Results 121 to 130 of about 90,586 (267)

Oral Delivery of Bioencapsulated CTB‐Pro‐IGF‐1 Enhances Bone Regeneration in a Pre‐Clinical Rat Model of Jaw Osteoradionecrosis

Oral Diseases, EarlyView.
ABSTRACT Objective Head and neck cancer radiotherapy can lead to jaw osteoradionecrosis (ORN). There is currently no definitive treatment for ORN. The efficacy of a novel orally delivered aglycosylated IGF‐1 with an E‐peptide (CTB‐Pro‐IGF‐1), bioencapsulated in plant cells, was evaluated as therapy for jaw ORN in rats. Materials and Methods Rat jaw ORN
Sunday O. Akintoye, Arularasan Anbinselvam, Prasath Jeyaraman, Uddhab Karki, Geetanjali Wakade, Henry Daniell   +5 more
wiley   +1 more source

Raman Spectroscopy Study of the Avidin-Biotin Complex

, 1995
Raman spectra of avidin, biotin and the avidin-biotin complex were recorded. The percentages of secondary structure of avidin and the avidin-biotin complex were obtained from the Raman spectra.
C Fagnano, G Fini, A Torreggiani
core  

Reversible Biofunctionalization of Surfaces with a Switchable Mutant of Avidin

, 2016
Label-free biosensors detect binding of prey molecules (″analytes″) to immobile bait molecules on the sensing surface. Numerous methods are available for immobilization of bait molecules.
Barbara Taskinen (476111), Andreas Ebner (1278063), Vesa P. Hytönen (1337616), Marc Creus (1264563), Hanno Stutz (1897684), Sergey Gusenkov (1897678), Dominik Zauner (1703269), Andreas Scherfler (1897681), Robert Tampé (1311447), Hermann J. Gruber (1278057), Clemens Schwarzinger (301547), Wolfgang Schöfberger (1282569), Philipp Pollheimer (1278051), Philipp Wiesauer (1897687)   +13 more
core   +1 more source

Biomarkers Correlating With the Development of Oral Squamous Cell Carcinoma From Leukoplakia

Oral Diseases, EarlyView.
ABSTRACT Background We assessed protein biomarkers expressed in oral leukoplakia (OL) that are associated with the risk of transformation into oral squamous cell carcinoma (OSCC). Methods Tissue sections of OL transforming into OSCC (leuko‐ca), the corresponding OSCC and OL that did not progress to OSCC (leuko‐nonca) were analyzed with global relative ...
Daniel Giglio, Divya Ganesh, Bishwa Prakash Bhattarai, Tine Merete Søland, Jonas Sundberg, Annika Thorsell, Jenny Öhman, Dipak Sapkota, Bengt Hasséus   +8 more
wiley   +1 more source

Amyloid‐Forming Amylin Secreted by the Pancreas Promotes Hypoxia‐Inducible Factor Activation and Mitochondrial Alterations in Liver and Heart During Type 2 Diabetes Pathogenesis

Comprehensive Physiology, Volume 16, Issue 5, October 2026.
Human amylin is secreted from the pancreas of HIP rats and is amyloidogenic, forming aggregates systemically. In comparison with age‐matched control (WT), hyperglycemic (UCD) and amylin knockout rats (AKO), HIP rats showed increased hypoxia‐inducible factors (HIF‐1/2) in heart and liver, alongside alterations in mitochondrial electron transfer system ...
Alice E. Knapton, Nirmal Verma, Deepak Kotiya, Alice P. Sowton, Benjamin D. Thackray, Lorenz M. W. Holzner, Paula M. Darwin, Sanda Despa, Florin Despa, Andrew J. Murray   +9 more
wiley   +1 more source

β‐Caryophyllene Mitigates Thioacetamide‐Induced Liver Fibrosis Through CB2‐Mediated Suppression of Necroptosis: A Therapeutic Investigation

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
β‐Caryophyllene is a multifunctional sesquiterpene with significant therapeutic potential. Our findings demonstrate that β‐caryophyllene exerts broad hepatoprotective effects through the activation of cannabinoid type 2 (CB2) receptors. These effects include suppression of oxidative stress–induced injury, attenuation of inflammatory responses ...
Lujain Bader Eddin, Seenipandi Arunachalam, Loay Lubbad, Fayez T. Hammad, Ernest Adeghate, Sandeep Subramanya, Shreesh Ojha   +6 more
wiley   +1 more source

Novel Biologically Active Silver-Avidin Hybrids

, 2016
Coupling of biologically active proteins, for example, enzymes and binding proteins, with metals carries huge potential inherent in the integration of these hybrids with miniaturized electronics, medical devices, and in vivo imaging.
Amihay Freeman (2143642), Gil Mor (2143645), Yael Dror (2143636), Sefi Vernick (2143639), Hila Moscovich-Dagan (2143648)   +4 more
core   +1 more source

Serotonin engages divergent 5‐HT receptor pathways for cell type‐resolved modulation of prefrontal layer 5 microcircuits

British Journal of Pharmacology, Volume 183, Issue 19, Page 5832-5853, October 2026.
Serotonin differentially modulates layer 5 mPFC microcircuits through cell type‐specific pre‐ and postsynaptic receptor pathways. Presynaptic 5‐HT1BRs suppress glutamate and GABA release, whereas presynaptic and postsynaptic 5‐HT3ARs enhance fast‐spiking interneuron activity, whilst distinct pyramidal neuron subtypes exhibit divergent 5‐HT1AR‐ and 5 ...
Ramya Rama, Guanxiao Qi, Gabriele Radnikow, Danqing Yang, Dirk Feldmeyer   +4 more
wiley   +1 more source

Helical Conjugated Polyelectrolyte Aggregation Induced by Biotin–Avidin Interaction

, 2015
Fluorescence correlation spectroscopy (FCS) is applied to demonstrate avidin-induced cross-linking in a system consisting of a helical anionic conjugated polyelectrolyte (P1) and a biotin-tetramethylrhodamine (TMR) conjugate (2).
Yan Chen (4308), Kirk S. Schanze (1273860), Dongping Xie (1286961), Fude Feng (1286886), Danlu Wu (1286958), Weihong Tan (9692)   +5 more
core   +1 more source

Increased CCR5 expression in lymphoma cells and M2 macrophages is associated with poor prognosis in primary intestinal diffuse large B‐cell lymphoma

The Journal of Pathology: Clinical Research, Volume 12, Issue 5, September 2026.
Abstract Few studies have evaluated the impact of organ‐specific tumor microenvironments (TMEs) on clinical outcomes in diffuse large B‐cell lymphoma (DLBCL). This study investigated potential molecular markers, the immune cell composition within the TME, and their associations with clinical outcomes in patients with primary intestinal DLBCL (PI‐DLBCL).
Wei‐Li Ma, Tsai‐Yun Chen, Pei‐An Fu, Jo‐Pai Chen, Ming Yao, Hsiu‐Po Wang, Been‐Ren Lin, Chung‐Wu Lin, Chia‐Lang Hsu, Chung‐Yu Huang, Ann‐Lii Cheng, Sung‐Hsin Kuo   +11 more
wiley   +1 more source