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Axonal Guidance: Making Connections
2016The vertebrate brain contains millions of neuronal and glial cells arranged in a highly organized manner forming functional neural circuits. To form these circuits during brain development, neurons extend an axon from the cell body to make connections with neurons in target brain areas, which can be a considerable distance away from the neuronal cell ...
Kozulin, Peter, Richards, Linda
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The Molecular Biology of Axon Guidance
Science, 1996Neuronal growth cones navigate over long distances along specific pathways to find their correct targets. The mechanisms and molecules that direct this pathfinding are the topics of this review. Growth cones appear to be guided by at least four different mechanisms: contact attraction, chemoattraction, contact repulsion, and chemorepulsion. Evidence is
M, Tessier-Lavigne, C S, Goodman
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Repellent cues in axon guidance
Current Opinion in Neurobiology, 1992There is increasing evidence that axons are guided by repulsion in several regions of the developing nervous system, although this has yet to be confirmed directly in vivo. As more candidate repulsion molecules are identified, it is becoming clear that collapse of the growth cone in vitro may be mediated by more than one intracellular mechanism.
R J, Keynes, G M, Cook
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Wnt signaling in axon guidance
Trends in Neurosciences, 2004Recent studies have identified Wnt proteins as conserved axon guidance molecules in vertebrates and invertebrates. Wnt proteins are a large family of diffusible factors that play several important roles, both in embryonic development and in adult function.
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Axonal guidance in the chicken retina
Development, 1995ABSTRACT During retina development, ganglion cells extend their axons exclusively into the innermost tissue layer, but not into outer retina layers. In order to elucidate guiding mechanisms for axons, tissue strips of embryonic chicken retinae were explanted onto retinal cryosections (cryoculture).
H, Stier, B, Schlosshauer
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Axon Guidance in the Dopamine System
2009Meso-diencephalic dopamine neurons (mdDA) neurons are located in the retrorubral field (RRF), substantia nigra pars compacta (SNc) and ventral tegmental area (VTA) and give rise to prominent ascending axon projections. These so-called mesotelencephalic projections are organized into three main pathways: the mesostriatal, mesocortical and mesolimbic ...
Asheeta A, Prasad, R Jeroen, Pasterkamp
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Axon guidance by molecular gradients
Current Opinion in Neurobiology, 1992In the past year, evidence indicating that some developing axons are guided to their targets, at least in part, by gradients of diffusible chemoattractants secreted by their target cells has continued to accumulate. It has also been shown for the first time that axons can orient in response to smooth gradients of immobilized substrate molecules.
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Unraveling Axon Guidance during Axotomy and Regeneration
International Journal of Molecular Sciences, 2021MIGUEL E DomÃnguez-Romero +1 more
exaly