa-Neto, Eliane Kobayashi   +14 more
doaj   +1 more source