Results 101 to 110 of about 5,247,612 (307)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Rebaudioside D decreases adiposity and hepatic lipid accumulation in a mouse model of obesity

Scientific Reports
Overconsumption of added sugars has been pointed out as a major culprit in the increasing rates of obesity worldwide, contributing to the rising popularity of non-caloric sweeteners.
Arianne Morissette, Alice de Wouters d’Oplinter, Diana Majolli Andre, Marilou Lavoie, Bruno Marcotte, Thibault V. Varin, Jocelyn Trottier, Geneviève Pilon, Martin Pelletier, Patrice D. Cani, Olivier Barbier, Vanessa P. Houde, André Marette   +12 more
doaj   +1 more source

The Mitochondrial Permeability Transition Pore in Platelets: Mechanisms, Physiological Roles, and Therapeutic Perspectives

Antioxidants
Platelets have long been known to be critically involved in hemostasis and thrombosis. However, platelets are also recognized as metabolically active cells that require well-regulated mitochondrial function to support their multiple functions in ...
Chiara Lonobile, Alessia Di Nubila, Rosa Simone, Matilda Hushi, Silvia Stella Barbieri   +4 more
doaj   +1 more source

Axis Screw Fixation – A Step-by-Step Review of the Surgical Techniques

Brazilian Neurosurgery, 2017
In this article, we present the techniques of axis screw fixation (laminar, pars, pedicle and transarticular screws), discussing the indications and contraindications of each one, as well as surgical tips and anatomical landmarks.
Andrei F. Joaquim, K. Daniel Riew
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

The axis ratio distribution of X-ray clusters observed by XMM-Newton

, 2010
We derive the axis ratio distribution of X-ray clusters using the XMM-Newton catalogue (Snowden et al. 2008). By fitting the contour lines of the X-ray image by ellipses, we confirm the X-ray distribution is well approximated by the elliptic distribution
Albrecht, Binney, Binney, Dalal, De Filippis, Evans, Fang, Hajime Kawahara, Jedrzejewski, Jing, Jones, Kasun, Kawahara, Kawahara, Lee, Markevitch, Oguri, Wang, Wang   +18 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Wnt, Ptk7, and FGFRL expression gradients control trunk positional identity in planarian regeneration

eLife, 2016
Mechanisms enabling positional identity re-establishment are likely critical for tissue regeneration. Planarians use Wnt/beta-catenin signaling to polarize the termini of their anteroposterior axis, but little is known about how regeneration signaling ...
Rachel Lander, Christian P Petersen
doaj   +1 more source

PENGARUH MEDIA SIMULATOR CNC 2 AXIS TERHADAP HASIL BELAJAR CNC DASAR PADA SISWA DI SMK ISLAM YOGYAKARTA [PDF]

, 2012
Tujuan dari penelitian ini adalah: (1) mengetahui perbedaan hasil belajar CNC Dasar pada siswa antara kelompok eksperimen yang menggunakan media Simulator CNC 2 Axis dan kelompok kontrol yang tidak menggunakan media pembelajaran di SMK Islam Yogyakarta ...
Sigit Apriantoro , Putro
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source