Results 211 to 220 of about 50,714 (254)
WONOEP XVII appraisal: The role of the extracellular matrix in epilepsy
Epilepsia, EarlyView.Abstract The extracellular matrix (ECM) is composed of proteoglycans and glycoproteins that regulate the external environment surrounding neurons, glia, and the vascular system. The ECM is vital for maintaining the structure and function of the brain and also acts as a reservoir for various signaling molecules and neurotransmitters, modulating synaptic
Eleonora Lugara +7 more
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Cell and Tissue Research, 1997
The segmental arrangement of spinal nerves in higher vertebrate embryos provides a simple system in which to study the factors that influence axon pathfinding. Developing motor and sensory axons are intimately associated with surrounding tissues that direct axon guidance. We argue that two distinct guidance mechanisms, viz.
, Tannahill, , Cook, , Keynes
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The segmental arrangement of spinal nerves in higher vertebrate embryos provides a simple system in which to study the factors that influence axon pathfinding. Developing motor and sensory axons are intimately associated with surrounding tissues that direct axon guidance. We argue that two distinct guidance mechanisms, viz.
, Tannahill, , Cook, , Keynes
openaire +3 more sources
European Journal of Neuroscience, 1997
AbstractAxon guidance by target‐derived diffusible factors plays an important role in the development of the nervous system. This paper considers the constraints imposed on this process by the mathematics of diffusion. A point source continuously producing a factor into an infinite three‐dimensional volume is considered as a model for both the in vivo ...
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AbstractAxon guidance by target‐derived diffusible factors plays an important role in the development of the nervous system. This paper considers the constraints imposed on this process by the mathematics of diffusion. A point source continuously producing a factor into an infinite three‐dimensional volume is considered as a model for both the in vivo ...
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Current Opinion in Neurobiology, 2006
Our knowledge about molecular mechanisms underlying axon guidance along the antero-posterior axis in contrast to the dorso-ventral axis of the developing nervous system is very limited. During the past two years in vitro and in vivo studies have indicated that morphogens have a role in longitudinal axon guidance.
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Our knowledge about molecular mechanisms underlying axon guidance along the antero-posterior axis in contrast to the dorso-ventral axis of the developing nervous system is very limited. During the past two years in vitro and in vivo studies have indicated that morphogens have a role in longitudinal axon guidance.
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Molecular Mechanisms of Axon Guidance
Science, 2002Axons are guided along specific pathways by attractive and repulsive cues in the extracellular environment. Genetic and biochemical studies have led to the identification of highly conserved families of guidance molecules, including netrins, Slits, semaphorins, and ephrins.
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2012
The establishment of complex neuronal circuits is critically dependent on axon guidance. The function of differentiated neurons is predicated on correct axon guidance, and is usually distinguished from the subsequent developmental stages of target recognition and synapse formation.
Piper, Michael J. +2 more
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The establishment of complex neuronal circuits is critically dependent on axon guidance. The function of differentiated neurons is predicated on correct axon guidance, and is usually distinguished from the subsequent developmental stages of target recognition and synapse formation.
Piper, Michael J. +2 more
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Axon guidance: the cytoplasmic tail
Current Opinion in Cell Biology, 2002Recent advances in the study of axon guidance have begun to clarify the intricate signalling mechanisms utilised by receptors that mediate path-finding. Many of these axon guidance receptors, including Plexin B, EphA, ephrin B and Robo, regulate the Rho family of GTPases, to effect changes in motility. Recent studies demonstrate a critical role for the
Bharatkumar N, Patel +1 more
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Calcium signaling in axon guidance
Trends in Neurosciences, 2014Guidance of axons to their targets in the developing nervous system requires a myriad of downstream signaling molecules to coordinate growth cone movement. One of the most important of these is calcium, and over the past few years many new insights have been gained into the role of calcium in axon guidance.
Sutherland, Daniel J. +2 more
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Guidance of retinal axons in mammals
Seminars in Cell & Developmental Biology, 2019In order to navigate through the surrounding environment many mammals, including humans, primarily rely on vision. The eye, composed of the choroid, sclera, retinal pigmented epithelium, cornea, lens, iris and retina, is the structure that receives the light and converts it into electrical impulses.
Herrera, Eloisa +2 more
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