Results 41 to 50 of about 133,686 (278)

Synthesis and Evaluation of 125I Labeled Chalcone Derivatives Containing Bithiophene Moiety as Potential Aβ Probes

Journal of Isotopes, 2015
In continuation of the investigation on the bithiophene structure as potential Aβ probes, two halogenated chalcone derivatives containing bithiophene moiety were designed and evaluated as imaging probes for Aβ plaques.
PENG Cheng, CUI Meng-chao, LIANG Zhi-gang, LIU Ting-ting   +3 more
doaj   +1 more source

Amyloid-Targeting PET Tracer [18F]Flutemetamol Accumulates in Atherosclerotic Plaques

Molecules, 2019
Atherosclerosis is characterized by the accumulation of oxidized lipids in the artery wall, which triggers an inflammatory response. Oxidized low-density lipoprotein (ox-LDL) presents amyloid-like structural properties, and different amyloid species have
Sanna Hellberg, Johanna M.U. Silvola, Heidi Liljenbäck, Max Kiugel, Olli Eskola, Harri Hakovirta, Sohvi Hörkkö, Veronique Morisson-Iveson, Ella Hirani, Pekka Saukko, Seppo Ylä-Herttuala, Juhani Knuuti, Antti Saraste, Anne Roivainen   +13 more
doaj   +1 more source

64Cu-ATSM and 18FDG PET uptake and 64Cu-ATSM autoradiography in spontaneous canine tumors: comparison with pimonidazole hypoxia immunohistochemistry

Radiation Oncology, 2012
BackgroundThe aim of this study was to compare 64Cu-diacetyl-bis(N4-methylsemicarbazone) (64Cu-ATSM) and 18FDG PET uptake characteristics and 64Cu-ATSM autoradiography to pimonidazole immunohistochemistry in spontaneous canine sarcomas and carcinomas ...
A. E. Hansen, A. Kristensen, J. Jørgensen, F. McEvoy, M. Busk, A. J. van der Kogel, J. Bussink, S. Engelholm, A. Kjær   +8 more
semanticscholar   +1 more source

Asymmetric Synthesis of Spirocyclic 2-Benzopyrans for Positron Emission Tomography of σ1 Receptors in the Brain

Pharmaceuticals, 2014
Sharpless asymmetric dihydroxylation of styrene derivative 6 afforded chiral triols (R)-7 and (S)-7, which were cyclized with tosyl chloride in the presence of Bu2SnO to provide 2-benzopyrans (R)-4 and (S)-4 with high regioselectivity.
Katharina Holl, Dirk Schepmann, Steffen Fischer, Friedrich-Alexander Ludwig, Achim Hiller, Cornelius K. Donat, Winnie Deuther-Conrad, Peter Brust, Bernhard Wünsch   +8 more
doaj   +1 more source

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

Proceedings of the National Academy of Sciences of the United States of America, 1979
A method has been devised for the electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets. The method results in quantitative transfer of ribosomal proteins from gels containing urea.
H. Towbin, T. Staehelin, J. Gordon
semanticscholar   +1 more source

TRPC4 ion channel protein is selectively expressed in a subpopulation of dopamine neurons in the ventral tegmental area [PDF]

, 2012
The nonselective cation channel TRPC4 has been shown to be present in high abundance in the corticolimbic regions of the brain and play a pivotal role in modulating cellular excitability due to their involvement in intracellular Ca2+ regulation. Recently we reported their involvement in socialization and regulating anxiety-like behaviors in rats. Given
arxiv   +1 more source

Synthesis and Evaluation of Compound Targeting α7 and β2 Subunits in Nicotinic Acetylcholinergic Receptor

Molecules, 2023
Nicotinic acetylcholine receptors (nAChRs) are involved in various central nervous system functions and have also been implicated in several neurodegenerative disorders.
Karanveer Singh, Allyson Ngo, Oshini V. Keerthisinghe, Krystal K. Patel, Christopher Liang, Jogeshwar Mukherjee   +5 more
doaj   +1 more source

α-Synuclein Overexpression Increases Dopamine D2/3 Receptor Binding and Immune Activation in a Model of Early Parkinson’s Disease

Biomedicines, 2021
Progressive degeneration of dopaminergic neurons, immune activation, and α-synuclein pathology characterize Parkinson’s disease (PD). We previously reported that unilateral intranigral injection of recombinant adeno-associated viral (rAAV) vectors ...
Kathrine Stokholm, Majken Borup Thomsen, Jenny-Ann Phan, Line K. Møller, Cecilie Bay-Richter, Søren H. Christiansen, David P. D. Woldbye, Marina Romero-Ramos, Anne M. Landau   +8 more
doaj   +1 more source

Early reduced dopaminergic tone mediated by D3 receptor and dopamine transporter in absence epileptogenesis [PDF]

Epilepsia, 2019, 60 (10), pp.2128-2140
Abstract Objective In Genetic Absence Epilepsy Rats From Strasbourg ( GAERS s), epileptogenesis takes place during brain maturation and correlates with increased mRNA expression of D3 dopamine receptors (D3R). Whether these alterations are the consequence of seizure repetition or contribute to the development of epilepsy remains to be clarified.
arxiv   +1 more source

Characterizing the binding of TC-5619 and encenicline on the alpha7 nicotinic acetylcholine receptor using PET imaging in the pig

Frontiers in Neuroimaging
The alpha7 nicotinic acetylcholine receptor (α7-nAChR) has has long been considered a promising therapeutic target for addressing cognitive impairments associated with a spectrum of neurological and psychiatric disorders, including Alzheimer's disease ...
Janus H. Magnussen, Janus H. Magnussen, Anders Ettrup, Szabolcs Lehel, Dan Peters, Agnete Dyssegaard, Morten S. Thomsen, Morten S. Thomsen, Jens D. Mikkelsen, Jens D. Mikkelsen, Gitte M. Knudsen, Gitte M. Knudsen   +11 more
doaj   +1 more source