Results 31 to 40 of about 13,248 (184)

Successful Rapid Desensitization to Ceftazidime/Avibactam in a Patient With Cystic Fibrosis and Multidrug-Resistant <i>Pseudomonas aeruginosa</i> Pneumonia: A Case Report. [PDF]

Clin Case Rep
ABSTRACT Ceftazidime/avibactam (CAZ‐AVI) is an important therapeutic option for multidrug‐resistant (MDR) Pseudomonas aeruginosa infections; however, hypersensitivity reactions may preclude its use and create significant therapeutic challenges. We report a 21‐year‐old woman with cystic fibrosis and recurrent MDR P.
Zhou Z, Zhu J, Wu G, Kang X, Wang Q, Liu J, Jiang Y.   +6 more
europepmc   +2 more sources

Μηχανισμοί αντοχής στον αναστολέα καρβαπενεμασών avibactam [PDF]

, 2023
H Avibactam είναι ένας νέος αναστολέας β-λακταμάσης που χρησιμοποιείται συχνά σε συνδυασμό με την Ceftazidime για τη θεραπεία λοιμώξεων που προκαλούνται από πολυανθεκτικά βακτήρια.
Δημητρίου Μαρία, Dimitriou Maria   +1 more
core   +1 more source

Recent Developments to Cope the Antibacterial Resistance via β-Lactamase Inhibition

Molecules, 2022
Antibacterial resistance towards the β-lactam (BL) drugs is now ubiquitous, and there is a major global health concern associated with the emergence of new β-lactamases (BLAs) as the primary cause of resistance.
Zafar Iqbal, Jian Sun, Haikang Yang, Jingwen Ji, Lili He, Lijuan Zhai, Jinbo Ji, Pengjuan Zhou, Dong Tang, Yangxiu Mu, Lin Wang, Zhixiang Yang   +11 more
doaj   +1 more source

The Klebsiella pneumoniae carbapenemase (KPC) β-Lactamase Has Evolved in Response to Ceftazidime Avibactam

Antibiotics, 2023
Klebsiella pneumoniae carbapenemase KPC is an important resistance gene that has disseminated globally in response to carbapenem use. It is now being implicated as a resistance determinant in Ceftazidime Avibactam (CAZ-AVI) resistance. Given that CAZ-AVI
Sona Garsevanyan, Miriam Barlow
doaj   +1 more source

All Roads Lead to Rome: Enhancing the Probability of Target Attainment with Different Pharmacokinetic/Pharmacodynamic Modelling Approaches

Antibiotics, 2023
In light of rising antimicrobial resistance and a decreasing number of antibiotics with novel modes of action, it is of utmost importance to accelerate development of novel treatment options.
Kashaf Khalid, Katharina Rox
doaj   +1 more source

Increased gene expression and copy number of mutated bla KPC lead to high-level ceftazidime/avibactam resistance in Klebsiella pneumoniae

BMC Microbiology, 2021
Background Resistance to ceftazidime-avibactam was reported, and it is important to investigate the mechanisms of ceftazidime/avibactam resistance in K. pneumoniae with mutations in bla KPC. Results We report the mutated bla KPC is not the only mechanism
Lingxiao Sun, Haibo Li, Qi Wang, Yingmei Liu, Bin Cao   +4 more
doaj   +1 more source

Antimicrobial Treatment Strategies for Stenotrophomonas maltophilia: A Focus on Novel Therapies

Antibiotics, 2021
Stenotrophomonas maltophilia is an urgent global threat due to its increasing incidence and intrinsic antibiotic resistance. Antibiotic development has focused on carbapenem-resistant Enterobacteriaceae, Pseudomonas, and Acinetobacter, with approved ...
Jean Gibb, Darren W. Wong
doaj   +1 more source

In Vitro Evaluation of Increasing Avibactam Concentrations on Ceftazidime Activity against Ceftazidime/Avibactam-Susceptible and Resistant KPC-Producing Klebsiella pneumoniae Clinical Isolates [PDF]

, 2023
The novel beta-lactam/beta-lactamase inhibitor combinations (beta L-beta LICs) are one of the last-line resources available against multidrug-resistant (MDR) Gram-negative bacteria.
Secci, Benedetta, Milo Gatti, Palombo, Marta, Paolo Gaibani, Gatti, Milo, Bovo, Federica, Marta Palombo, Benedetta Secci, Simone Ambretti, Ambretti, Simone, Gaibani, Paolo, Federica Bovo   +11 more
core   +1 more source

Synergy between Mecillinam and Ceftazidime/Avibactam or Avibactam against Multi-Drug-Resistant Carbapenemase-Producing Escherichia coli and Klebsiella pneumoniae

, 2022
Background: Carbapenemase-producing Klebsiella pneumoniae and Escherichia coli have become a significant global health challenge. This has created an urgent need for new treatment modalities.
Frederik Boetius Hertz, Frank Hansen, Kolpen, Mette, Løbner-Olesen, Anders, Niels Frimodt-Møller, Godefroid Charbon, Frimodt-Møller, Niels, Karoline Knudsen List, Stine Radmer, Kasper Nørskov Kragh, List, Karoline Knudsen, Charbon, Godefroid, Radmer, Stine, Hertz, Frederik Boetius, Kragh, Kasper Nørskov, Hansen, Frank, Mette Kolpen, Anders Løbner-Olesen   +17 more
core   +1 more source

A Selective Medium for Screening Ceftazidime/Avibactam Resistance in Carbapenem-Resistant Enterobacterales

Frontiers in Microbiology, 2022
Ceftazidime/avibactam (CZA) is an alternative antibiotic used for the treatment of infections caused by carbapenem-resistant Enterobacterales (CRE). However, the CZA-resistant CRE strains have been detected worldwide.
Weiliang Zeng, Wenli Liao, Wenli Liao, Yajie Zhao, Lingbo Wang, Hongyun Shu, Huaiyu Jia, Tao Chen, Ying Zhang, Tieli Zhou, Qing Wu   +10 more
doaj   +1 more source