Results 71 to 80 of about 6,031 (179)

Mass spectrometric characterisation of avenanthramides and enhancing their production by germination of oat (Avena sativa)

, 2019
Avenanthramides are amides, with a phenylalkenoic acid (PA) and an anthranilic acid (AA) subunit, which are secondary metabolites of oat. Oat seeds were germinated, extracted, and the avenanthramides analysed by a combination of UHPLC with ion trap and ...
Dinteren, Sarah, van, Vincken, Jean Paul, Gruppen, Harry, Bruijn, Wouter J.C., de   +3 more
core   +1 more source

Up-regulation of NADPH oxidase-mediated redox signaling contributes to the loss of barrier function in KRIT1 deficient endothelium

Scientific Reports, 2017
The intracellular scaffold KRIT1/CCM1 is an established regulator of vascular barrier function. Loss of KRIT1 leads to decreased microvessel barrier function and to the development of the vascular disorder Cerebral Cavernous Malformation (CCM).
Luca Goitre, Peter V. DiStefano, Andrea Moglia, Nicholas Nobiletti, Eva Baldini, Lorenza Trabalzini, Julie Keubel, Eliana Trapani, Vladimir V. Shuvaev, Vladimir R. Muzykantov, Ingrid H. Sarelius, Saverio Francesco Retta, Angela J. Glading   +12 more
doaj   +1 more source

Unveiling the complexity of cellular senescence in cancers: From mechanism to therapeutic opportunities

BMEMat, Volume 3, Issue 3, September 2025.
This review highlights the complex roles of cellular senescence in cancer progression and suppression, discusses the mechanisms and regulatory pathways involved, and evaluates the efficacy of the “One‐Two punch” sequential treatment approach while addressing emerging challenges in this novel therapeutic strategy.
Qiuming Pan, Ye Zhu, Zhi Ye, Huayang Zhang, Junxi Wang, Guozhong Yi, Zhiyong Li, Rongyang Xu, Luyao Wang, Zhenzhen Wu, Songtao Qi, Guanglong Huang, Shanqiang Qu   +12 more
wiley   +1 more source

A Combination of Moringin and Avenanthramide 2f Inhibits the Proliferation of Hep3B Liver Cancer Cells Inducing Intrinsic and Extrinsic Apoptosis

, 2018
Moringin (MOR), a glycosyl-isothiocyanate obtained by myrosinase-catalyzed hydrolysis of the precursor 4-(α-l-rhamnosyloxy)-benzyl glucosinolate (glucomoringin), found predominantly in the seeds of Moringa oleifera, shows anticancer effects against ...
Iori, Renato, Ninfali, Paolino, Antonini, Elena, Scarpa, Emanuele Salvatore   +3 more
core   +1 more source

Oat Bran Supplementation Improves Glucose Metabolism, Food Addiction, and Gut Microbiota in Rats With High‐Fat Diet‐Induced Obesity

Food Frontiers, Volume 6, Issue 5, Page 2204-2230, September 2025.
ABSTRACT Oat bran (OB), a byproduct of the oat milling process, is a nutrient‐dense cereal cultivated in cool, dry mountainous regions and is known for its potential health benefits. To explore its obesity‐alleviating effects and the underlying mechanisms, we examined the influence of OB on glucose metabolism, appetite‐regulating hormones, gut ...
Xue Bai, Meili Zhang, Yakun Zhang, Yuanyuan Zhang, Rui Huo, Qixin Gu, Ying Miao   +6 more
wiley   +1 more source

Variations in tocopherol, tocotrienol, avenanthramide and saponin content in oats and the influence of milling and baking processes [PDF]

Oats, as whole-grain cereal, are a good source of nutrients, including compounds located in the outer layers of groats, such as fibre and bioactive compounds.
Pihlava, Juha-Matti, Piironen, Vieno, Hietaniemi, Veli, Pöysä, Marjo, Fedotov, Anna, Lampi, Anna-Maija   +5 more
core   +1 more source

Avenanthramide-C reduces the viability of MDA-MB-231 breast cancer cells through an apoptotic mechanism

Cancer Cell International, 2017
Background Avenanthramides (AVN) are a relatively unstudied family of phytochemicals that could be novel chemotherapeutics. These compounds, found in oats, are non-toxic to healthy cells and have been shown to reduce viability of human colon and liver ...
Jordan Hastings, Jason Kenealey
doaj   +1 more source

Phenolic amides (avenanthramides) in oats – an update review

Bioengineered
Oats (Avena sativa L.) are one of the worldwide cereal crops. Avenanthramides (AVNs), the unique plant alkaloids of secondary metabolites found in oats, are nutritionally important for humans and animals. Numerous bioactivities of AVNs have been investigated and demonstrated in vivo and in vitro.
Xie, Xi, Lin, Miaoyan, Xiao, Gengsheng, Liu, Huifan, Wang, Feng, Liu, Dongjie, Ma, Lukai, Wang, Qin, Li, Zhiyong   +8 more
openaire   +2 more sources

Cellular Senescence in Cancer: Mechanisms, Roles in Tumor Progression, and Therapeutic Implications

MedComm – Oncology, Volume 4, Issue 3, September 2025.
Senescent tumor cells in TME exhibit dual roles. “Angels” secrete SASPs/DAMPs to boost immunological clearance and antitumor immunity via MHC‐I upregulation; “Demons” produce tumor‐promoting SASPs recruiting MDSCs to drive malignancy. ABSTRACT Cellular senescence, a state of irreversible cell cycle arrest accompanied by a senescence‐associated ...
Jingrui Yan, Yu Zhang, Guohua Mao, Jun Yu, Tianxing Zhou, Jihui Hao   +5 more
wiley   +1 more source

Analysis of the Involvement of Hydroxyanthranilate Hydroxycinnamoyltransferase and Caffeoyl-CoA 3-O-Methyltransferase in Phytoalexin Biosynthesis in Oat

Molecular Plant-Microbe Interactions, 2004
Two oat genes encoding hydroxycinnamoyl-CoA:hydroxyanthranilate N-hydroxycinnamoyltransferase (HHT) and S-adenosyl-l-methionine:trans-caffeoyl-CoA 3-O-methyltransferase (CCoAOMT), both of which are possibly involved in the biosynthesis of oat ...
Qian Yang, Hoat Xuan Trinh, Satoshi Imai, Atsushi Ishihara, Liqun Zhang, Hitoshi Nakayashiki, Yukio Tosa, Shigeyuki Mayama   +7 more
doaj   +1 more source