Results 81 to 90 of about 193,799 (312)

A novel 18F-labelled high affinity agent for PET imaging of the translocator protein [PDF]

, 2015
The translocator protein (TSPO) is an important target for imaging focal neuroinflammation in diseases such as brain cancer, stroke and neurodegeneration, but current tracers for non-invasive imaging of TSPO have important limitations.
Adele Blair, Adriana A. S. Tavares, Andrew Sutherland, Anthony J. Chalmers, Deborah Dewar, Filip Zmuda, Gaurav Malviya, Gilles D. Tamagnan, Sally L. Pimlott   +8 more
core   +1 more source

Improved detection of molecular markers of atherosclerotic plaques using sub-millimeter PET imaging [PDF]

, 2020
Since atherosclerotic plaques are small and sparse, their non-invasive detection via PET imaging requires both highly specific radiotracers as well as imaging systems with high sensitivity and resolution.
Bormans, Guy, Bridoux, Jessica, Broisat, Alexis, Caveliers, Vicky, Cleeren, Frederik, Debie, Pieterjan, Descamps, Benedicte, Devoogdt, Nick, Hernot, Sophie, Neyt, Sara, Vanhove, Christian, Xavier, Catarina   +11 more
core   +2 more sources

Human FASTK preferentially binds single‐stranded and G‐rich RNA

The FEBS Journal, EarlyView.
Although FASTK is known to play a role in mRNA biology, the mechanism through which it recognizes RNA has yet to be unraveled. Here, we used purified human FASTK to characterize its RNA‐binding properties in vitro. We found that FASTK prefers ssRNA oligonucleotides containing guanines with the potential to form G‐quadruplexes and binds robustly to any ...
Daria M. Dawidziak, Dawid A. Dzadz, Mikołaj I. Kuska, Madhuri Kanavalli, Maria M. Klimecka, Matthew Merski, Katarzyna J. Bandyra, Maria W. Górna   +7 more
wiley   +1 more source

Modification of dopamine neurotransmission in the nucleus accumbens of rats deficient in n–3 polyunsaturated fatty acids

Journal of Lipid Research, 2000
We studied the effects of a diet chronically deficient in α-linolenic acid, the precursor of long-chain n–3 polyunsaturated fatty acids, on dopaminergic neurotransmission in the shell region of the nucleus accumbens of rats.
Luc Zimmer, Sylvie Delion-Vancassel, Georges Durand, Denis Guilloteau, Sylvie Bodard, Jean-Claude Besnard, Sylvie Chalon   +6 more
doaj  

The bZIP3‐AS1 complex promotes CONSTANS‐induced FLOWERING LOCUS T activation in a daylength‐dependent manner

Journal of Integrative Plant Biology, EarlyView.
The Arabidopsis bZIP3 protein works in conjunction with ASYMMETRIC LEAVES1 to facilitate the function of the CONSTANS protein in activating FLOWERING LOCUS T expression at the end of the day in a day length‐dependent manner. ABSTRACT Plants monitor daylength to synchronize their flowering time with their surroundings and thus maximize reproductive ...
Wonbok Lee, Sun Ho Kim, Junsang Park, So Hee Yoon, Sung Won Cho, Nayoung Lee, Shogo Ito, Takato Imaizumi, Jong Chan Hong, Woo Sik Chung, Young Hun Song   +10 more
wiley   +1 more source

In vitro autoradiography of receptor-activated G proteins in rat brain by agonist-stimulated guanylyl 5'-[gamma-[35S]thio]-triphosphate binding.

Proceedings of the National Academy of Sciences of the United States of America, 1995
Agonists stimulate guanylyl 5'-[gamma-[35S]thio]-triphosphate (GTP[gamma-35S]) binding to receptor-coupled guanine nucleotide binding protein (G proteins) in cell membranes as revealed in the presence of excess GDP.
L. J. Sim, D. Selley, S. Childers
semanticscholar   +1 more source

Measurement of Aβ Amyloid Plaques and Tau Protein in Postmortem Human Alzheimer’s Disease Brain by Autoradiography Using [¹⁸F]Flotaza, [¹²⁵I]IBETA, [^124/125I]IPPI and Immunohistochemistry Analysis Using QuPath

Biomedicines, 2023
High-resolution scans of immunohistochemical (IHC) stains of Alzheimer’s disease (AD) brain slices and radioligand autoradiography both provide information about the distribution of Aβ plaques and Tau, the two common proteinopathies in AD.
Rommani Mondal, Yasmin K. Sandhu, Vallabhi M. Kamalia, Brooke A. Delaney, Amina U. Syed, Grace A. H. Nguyen, Taylor R. Moran, Roz R. Limpengco, Christopher Liang, Jogeshwar Mukherjee   +9 more
doaj   +1 more source

Functional expression of the polymeric immunoglobulin receptor from cloned cDNA in fibroblasts. [PDF]

, 1986
The polymeric immunoglobulin receptor, a transmembrane protein, is made by a variety of polarized epithelial cells. After synthesis, the receptor is sent to the basolateral surface where it binds polymeric IgA and IgM.
Deitcher, DL, Mostov, KE, Neutra, MR
core  

Biosynthesis of Mitochondrial Porin and Insertion into the Outer Mitochondrial Membrane of Neuruspora crassa [PDF]

, 1982
Mitochondrial porin, the major protein of the outer mitochondrial membrane is synthesized by free cytoplasmic polysomes. The apparent molecular weight of the porin synthesized in homologous or heterologous cell-free systems is the same as that of the ...
Cassady W. E., Colombini M., Conboy J. G., Cote C., Cowlesmith I., Freitag H., Glizin V., Hallermayer R., Hennig B., Korb H., Lewin A., Maccecchini M. L., Maccechini M. L., Matsuura S., Mihara K., Nabi N., Nelson N., Neupert W., Oda T., Palmiter R. D., Payvar F., Raymond Y., Scheele G., Schleyer M., Schmelzer E., Sebald W., Sherton C. C., Shore G. C., Sonderegger P., Teintze M., Ullrich A., Zelman L. S., Zimmermann R., Zimmermann R., Zimmermann R., Zimmermann R.   +35 more
core   +1 more source

Overexpression of the short isoform of the dopamine D2 receptor causes diet‐induced obesity and hyperglycemia in mice

Journal of Neuroendocrinology, EarlyView.
Alterations in the expression levels of D2S and D2L resulted in obesity and metabolic syndrome such as abdominal fat accumulation and hyperglycemia in D2L KO mice fed with a high‐fat diet, compared to WT mice. This may be partly due to increased food intake.
Hanna Gonzalez, Lei Cheng, Qing Chang, Paul E. Gold, Diego Perez‐Tilve, YanYan Wang   +5 more
wiley   +1 more source