Results 61 to 70 of about 14,987 (195)

AP‐1‐Targeting Decoy Oligonucleotides: Mechanisms and Therapeutic Potential as Modulators of Inflammatory Pathways

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Numerous cellular functions, such as apoptosis, proliferation, differentiation, survival, transformation and cell migration, are regulated by a crucial transcription factor called activator protein 1 (AP‐1). Growing evidence indicates that AP‐1 is involved in severe conditions like fibrosis, cancer, and organ damage, as well as inflammatory ...
Maryam Mahjoubin‐Tehran, Samaneh Rezaei, Vasily N. Sukhorukov, Amin Jalili, Prashant Kesharwani, Amirhossein Sahebkar   +5 more
wiley   +1 more source

Prospects for transgenesis in the chick [PDF]

, 2004
Research to develop a useful method for genetic modification of the chick has been on-going since the first demonstrations in the mouse in the 1980s that genetic modification is an invaluable tool for the study of gene function. Manipulation of the chick
Bosselman, Brazolot, Carsience, Challita, D'Costa, Evans, Eyal-Giladi, Hamburger, Han, Harvey, Harvey, Hofmann, Ikawa, Isvak, Itasaki, Ivarie, Kagami, Lois, Love, Mizuarai, Mozdziak, Mozdziak, Naito, Naito, Naito, Naldini, Nieuwkoop, Niwa, Pain, Perry, Petitte, Petitte, Pfeifer, Rapp, Reynaud, Rubinson, Salter, Salter, Sang, Sherman, Speksnijder, Stern, Tajima, Thomson, Thoraval, Tiscornia, Tsunekawa, Urven, Vick, Vick, Waddington, Wentworth, Zajchowski   +52 more
core   +1 more source

Integrative Approaches to Treating Cellular Senescence in Kidney Disease

Advanced Science, Volume 13, Issue 21, 13 April 2026.
ABSTRACT Cellular senescence in the kidney plays a crucial role in the progression of acute kidney injury and chronic kidney disease. Therapeutic approaches targeting senescent cells, such as small molecule senolytic and senomorphic drugs, display efficacy in preclinical models.
Tomoka Misawa, Amruta A, LaTonya J. Hickson, Joy Wolfram   +3 more
wiley   +1 more source

A Very Strong Enhancer Is Located Upstream of an Immediate Early Gene of Human Cytomegalovirus [PDF]

, 1985
A strong transcription enhancer was identified in the genomic DNA (235 kb) of human cytomegalovirus (HCMV), a ubiquitous and severe pathogen of the herpesvirus group.
Boshart, Michael, Dorsch-Häsler, Karoline, Fleckenstein, Bernhard, Jahn, Gerhard, Schaffner, Walter, Weber, Frank   +5 more
core   +1 more source

Infection Risk From Humans and Animals in the Anatomy Laboratory: A Scoping Review

Clinical Anatomy, Volume 39, Issue 3, Page 346-367, April 2026.
ABSTRACT Whole‐body dissection is a cornerstone of anatomy education. During and following the COVID‐19 pandemic, exposure to infectious agents and other risks of dissection were highlighted. To identify potential risks, one must have the data outlining these risks in specific situations.
Margaret A. McNulty, Elizabeth R. Agosto
wiley   +1 more source

A study on the isolation of leukemia virus of AKR mouse by fluorocarbon [PDF]

, 1962
The authors have succeeded in isolating a biologically-active leukemia virus from leukemic tissues of AKR mice with a fluorocarbon. From the chemical analysis of the biologically-active virus fraction it has been clarified that the AKR leukemia virus is ...
Miyoshi, Isao, Okada, Koichi
core   +1 more source

Engineering multiple levels of specificity in an RNA viral vector [PDF]

, 2020
Synthetic molecular circuits could provide powerful therapeutic capabilities, but delivering them to specific cell types and controlling them remains challenging.
Chong, Lucy S., Elowitz, Michael B., Gao, Xiaojing J., Ince, Michaela H., Kim, Matthew S.   +4 more
core   +1 more source

Influenza virus infection drives upregulation of CD84 across a broad range of immune cells

Clinical &Translational Immunology, Volume 15, Issue 3, 2026.
Our findings reveal a link between high CD84 expression in humans and recovery from respiratory viral infections. In influenza virus‐infected mice, CD84 is upregulated on a broad range of innate and adaptive immune cell populations, particularly on activated and influenza virus‐specific T‐cell populations and associated with less disease severity ...
Xiaoxiao Jia, Isabelle JH Foo, Hayley A McQuilten, Jeremy Chase Crawford, Aira F Cabug, Deborah Gebregzabher, Janet Chou, Robert C Mettelman, Tanya Novak, Lee‐Ann Van de Velde, Ryan S Thwaites, Adrienne G Randolph, Paul G Thomas, Jianqing Xu, Zhongfang Wang, Katherine Kedzierska, Lukasz Kedzierski, Brendon Y Chua   +17 more
wiley   +1 more source

Role of PQBP1 in Pathogen Recognition—Impact on Innate Immunity

Viruses
The intrinsically disordered polyglutamine-binding protein 1 (PQBP1) has been linked to various cellular processes including transcription, alternative splicing, translation and innate immunity.
Lukas Wiench, Domenico Rizzo, Zora Sinay, Zsófia Nacsa, Nina V. Fuchs, Renate König   +5 more
doaj   +1 more source

Plasma proteomic profiling and molecular clustering reveal immune‐defined prognostic subtypes in lung adenocarcinoma

International Journal of Cancer, Volume 158, Issue 4, Page 858-865, 15 February 2026.
What's new? Lung adenocarcinoma shows considerable heterogeneity in disease progression and therapeutic response. Here, the authors analyzed tumor samples through proteomic profiling and applied network‐based clustering. They identified two distinct patient groups with different demographic, clinical, and molecular characteristics.
Ujjwal Neogi, Anoop T. Ambikan, Kati Turkowski, Marc A. Schneider, Vanessa M. Beutgen, Johannes Graumann, Hauke Winter, Marek Bartkuhn, Werner Seeger, Soni S. Pullamsetti, Rajkumar Savai   +10 more
wiley   +1 more source