Results 21 to 30 of about 6,093,797 (222)
Extremely Low Forces Induce Extreme Axon Growth
Journal of Neuroscience, 2020 Stretch-growth has been defined as a process that extends axons via the application of mechanical forces. In the present article, we used a protocol based on magnetic nanoparticles (NPs) for labeling the entire axon tract of hippocampal neurons, and an ...
Sara De Vincentiis +9 more
semanticscholar +1 more source
A Simple Method for 3D Analysis of Immunolabeled Axonal Tracts in a Transparent Nervous System
Cell Reports, 2014 Clearing techniques have been developed to transparentize mouse brains, thereby preserving 3D structure, but their complexity has limited their use. Here, we show that immunolabeling of axonal tracts followed by optical clearing with solvents (3DISCO ...
Morgane Belle +7 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2012 Axon growth requires coordinated regulation of gene expression in the neuronal soma, anterograde transport of synthesized raw materials along the axon, and assembly of cytoskeleton and membranes in the nerve growth cone. Glycogen synthase kinase 3 (GSK3)
Fengquan eZhou
doaj +1 more source
N-docosahexaenoylethanolamine regulates Hedgehog signaling and promotes growth of cortical axons
Biology Open, 2015 Axonogenesis, a process for the establishment of neuron connectivity, is central to brain function. The role of metabolites derived from docosahexaenoic acid (DHA, 22:6n-3) that is specifically enriched in the brain, has not been addressed in axon ...
Giorgi Kharebava +5 more
doaj +1 more source
Modeling of interstitial branching of axonal networks [PDF]
1. J. Integr. Neurosci. 12, 1-14, (2013), 2013 A single axon can generate branches connecting with plenty synaptic targets. Process of branching is very important for making connections in central nervous system. The interstitial branching along primary axon shaft occurs during nervous system development. Growing axon makes pause in its movement and leaves active points behind its terminal. The new
arxiv +1 more source
Genome-wide chromatin accessibility analyses provide a map for enhancing optic nerve regeneration
Scientific Reports, 2021 Retinal Ganglion Cells (RGCs) lose their ability to grow axons during development. Adult RGCs thus fail to regenerate their axons after injury, leading to vision loss.
Wolfgang Pita-Thomas +4 more
doaj +1 more source
Deacetylation of Miro1 by HDAC6 blocks mitochondrial transport and mediates axon growth inhibition
Journal of Cell Biology, 2019 Extracellular stimuli in the injured CNS, such as chondroitin sulfate proteoglycans, inhibit axon growth through activation of the small GTPase RhoA.
Ashley L. Kalinski +19 more
semanticscholar +1 more source
eLife, 2019 EphA/ephrin signaling regulates axon growth and guidance of neurons, but whether this process occurs also independently of ephrins is unclear. We show that presenilin-1 (PS1)/γ-secretase is required for axon growth in the developing mouse brain.
Míriam Javier-Torrent +7 more
doaj +1 more source
The sound of an axon's growth [PDF]
Phys. Rev. E 99, 050401 (2019), 2018 Axons are linear processes of nerve cells that can range from a few tens of micrometers up to meters in length. In addition to external cues, the length of an axon is also regulated by unknown internal mechanisms. Molecular motors have been suggested to generate oscillations with an axon length-dependent frequency that could be used to measure an axon ...
arxiv +1 more source
Mechanosensing is critical for axon growth in the developing brain
Nature Neuroscience, 2016 During nervous system development, neurons extend axons along well-defined pathways. The current understanding of axon pathfinding is based mainly on chemical signaling.
David E. Koser +11 more
semanticscholar +1 more source