Capacity of astrocytes to promote axon growth in the injured mammalian central nervous system [PDF]
Frontiers in Neuroscience, 2022 Understanding the regulation of axon growth after injury to the adult central nervous system (CNS) is crucial to improve neural repair. Following acute focal CNS injury, astrocytes are one cellular component of the scar tissue at the primary lesion that ...
Matin Hemati-Gourabi +5 more
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Mechanisms of Axon Growth and Regeneration: Moving between Development and Disease. [PDF]
J Neurosci, 2022 Axons differ in their growth potential: whereas during development, axons rapidly grow to their targets, in the adult mammalian, CNS axons have lost their ability to grow and therefore fail to regenerate.
Bradke F.
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Moving CNS axon growth and regeneration research into human model systems [PDF]
Frontiers in Neuroscience, 2023 Axon regeneration is limited in the adult mammalian central nervous system (CNS) due to both intrinsic and extrinsic factors. Rodent studies have shown that developmental age can drive differences in intrinsic axon growth ability, such that embryonic ...
Bo P. Lear, Darcie L. Moore
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Axonal Organelles as Molecular Platforms for Axon Growth and Regeneration after Injury. [PDF]
Int J Mol Sci, 2021 Investigating the molecular mechanisms governing developmental axon growth has been a useful approach for identifying new strategies for boosting axon regeneration after injury, with the goal of treating debilitating conditions such as spinal cord injury
Petrova V +3 more
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Astroglial exosome HepaCAM signaling and ApoE antagonization coordinates early postnatal cortical pyramidal neuronal axon growth and dendritic spine formation [PDF]
Nature Communications, 2023 Developing astroglia play important roles in regulating synaptogenesis through secreted and contact signals. Whether they regulate postnatal axon growth is unknown. By selectively isolating exosomes using size-exclusion chromatography (SEC) and employing
Shijie Jin +5 more
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Cbln1 regulates axon growth and guidance in multiple neural regions. [PDF]
PLoS Biology, 2022 The accurate construction of neural circuits requires the precise control of axon growth and guidance, which is regulated by multiple growth and guidance cues during early nervous system development.
Peng Han +9 more
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Cytosolic Ptbp2 modulates axon growth in motoneurons through axonal localization and translation of Hnrnpr [PDF]
Nature Communications, 2023 The neuronal RNA-binding protein Ptbp2 regulates neuronal differentiation by modulating alternative splicing programs in the nucleus. Such programs contribute to axonogenesis by adjusting the levels of protein isoforms involved in axon growth and ...
Saeede Salehi +9 more
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eLife, 2016 Mechanistic studies of axon growth during development are beneficial to the search for neuron-intrinsic regulators of axon regeneration. Here, we discovered that, in the developing neuron from rat, Akt signaling regulates axon growth and growth cone ...
Hyo Rim Ko +9 more
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Zeb2 is a negative regulator of midbrain dopaminergic axon growth and target innervation
Scientific Reports, 2017 Neural connectivity requires neuronal differentiation, axon growth, and precise target innervation. Midbrain dopaminergic neurons project via the nigrostriatal pathway to the striatum to regulate voluntary movement.
Shane V. Hegarty +6 more
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A new view of axon growth and guidance grounded in the stochastic dynamics of actin networks [PDF]
Open Biology, 2023 The mechanism of axon growth and guidance is a core, unsolved problem in neuroscience and cell biology. For nearly three decades, our view of this process has largely been based on deterministic models of motility derived from studies of neurons cultured
Rameen Forghani +3 more
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