Results 11 to 20 of about 6,316,330 (345)

The ANC-1 (Nesprin-1/2) organelle-anchoring protein functions through mitochondria to polarize axon growth in response to SLT-1. [PDF]

PLoS Genetics, 2022
A family of giant KASH proteins, including C. elegans ANC-1 and mammalian Nesprin-1 and -2, are involved in organelle anchoring and are associated with multiple neurodevelopmental disorders including autism, bipolar disorder, and schizophrenia.
Nathan C Fischer, Vladislav Friedman, Miguel A Martinez-Reyes, Hongyan Hao, Tamjid A Chowdhury, Daniel A Starr, Christopher C Quinn   +6 more
doaj   +2 more sources

Magnetically-actuated microposts stimulate axon growth. [PDF]

Biophys J, 2022
New strategies to promote neuronal regeneration should aim to increase the speed of axonal elongation. Biochemical signaling is a key factor in axon growth, but recent discoveries have shown that mechanical force, through a process referred to as stretch growth, can significantly influence the elongation rate.
Falconieri A, Taparia N, De Vincentiis S, Cappello V, Sniadecki NJ, Raffa V.   +5 more
europepmc   +4 more sources

Co-occupancy identifies transcription factor co-operation for axon growth [PDF]

Nature Communications, 2021
After injury to the nervous system, many neurons fail to initiate transcriptional programs needed for axon growth. Here the authors examine co-operative binding of factors to regulatory DNA to predict combinations that improve axon growth when ...
Ishwariya Venkatesh, Vatsal Mehra, Zimei Wang, Matthew T. Simpson, Erik Eastwood, Advaita Chakraborty, Zac Beine, Derek Gross, Michael Cabahug, Greta Olson, Murray G. Blackmore   +10 more
doaj   +2 more sources

Amphetamine disrupts dopamine axon growth in adolescence by a sex-specific mechanism in mice. [PDF]

Nat Commun, 2023
Reynolds LM, Hernandez G, MacGowan D, Popescu C, Nouel D, Cuesta S, Burke S, Savell KE, Zhao J, Restrepo-Lozano JM, Giroux M, Israel S, Orsini T, He S, Wodzinski M, Avramescu RG, Pokinko M, Epelbaum JG, Niu Z, Pantoja-Urbán AH, Trudeau LÉ, Kolb B, Day JJ, Flores C.   +23 more
europepmc   +3 more sources

Developmental Axon Stretch Stimulates Neuron Growth While Maintaining Normal Electrical Activity, Intracellular Calcium Flux, and Somatic Morphology

Frontiers in Cellular Neuroscience, 2015
Elongation of nerve fibers intuitively occurs throughout mammalian development, and is synchronized with expansion of the growing body. While most tissue systems enlarge through mitosis and differentiation, elongation of nerve fibers is remarkably ...
Joseph R Loverde, Joseph R Loverde, Bryan J Pfister   +2 more
doaj   +2 more sources

Mechanical Forces Guide Axon Growth through the Nigrostriatal Pathway in an Organotypic Model. [PDF]

Adv Sci (Weinh)
De Vincentiis S, Capitanini E, Kira K, Dell'Amico C, Takahashi J, Onorati M, Raudzus F, Raffa V.   +7 more
europepmc   +3 more sources

The Role of Lipids, Lipid Metabolism and Ectopic Lipid Accumulation in Axon Growth, Regeneration and Repair after CNS Injury and Disease

Cells, 2021
Axons in the adult mammalian nervous system can extend over formidable distances, up to one meter or more in humans. During development, axonal and dendritic growth requires continuous addition of new membrane. Of the three major kinds of membrane lipids,
D. Roy, Andrea Tedeschi
semanticscholar   +1 more source

Axonal Organelles as Molecular Platforms for Axon Growth and Regeneration after Injury

International Journal of Molecular Sciences, 2021
Investigating the molecular mechanisms governing developmental axon growth has been a useful approach for identifying new strategies for boosting axon regeneration after injury, with the goal of treating debilitating conditions such as spinal cord injury
Veselina Petrova, Bart Nieuwenhuis, J. Fawcett, R. Eva   +3 more
semanticscholar   +1 more source

Mimicking Axon Growth and Pruning by Photocatalytic Growth and Chemical Dissolution of Gold on Titanium Dioxide Patterns. [PDF]

Molecules
Abshari F, Paulsen M, Veziroglu S, Vahl A, Gerken M.   +4 more
europepmc   +3 more sources

T-type Ca2+ channels are required for enhanced sympathetic axon growth by TNFα reverse signalling [PDF]

Open Biology, 2017
Tumour necrosis factor receptor 1 (TNFR1)-activated TNFα reverse signalling, in which membrane-integrated TNFα functions as a receptor for TNFR1, enhances axon growth from developing sympathetic neurons and plays a crucial role in establishing ...
Lilian Kisiswa, Clara Erice, Laurent Ferron, Sean Wyatt, Catarina Osório, Annette C. Dolphin, Alun M. Davies   +6 more
doaj   +1 more source