Results 131 to 140 of about 130,909 (260)

Endothelial‐to‐mesenchymal transition in the fetoplacental macrovasculature and microvasculature in pregnancies complicated by gestational diabetes

The Journal of Physiology, EarlyView.
Abstract figure legend Transforming growth factor (TGF)‐β2 and interleukin (IL)‐1β induced morphological and molecular changes consistent with endothelial‐to‐mesenchymal transition (EndMT) in HUVECs isolated from both pregnancies complicated by gestational diabetes (GDM) and non‐GDM pregnancies.
Abigail R. Byford, Georgia Fakonti, Ziyu Shao, Sharanam Soni, Sophie L. Earle, Muath Bajarwan, Lara C. Morley, Beth Holder, Eleanor M. Scott, Karen Forbes   +9 more
wiley   +1 more source

Dual-topology insertion of a dual-topology membrane protein. [PDF]

, 2015
Some membrane transporters are dual-topology dimers in which the subunits have inverted transmembrane topology. How a cell manages to generate equal populations of two opposite topologies from the same polypeptide chain remains unclear.
Bowie, James U, Woodall, Nicholas B, Yin, Ying   +2 more
core  

The endocrine product of renal (preglomerular) contractile pericytes depends on prolyl‐4‐hydroxylases 2 and 3

The Journal of Physiology, EarlyView.
Abstract figure legend Preglomerular pericyte‐like SMMHC+ vascular smooth muscle cells (VSMCs) display marked endocrine plasticity. Hypotension caused by salt depletion and angiotensin‐converting enzyme (ACE) inhibition induces a reversible transformation of these VSMCs toward an endocrine state that produces renin.
Bettina K. M. Firmke, Lena M. Süß, Anna‐Lena Forst, Armin Kurtz, Katharina A.‐E. Broeker   +4 more
wiley   +1 more source

Postbiotic Supernatants From Psychobiotic Strains Modulate Antioxidant and Serotonergic Responses

eFood, Volume 7, Issue 3, June 2026.
Cell‐free postbiotic supernatants obtained from psychobiotic strains exhibit strain‐dependent antioxidant and serotonergic effects. SCFA‐rich metabolites enhance antioxidant protection and modulate serotonin release in enterochromaffin cells, supporting their potential as functional ingredients for gut and brain health.
Cocean Ana‐Maria, Zorita Diaconeasa, Calina Ciont, Razvan Odocheanu, Alexandra Machitescu, Floricuta Ranga, Dan Cristian Vodnar   +6 more
wiley   +1 more source

Hyperaldosteronism in Mice Lacking the Distal Polybasic Tract of the γ‐Subunit of the Epithelial Sodium Channel During Sodium Restriction

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Aims The epithelial sodium channel ENaC consists of the subunits α, β, and γ and is activated at an individual channel level by proteolytic processing. Murine γENaC contains a distal polybasic tract 186RKRK mediating proteolytic ENaC activation by serine proteases in vitro.
Daniel Essigke, M. Zaher Kalo, Matthias Wörn, Xia‐Qing Li, Bernhard N. Bohnert, Anja Schork, Andreas L. Birkenfeld, Thomas Ott, Ferruh Artunc   +8 more
wiley   +1 more source

Enhanced PIEZO1 expression in mast cells of mastocytosis skin lesions: Relevance to Darier's sign

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Yoshiaki Kobayashi, Nobuhiro Nakano, Nguyen Quoc Vuong Tran, Yuki Nakamura, Lisa Minai, Takashi Okamoto, Daiki Nakagomi, Tatsuki R. Kataoka, Tatsuyoshi Kawamura, Atsuhito Nakao   +9 more
wiley   +1 more source

TEAD1 Enhances Exosome Secretion and Promotes Exosome‐Mediated Tissue Regeneration

Advanced Science, Volume 13, Issue 25, 4 May 2026.
TEAD1 functions as a crucial molecular switch regulating exosome secretion in various cell types. TEAD1 enhances exosome secretion by upregulating key proteins associated with exosome secretion, including RAB11, CD9, and SNAP23. This study reveals a novel role for TEAD1 in regulating exosome secretion and tissue regeneration, particularly in diabetic ...
Yan Pu, Yi Wan, Wenhao Shi, Bin Li, Haiyue Zhang, Jun Wu, Lingling Li, Wenjia Guo, Chen Ding, Wenjun Yang   +9 more
wiley   +1 more source

Tumor‐Immune‐On‐Chip to Evaluate Pathophysiological Feature of T Lymphocytes Expanded from Patient Tumors and Lymph Node Tissues

Cancer Medicine, Volume 15, Issue 5, May 2026.
3D Tumor‐Immune On‐Chip reveals patient‐derived tumor‐infiltrating lymphocytes (TILs) exhibit superior infiltration and cytotoxicity against colorectal cancer spheroids compared to lymph node T cells, providing a platform to study patient‐specific tumor‐immune interactions for developing personalized cancer immunotherapies.
Gyu‐Bon Cho, Hyun‐Joo Lee, You Jeong Heo, Jihoon Ko, Won‐Suk Lee, Sujin Hyung   +5 more
wiley   +1 more source

Immortalization of Human Adult Alveolar Epithelial Cells to Study Environmental Exposures of the Distal Lung

Current Protocols, Volume 6, Issue 5, May 2026.
Abstract Alveolar epithelial cell type 1 (AT1) and type 2 (AT2) cells make up the saccular gas exchange units of the lung, called alveoli. Formation of alveoli during lung development accounts for the expansive surface area of the lung, allowing for proper respiration and delivery of oxygen to the body.
Evelyn Tran, Laurence St. Pierre, Diego Velarde, Bianca dal Bó, Juan Ramon Alvarez, Kweku Ofosu‐Asante, Nazarius S. Lamango, Yong Huang, Crystal N. Marconett, Zea Borok, Beiyun Zhou, Ite A. Offringa   +11 more
wiley   +1 more source

Adapted Live SARS‐CoV‐2 Vaccine Elicits Rapid Mucosal Immunity, Protects From Disease, and Reduces Shedding of XBB.1.5

European Journal of Immunology, Volume 56, Issue 5, May 2026.
An attenuated live vaccine (OTS‐300) expressing the XBB.1.5 Spike provided rapid and complete protection against homologous challenge in the hamster model, accompanied by fast systemic and mucosal antibody responses and markedly reduced transmission compared with XBB.1.5 mRNA vaccination.
Jana Kochmann, Tobias Britzke, Nico Joël Halwe, Lorenz Ulrich, Angele Breithaupt, G. Tuba Barut, Nadine Ebert, Bettina Salome Trüeb, Volker Thiel, Anca Dorhoi, Martin Beer, Donata Hoffmann, Björn Corleis, Jacob Schön   +13 more
wiley   +1 more source