Results 31 to 40 of about 193,799 (312)

Differential Sphingosine-1-Phosphate Receptor-1 Protein Expression in the Dorsolateral Prefrontal Cortex Between Schizophrenia Type 1 and Type 2

Frontiers in Psychiatry, 2022
Understanding the etiology and treatment approaches in schizophrenia is challenged in part by the heterogeneity of this disorder. One encouraging progress is the growing evidence that there are subtypes of schizophrenia.
Ganesh B. Chand, Hao Jiang, J. Philip Miller, C. Harker Rhodes, Zhude Tu, Dean Foster Wong, Dean Foster Wong   +6 more
doaj   +1 more source

Translocator protein in late stage Alzheimer\u27s disease and Dementia with Lewy bodies brains [PDF]

, 2019
OBJECTIVE: Increased translocator protein (TSPO), previously known as the peripheral benzodiazepine receptor (PBR), in glial cells of the brain has been used as a neuroinflammation marker in the early and middle stages of neurodegenerative diseases, such
Bales, Kelly R, Benzinger, Tammie L S, Holtzman, David M, Mach, Robert H, Morris, John C, Perrin, Richard J, Sun, Jianjun, Xu, Jinbin   +7 more
core   +2 more sources

Receptor localization of steroid hormones and drugs: discoveries through the use of thaw-mount and dry-mount autoradiography

Brazilian Journal of Medical and Biological Research, 1998
The history of receptor autoradiography, its development and applications, testify to the utility of this histochemical technique for localizing radiolabeled hormones and drugs at cellular and subcellular sites of action in intact tissues.
W.E. Stumpf
doaj   +1 more source

Criteria of applicability for autoradiography of tritium [PDF]

, 1993
Autoradiography is an effective tool for the imaging of radionuclide distributions in various samples. In sophisticated applications with special preparation and development of sample-emulsion combinations and subsequent grain counts it can be highly ...
Chen, J., Kellerer, Albrecht M., Roos, H.   +2 more
core   +1 more source

Association fibre pathways of the brain: parallel observations from diffusion spectrum imaging and autoradiography.

Brain : a journal of neurology, 2007
Understanding the long association pathways that convey cortical connections is a critical step in exploring the anatomic substrates of cognition in health and disease.
J. Schmahmann, D. Pandya, Ruopeng Wang, G. Dai, H. D'Arceuil, A. de Crespigny, V. Wedeen   +6 more
semanticscholar   +1 more source

Mechanistic Insights into the Stimulant Properties of Novel Psychoactive Substances (NPS) and Their Discrimination by the Dopamine Transporter—In Silico and In Vitro Exploration of Dissociative Diarylethylamines

Brain Sciences, 2018
Novel psychoactive substances (NPS) may have unsuspected addiction potential through possessing stimulant properties. Stimulants normally act at the dopamine transporter (DAT) and thus increase dopamine (DA) availability in the brain, including nucleus ...
Michelle A. Sahai, Colin Davidson, Neelakshi Dutta, Jolanta Opacka-Juffry   +3 more
doaj   +1 more source

Penetration, distribution, and elimination of remofuscin/soraprazan in Stargardt mouse eyes following a single intravitreal injection using pharmacokinetics and transmission electron microscopic autoradiography: Implication for the local treatment of Stargardt’s disease and dry age‐related macular degeneration

Pharmacology Research & Perspectives, 2020
Age‐related macular degeneration (AMD) is the leading cause of blindness in older people in the developed world while Stargardt's disease (SD) is a juvenile macular degeneration and an orphan disease.
Sylvie Julien‐Schraermeyer, Barbara Illing, Alexander Tschulakow, Tatjana Taubitz, Jamil Guezguez, Michael Burnet, Ulrich Schraermeyer   +6 more
doaj   +1 more source

Mapping and Functional Role of Phosphorylation Sites in the Thyroid Transcription Factor-1 (TTF-1) [PDF]

, 1996
The phosphorylation of thyroid transcription factor-1 (TTF-1), a homeodomain-containing transcription factor that is required for thyroid-specific expression of the thyroglobulin and thyroperoxidase gene promoters, has been studied.
Acebron, Alvaro, Arnone, Maria Ina, De Felice, Mario, Di Lauro, Roberto, Martin-Pérez, Jorge, Santisteban, Pilar, Zannini, Mariastella   +6 more
core   +1 more source

Reduced Metabotropic Glutamate Receptor Type 5 Availability in the Epileptogenic Hippocampus: An in vitro Study

Frontiers in Neurology, 2022
Abnormalities in the expression of metabotropic glutamate receptor type 5 (mGluR5) have been observed in the hippocampus of patients with drug-resistant mesial Temporal Lobe Epilepsy (mTLE).
Maria Zimmermann, Maria Zimmermann, Luciano Minuzzi, Luciano Minuzzi, Arturo Aliaga Aliaga, Arturo Aliaga Aliaga, Marie-Christine Guiot, Jeffery A. Hall, Jean-Paul Soucy, Jean-Paul Soucy, Gassan Massarweh, Salah El Mestikawy, Pedro Rosa-Neto, Pedro Rosa-Neto, Eliane Kobayashi   +14 more
doaj   +1 more source

Hyperglycaemia does not increase perfusion deficits after focal cerebral ischaemia in male Wistar rats [PDF]

, 2018
Background: Hyperglycaemia is associated with a worse outcome in acute ischaemic stroke patients; yet the pathophysiological mechanisms of hyperglycaemia-induced damage are poorly understood.
Dewar, Deborah, Holmes, William M., MacDonald, Kathleen, Macrae, I. Mhairi, Muir, Keith W., Thow, Lisa A.   +5 more
core   +1 more source