Results 21 to 30 of about 6,316,330 (345)
p250GAP is a novel player in the Cdh1-APC/Smurf1 pathway of axon growth regulation. [PDF]
PLoS ONE, 2012 Axon growth is an essential process during brain development. The E3 ubiquitin ligase Cdh1-APC has emerged as a critical regulator of intrinsic axon growth control.
Madhuvanthi Kannan +4 more
doaj +1 more source
Integrating Chemistry and Mechanics: The Forces Driving Axon Growth.
Annual Review of Cell and Developmental Biology, 2020 The brain is our most complex organ. During development, neurons extend axons, which may grow over long distances along well-defined pathways to connect to distant targets.
K. Franze
semanticscholar +1 more source
Diltiazem Promotes Regenerative Axon Growth [PDF]
Molecular Neurobiology, 2018 Axotomy results in permanent loss of function after brain and spinal cord injuries due to the minimal regenerative propensity of the adult central nervous system (CNS). To identify pharmacological enhancers of axon regeneration, 960 compounds were screened for cortical neuron axonal regrowth using an in vitro cortical scrape assay. Diltiazem, verapamil,
Eric A. Huebner +14 more
openaire +2 more sources
Commissureless acts as a substrate adapter in a conserved Nedd4 E3 ubiquitin ligase pathway to promote axon growth across the midline. [PDF]
ElifeSullivan KG, Bashaw GJ.
europepmc +3 more sources
Advances in the Signaling Pathways Downstream of Glial-Scar Axon Growth Inhibitors
Frontiers in Cellular Neuroscience, 2020 Axon growth inhibitors generated by reactive glial scars play an important role in failure of axon regeneration after CNS injury in mature mammals. Among the inhibitory factors, chondroitin sulfate proteoglycans (CSPGs) are potent suppressors of axon ...
Armin Sami, M. Selzer, Shuxin Li
semanticscholar +1 more source
Axonal growth and its inhibition [PDF]
Eye, 1994 neu ropil which may be either white or grey matter. Functional regeneration is a corollary defined as the invasion of regenerating fibres into the original or new targets, where synaptic connections are established which restore lost function. Regeneration ofaxons in the mammalian and avian eNS is, however, largely impossible, but the reasons for this
M, Berry, S, Hall, D, Shewan, J, Cohen
openaire +2 more sources
Extremely Low Forces Induce Extreme Axon Growth
Journal of Neuroscience, 2020 Stretch-growth has been defined as a process that extends axons via the application of mechanical forces. In the present article, we used a protocol based on magnetic nanoparticles (NPs) for labeling the entire axon tract of hippocampal neurons, and an ...
Sara De Vincentiis +9 more
semanticscholar +1 more source
A Simple Method for 3D Analysis of Immunolabeled Axonal Tracts in a Transparent Nervous System
Cell Reports, 2014 Clearing techniques have been developed to transparentize mouse brains, thereby preserving 3D structure, but their complexity has limited their use. Here, we show that immunolabeling of axonal tracts followed by optical clearing with solvents (3DISCO ...
Morgane Belle +7 more
doaj +1 more source
cJun promotes CNS axon growth [PDF]
Molecular and Cellular Neuroscience, 2014 A number of genes regulate regeneration of peripheral axons, but their ability to drive axon growth and regeneration in the central nervous system (CNS) remains largely untested. To address this question we overexpressed eight transcription factors and one small GTPase alone and in pairwise combinations to test whether combinatorial overexpression ...
Jessica K, Lerch +3 more
openaire +2 more sources
Frontiers in Molecular Neuroscience, 2012 Axon growth requires coordinated regulation of gene expression in the neuronal soma, anterograde transport of synthesized raw materials along the axon, and assembly of cytoskeleton and membranes in the nerve growth cone. Glycogen synthase kinase 3 (GSK3)
Fengquan eZhou
doaj +1 more source