Results 151 to 160 of about 90,586 (267)

Timing‐Dependent Clearance of p16‐Positive Cells Mitigates Radiation‐Induced Accelerated Aging

Aging Cell, Volume 25, Issue 9, September 2026.
Genotoxic stress induces a progressive accelerated aging‐like phenotype driven by the delayed accumulation of p16Ink4a‐positive senescent cells. Selective clearance of these cells improves healthspan, tissue function, and survival only when initiated after senescent cells have accumulated, highlighting a critical therapeutic window for senescence ...
Karla Valdivieso, Melanie Weigand, Daniela G. Costa, Gung Lee, Nick Pirius, Helene Martini, Shivangi Oberai, Christina Inman, Yi Zhu, Thomas von Zglinicki, Sundeep Khosla, Nathan LeBrasseur, João F. Passos, Tamara Tchkonia, James L. Kirkland, Diana Jurk   +15 more
wiley   +1 more source

Engineering Poly(Lactic-co-Glycolic Acid) (PLGA)-Based Microspheres for Controlled Corticosteroid Delivery in Intra-Articular Cartilage. [PDF]

Pharmaceutics
Samonte PRV, Comolli NK.
europepmc   +1 more source

Periodontitis and Mechanical Forces Modulate Ghrelin Receptor in Periodontal Tissues

APMIS, Volume 134, Issue 9, September 2026.
ABSTRACT Ghrelin signaling, mediated by the growth hormone secretagogue receptor (GHS‐R1a), has emerged as an important regulator of inflammation and bone metabolism. This study investigated GHS‐R1a regulation in periodontal tissues exposed to experimental periodontitis (EP), orthodontic tooth movement (OTM), or both. Human periodontal fibroblasts were
Andressa Vilas Boas Nogueira, Thamiris Cirelli, Maria Eduarda Scordamaia Lopes, Luan Viana Faria, Camila Chierici Marcantonio, Rafael Scaf de Molon, Isis Jordão Pinheiro Ribaldo, Marjan Nokhbehsaim, Sigrun Eick, James Deschner, Joni Augusto Cirelli   +10 more
wiley   +1 more source

Convergent Synthesis of a Bifunctional GPI as a Universal Platform to Access Diverse GPI and GPI-Anchored Protein Probes. [PDF]

Org Lett
Yan X, Rohokale R, Guo Z.
europepmc   +1 more source

The DNA/RNA autophagy protein SIDT2 as a novel neuropathological hallmark in Huntington disease

Brain Pathology, Volume 36, Issue 5, September 2026.
SIDT2‐immunoreactive inclusions are observed in the striatum, cerebral cortex, and hypothalamus in HD cases with different Vonsattel grades, and the frequency of SIDT2‐immunoreactive inclusions is associated with longer CAG repeats in the huntingtin gene.
Sanaz Gabery, Sofia Bergh, Chrisovalantou Huridou, Rachel Y. Cheong, Barbara Baldo, Paul Günther Scheunemann, Marie‐Louisa Schoebel, Linda Holmquist Mengelbier, Elisabet Englund, Catriona McLean, Carsten Saft, Deniz Kirik, Maria Björkqvist, Glenda Halliday, Elisabeth Petrasch‐Parwez, Huu Phuc Nguyen, Jonasz Jeremiasz Weber, Åsa Petersén   +17 more
wiley   +1 more source

Mast cell-specific receptor MrgprB2 selectively mediates oxaliplatin-induced neuropathic pain. [PDF]

J Transl Med
Guan LC, Luo Z, Kothari R, Liu M, Wan J, Uniyal A, Guan AY, Lin Q, Dong X, Liu J.   +9 more
europepmc   +1 more source

Pharmacological activation of NO‐cGMP signalling attenuates metabolic dysfunction‐associated steatohepatitis

British Journal of Pharmacology, Volume 183, Issue 18, Page 5476-5495, September 2026.
Background and Purpose Metabolic dysfunction‐associated steatohepatitis (MASH) is linked to activation of hepatic stellate cells (HSCs) to α‐smooth muscle actin–positive myofibroblasts that produce collagen and proinflammatory cytokines. Quiescent HSCs express the NO‐cGMP signalling axis.
Krithika Rajeeth, Malte Roessing, Moritz Lehners, Lisa Dietz, Anja Schmitt, Stephan Hailfinger, Andreas Peter, Leticia Quintanilla‐Martinez, Irene Gonzalez‐Menendez, Ingmar Mederacke, German Ott, Peter Sandner, Matthias Schwab, Robert Feil, Susanne Feil   +14 more
wiley   +1 more source

Spatiotemporal Confinements of Distance-Dependent Emitters for Enhancing Plasmonic Signals. [PDF]

ACS Appl Mater Interfaces
Aslan Y, Derin E, Sagdic K, Tabaru TE, Karatutlu A, Ortaç B, Inci F.   +6 more
europepmc   +1 more source

Periestropause enhances hypoxia‐induced panic and microglial remodelling without altering respiratory control

Journal of Neuroendocrinology, Volume 38, Issue 9, September 2026.
Abstract Perimenopause is characterised by irregular reproductive cycles and hormonal fluctuations, notably decreased estradiol (E2), which are linked to increased susceptibility to panic disorder and neuroinflammation. We examined whether panic‐related respiratory and behavioural responses to respiratory challenges vary across reproductive stages ...
Angela Cristina Nicola, Luana Tenório‐Lopes, Luis Gustavo A. Patrone, Mariana Bernardes‐Ribeiro, Heloisa H. Vilela‐Costa, Daniele Gandra, Ana Clara Campideli‐Santana, Raphael E. Szawka, Kênia C. Bícego, Rita Cássia M. Dornelles, Luciane H. Gargaglioni   +10 more
wiley   +1 more source

Protein-based nanocarrier delivering kartogenin derivative to cartilage matrix for intra-articular treatment of osteoarthritis. [PDF]

J Drug Deliv Sci Technol
Morici L, Jenni S, Hakim B, Rodríguez-Nogales C, Allémann E, Bajpayee AG, Jordan O.   +6 more
europepmc   +1 more source