Results 241 to 250 of about 41,593 (291)
Animal Models and Experimental Medicine, EarlyView.At steady state, DRG ensures low‐level expression of TH+ neurons under the protection of AKT. However, the DRG level of PD mouse model under MPTP toxicity increased significantly, and the expression of IL‐6 and CASP3 increased. This process was accompanied by the occurrence of m6A demethylation, with a significant increase in FTO as the main ...
Yatan Li +6 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.We generated two neuron‐specific Cre rat lines, Thy1‐Cre and NeuN‐Cre, using CRISPR/Cas9‐mediated targeted insertion. Both lines were validated for high neural specificity by crossing them with a Cre reporter rat. When bred with an ND1 conditional knockout rat, the two Cre lines produced distinct phenotypic outcomes. These rat lines have been deposited
Keru Li +15 more
wiley +1 more source
A Chemoattractant Role for NT-3 in Proprioceptive Axon Guidance
, 2004 Barış Genç +3 more
openalex +2 more sources
Research advances in dysphagia animal models
Animal Models and Experimental Medicine, EarlyView.This review systematically summarizes the establishment, evaluation, and detection of dysphagia animal models in stroke, Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS) in three kinds of experimental animals (including rodents, nonhuman primates, and other mammals), providing a basis for the selection of appropriate animal models of ...
Junhui Bai +5 more
wiley +1 more source
Mucopolysaccharidosis type II zebrafish model exhibits early impaired proteasomal-mediated degradation of the axon guidance receptor Dcc. [PDF]
Cell Death DisManzoli R +7 more
europepmc +1 more source
Animal Models and Experimental Medicine, EarlyView.Post‐stroke depression (PSD) animal model of traditional Chinese medicine (TCM) combined with disease and syndrome often uses western medicine surgery (including: middle cerebral artery embolization to construct cerebral ischemia, or brain injection of collagenase to construct cerebral hemorrhage) combined with other methods (including: isolation ...
Jielin Wang +4 more
wiley +1 more source
Astrocytes of the Anterior Commissure Regulate the Axon Guidance Pathways of Newly Generated Neocortical Neurons in the Opossum Monodelphis domestica. [PDF]
Int J Mol SciBartkowska K +3 more
europepmc +1 more source
Annals of Neurology, EarlyView.Objective Elezanumab is a monoclonal antibody that binds repulsive guidance molecule a (RGMa), an inhibitor of central nervous system regeneration after inflammation or injury. The aim was to assess the safety and efficacy of elezanumab in relapsing and progressive forms of multiple sclerosis (MS).
Bruce A.C. Cree +6 more
wiley +1 more source
Water‐Soluble Molecular Wires for Membrane Potential Imaging
Angewandte Chemie, EarlyView.Fully water‐soluble fluorescent rosamine‐based amphiphilic molecular wires were developed for imaging membrane potentials. The performance of the probes was evaluated in single cardiomyocytes, murine pituitary gland, and islets of Langerhans.
Mirna El Khatib +9 more
wiley +2 more sources
Annals of Neurology, EarlyView.Synthesis of Literature: Neurodegeneration in Moderate‐Severe TBI. Objective Although moderate‐to‐severe traumatic brain injury (msTBI) was once considered a static neural event following resolution of acute injuries, numerous studies now demonstrate progressive losses to volume and white matter integrity in the months and years postinjury, leading to ...
Bhanu Sharma +4 more
wiley +1 more source