Results 211 to 220 of about 1,064,643 (248)

Axon guidance

2012
The establishment of complex neuronal circuits is critically dependent on axon guidance. The function of differentiated neurons is predicated on correct axon guidance, and is usually distinguished from the subsequent developmental stages of target recognition and synapse formation.
Piper, Michael J., Keynes, Roger J., Cook, Geoffrey M. W.   +2 more
openaire   +4 more sources

Molecular Mechanisms of Axon Guidance

Science, 2002
Axons are guided along specific pathways by attractive and repulsive cues in the extracellular environment. Genetic and biochemical studies have led to the identification of highly conserved families of guidance molecules, including netrins, Slits, semaphorins, and ephrins.
openaire   +5 more sources

Calcium signaling in axon guidance

Trends in Neurosciences, 2014
Guidance of axons to their targets in the developing nervous system requires a myriad of downstream signaling molecules to coordinate growth cone movement. One of the most important of these is calcium, and over the past few years many new insights have been gained into the role of calcium in axon guidance.
Sutherland, Daniel J., Pujic, Zac, Goodhill, Geoffrey J.   +2 more
openaire   +5 more sources

Axon guidance: the cytoplasmic tail

Current Opinion in Cell Biology, 2002
Recent advances in the study of axon guidance have begun to clarify the intricate signalling mechanisms utilised by receptors that mediate path-finding. Many of these axon guidance receptors, including Plexin B, EphA, ephrin B and Robo, regulate the Rho family of GTPases, to effect changes in motility. Recent studies demonstrate a critical role for the
Bharatkumar N, Patel, David L, Van Vactor   +1 more
exaly   +3 more sources

Roles and Mechanisms of Axon-Guidance Molecules in Alzheimer’s Disease

Molecular Neurobiology, 2021
Lei Zhang, Zhipeng Qi, Jiashuo Li, Minghui Li, Xianchao Du, Shuang Wang, Guoyu Zhou, Bin Xu, Wei Liu, Shuhua Xi, Zhaofa Xu, Yu Deng   +11 more
semanticscholar   +1 more source

Axonal Guidance: Making Connections

2016
The vertebrate brain contains millions of neuronal and glial cells arranged in a highly organized manner forming functional neural circuits. To form these circuits during brain development, neurons extend an axon from the cell body to make connections with neurons in target brain areas, which can be a considerable distance away from the neuronal cell ...
Kozulin, Peter, Richards, Linda
openaire   +4 more sources

Repellent cues in axon guidance

Current Opinion in Neurobiology, 1992
There is increasing evidence that axons are guided by repulsion in several regions of the developing nervous system, although this has yet to be confirmed directly in vivo. As more candidate repulsion molecules are identified, it is becoming clear that collapse of the growth cone in vitro may be mediated by more than one intracellular mechanism.
R J, Keynes, G M, Cook
openaire   +2 more sources

Wnt signaling in axon guidance

Trends in Neurosciences, 2004
Recent studies have identified Wnt proteins as conserved axon guidance molecules in vertebrates and invertebrates. Wnt proteins are a large family of diffusible factors that play several important roles, both in embryonic development and in adult function.
openaire   +2 more sources

Axonal guidance in the chicken retina

Development, 1995
ABSTRACT During retina development, ganglion cells extend their axons exclusively into the innermost tissue layer, but not into outer retina layers. In order to elucidate guiding mechanisms for axons, tissue strips of embryonic chicken retinae were explanted onto retinal cryosections (cryoculture).
H, Stier, B, Schlosshauer
openaire   +2 more sources

Axon Guidance in the Dopamine System

2009
Meso-diencephalic dopamine neurons (mdDA) neurons are located in the retrorubral field (RRF), substantia nigra pars compacta (SNc) and ventral tegmental area (VTA) and give rise to prominent ascending axon projections. These so-called mesotelencephalic projections are organized into three main pathways: the mesostriatal, mesocortical and mesolimbic ...
Asheeta A, Prasad, R Jeroen, Pasterkamp
openaire   +2 more sources