Results 111 to 120 of about 899,641 (334)
Glycerophospholipid regulation of modality-specific sensory axon guidance in the spinal cord
Science, 2015 Axon paths in developing spinal cords Sensory neurons entering the spinal cord take different paths as inputs for pain and proprioception diverge. Working with chick and mouse embryos, Guy et al.
Adam T Guy +13 more
semanticscholar +1 more source
Upconversion‐Based Remote Deep Brain Modulation for Therapeutic Dissection of Parkinson's Disease
Advanced Therapeutics, EarlyView.An upconversion‐based wireless optogenetic strategy enables an all‐optical deep brain modulation solution for treating Parkinson's disease in rodent animals without using electronics or any tethered cables, providing experimental evidence supporting a therapeutic mechanism of STN‐DBS by disruption of anterograde signal transmission along the indirect ...
Wenchong Zhang +13 more
wiley +1 more source
Myotube Guidance: Shaping up the Musculoskeletal System
Journal of Developmental BiologyMyofibers are highly specialized contractile cells of skeletal muscles, and dysregulation of myofiber morphogenesis is emerging as a contributing cause of myopathies and structural birth defects.
Aaron N. Johnson
doaj +1 more source
Glypican Is a Modulator of Netrin-Mediated Axon Guidance
PLoS Biology, 2015 Netrin is a key axon guidance cue that orients axon growth during neural circuit formation. However, the mechanisms regulating netrin and its receptors in the extracellular milieu are largely unknown.
C. Blanchette +3 more
semanticscholar +1 more source
FUS Selectively Facilitates circRNAs Packing into Small Extracellular Vesicles within Hypoxia Neuron
Advanced Science, EarlyView.This study aimed to unravel the role of FUS in the loading of functional circRNAs into neuronal sEVs under hypoxic conditions, which involves their aggregations in SGs and specific interaction between the FUS Zf_RanBP domain to regulate circRNA sorting in sEVs.
Jiankun Zang +14 more
wiley +1 more source
TAG-1 Multifunctionality Coordinates Neuronal Migration, Axon Guidance, and Fasciculation
Cell Reports, 2020 Summary: Neuronal migration, axon fasciculation, and axon guidance need to be closely coordinated for neural circuit assembly. Spinal motor neurons (MNs) face unique challenges during development because their cell bodies reside within the central ...
Tracey A.C.S. Suter +5 more
doaj
Lab on a Chip, 2015 Understanding how axons are guided to target locations within the brain is of fundamental importance for neuroscience, and is a widely studied area of research. Biologists have an unmet need for reliable and easily accessible methods that generate stable,
Anne Marion Taylor +2 more
semanticscholar +1 more source
α‐Synuclein Pathology Spreads in a Midbrain–Hindbrain Assembloid Model
Advanced Science, EarlyView.A novel midbrain–hindbrain assembloid model demonstrates the spread of α‐synuclein pathology, a hallmark of Parkinson's disease, mimicking Braak's hypothesis. This model reveals how pathology propagates from the hindbrain to the midbrain, inducing synaptic changes and early signs of neuronal vulnerability. It offers an innovative platform for exploring
Gemma Gomez‐Giro +14 more
wiley +1 more source
Signaling mechanisms in cortical axon growth, guidance and branching
Frontiers in Neuroanatomy, 2011 Precise wiring of cortical circuits during development depends upon axon extension, guidance and branching to appropriate targets. Motile growth cones at axon tips navigate through the nervous system by responding to molecular cues, which modulate ...
Katherine eKalil +5 more
doaj +1 more source
The discovery of the growth cone and its influence on the study of axon guidance
Frontiers in Neuroanatomy, 2015 For over a century, there has been a great deal of interest in understanding how neural connectivity is established during development and regeneration.
E. Tamariz, A. Varela-Echavarría
semanticscholar +1 more source