Results 201 to 210 of about 1,064,643 (248)
Epilepsia Open, EarlyView.Abstract Objectives The objectives of this study were to develop a real‐world‐data (RWD) database for patients with epilepsy to provide further real‐world‐evidence (RWE) for monogenic genetic epilepsies; to assess the usefulness of a diagnostic algorithm in epilepsy; and to examine protein 3D structures using in silico tools to predict variant ...
Haley Morris +4 more
wiley +1 more source
Epilepsia Open, EarlyView.Abstract Objective Individuals with Down syndrome (DS) face an ultra‐high risk of Alzheimer's disease (AD). Within this continuum, Progressive Myoclonus Epilepsy (PME) has emerged as a marker of advanced neurodegeneration. Building on our 2014 characterization of this syndrome, we aimed to define its long‐term natural history and pathological substrate.
Giuseppe d'Orsi +6 more
wiley +1 more source
Leptin Reduces Running in a Rodent Anorexia Nervosa Model via a Distributed Neural Network
European Eating Disorders Review, EarlyView.ABSTRACT Objective Hyperactivity is a persistent and clinically relevant symptom in anorexia nervosa (AN). Hyperactivity is inversely correlated with leptin levels. While systemic leptin administration attenuates hyperactivity in rodent models, the specific brain regions mediating this effect remain unclear.
Nick J. M. Papavoine +6 more
wiley +1 more source
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Roles of axon guidance molecules in neuronal wiring in the developing spinal cord
Nature Reviews Neuroscience, 2019Alain Chedotal, Chedotal Alain
exaly +2 more sources
The Molecular Biology of Axon Guidance
Science, 1996Neuronal growth cones navigate over long distances along specific pathways to find their correct targets. The mechanisms and molecules that direct this pathfinding are the topics of this review. Growth cones appear to be guided by at least four different mechanisms: contact attraction, chemoattraction, contact repulsion, and chemorepulsion. Evidence is
M. Tessier-Lavigne, C. Goodman
semanticscholar +3 more sources
Neurogenesis, neuronal migration, and axon guidance.
Handbook of Clinical Neurology, 2020Development of the central nervous system (CNS) is a complex, dynamic process that involves a precisely orchestrated sequence of genetic, environmental, biochemical, and physical factors from early embryonic stages to postnatal life.
A. Accogli +2 more
semanticscholar +1 more source
Cell and Tissue Research, 1997
The segmental arrangement of spinal nerves in higher vertebrate embryos provides a simple system in which to study the factors that influence axon pathfinding. Developing motor and sensory axons are intimately associated with surrounding tissues that direct axon guidance. We argue that two distinct guidance mechanisms, viz.
, Tannahill, , Cook, , Keynes
openaire +3 more sources
The segmental arrangement of spinal nerves in higher vertebrate embryos provides a simple system in which to study the factors that influence axon pathfinding. Developing motor and sensory axons are intimately associated with surrounding tissues that direct axon guidance. We argue that two distinct guidance mechanisms, viz.
, Tannahill, , Cook, , Keynes
openaire +3 more sources
Cellular Migration and Formation of Axons and Dendrites, 2020
Circumferential axon migrations toward and away from the midline are a major feature of the development of all bilateral animals. Prominent among the guidance cues regulating midline guidance are Netrins, a small family of secreted proteins that have a ...
M. Tessier-Lavigne
semanticscholar +1 more source
Circumferential axon migrations toward and away from the midline are a major feature of the development of all bilateral animals. Prominent among the guidance cues regulating midline guidance are Netrins, a small family of secreted proteins that have a ...
M. Tessier-Lavigne
semanticscholar +1 more source
European Journal of Neuroscience, 1997
AbstractAxon guidance by target‐derived diffusible factors plays an important role in the development of the nervous system. This paper considers the constraints imposed on this process by the mathematics of diffusion. A point source continuously producing a factor into an infinite three‐dimensional volume is considered as a model for both the in vivo ...
openaire +5 more sources
AbstractAxon guidance by target‐derived diffusible factors plays an important role in the development of the nervous system. This paper considers the constraints imposed on this process by the mathematics of diffusion. A point source continuously producing a factor into an infinite three‐dimensional volume is considered as a model for both the in vivo ...
openaire +5 more sources
Current Opinion in Neurobiology, 2006
Our knowledge about molecular mechanisms underlying axon guidance along the antero-posterior axis in contrast to the dorso-ventral axis of the developing nervous system is very limited. During the past two years in vitro and in vivo studies have indicated that morphogens have a role in longitudinal axon guidance.
openaire +4 more sources
Our knowledge about molecular mechanisms underlying axon guidance along the antero-posterior axis in contrast to the dorso-ventral axis of the developing nervous system is very limited. During the past two years in vitro and in vivo studies have indicated that morphogens have a role in longitudinal axon guidance.
openaire +4 more sources