Results 161 to 170 of about 136,886 (329)

T1WI‐SWI Dual Modal Magnetic Resonance Nanoprobes for Accurate Diagnosis of Early Stage Alzheimer's Disease

open access: yesAdvanced Science, Volume 13, Issue 1, 5 January 2026.
We developed a smart MRI nanoprobe targeting BACE1 and Aβ plaques. It crosses the blood‐brain barrier. Upon encountering BACE1, the probe is cleaved, enabling T1WI imaging detection. Subsequent reaction with ONOO− induces probe aggregation, enhancing magnetic susceptibility for sensitive SWI imaging of Aβ plaques.
Minghua Li   +13 more
wiley   +1 more source

THE AVIDIN-BIOTIN EQUILIBRIUM

open access: yesJournal of Biological Chemistry, 1951
H F, LAUNER, H, FRAENKEL-CONRAT
openaire   +2 more sources

Chronic PET‐Microplastic Exposure: Disruption of Gut–Liver Homeostasis and Risk of Hepatic Steatosis

open access: yesAdvanced Science, Volume 13, Issue 1, 5 January 2026.
Chronic exposure to environmentally relevant PET microplastics disrupts gut–liver homeostasis, leading to hepatic steatosis, early fibrosis, and altered gut microbiota. These effects signal metabolic imbalance and gut–liver axis impairment, emphasizing chronic microplastic ingestion as an emerging environmental health risk linked to non‐communicable ...
Surye Park   +5 more
wiley   +1 more source

USP11‐PGAM5 Axis Promotes Neurotoxic Astrocyte Reactivity by Aggravating the mtDNA‐cGAS‐STING Pathway After Intracerebral Hemorrhage

open access: yesAdvanced Science, Volume 13, Issue 1, 5 January 2026.
This study reveals that the deubiquitinase USP11 stabilizes PGAM5, triggering neurotoxic astrocyte transformation after intracerebral hemorrhage. PGAM5 promotes mPTP opening and Drp1 dephosphorylation, synergistically amplifying mtDNA leakage into the cytosol and leading to cGAS–STING hyperactivation.
Jiaqing He   +10 more
wiley   +1 more source

Stromal Cell‐Mast Cell Communication Orchestrates Anti‐Viral Immunity in the Meninges

open access: yesAdvanced Science, Volume 13, Issue 5, 27 January 2026.
This study delineates the spatial distribution and postnatal maturation of meningeal mast cells and uncovers their essential role in antiviral immunity. Using genetic models, mast cells are shown to promote CD8⁺ T cell infiltration and viral clearance via IL‐33 receptor signaling and synergistic activation by IL‐33 and ATP from infected stromal cells ...
Qingqing Li   +7 more
wiley   +1 more source

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