Results 51 to 60 of about 104,244 (349)
Regulation of CNS and motor axon guidance in Drosophila by the receptor tyrosine phosphatase DPTP52F [PDF]
, 2001 Receptor-linked protein tyrosine phosphatases (RPTPs) regulate axon guidance and synaptogenesis in Drosophila embryos and larvae. We describe DPTP52F, the sixth RPTP to be discovered in Drosophila.
Knirr, Matthias +3 more
core
Structural Perspectives on Axon Guidance
Annual Review of Cell and Developmental Biology, 2016 Axon guidance relies on a combinatorial code of receptor and ligand interactions that direct adhesive/attractive and repulsive cellular responses. Recent structural data have revealed many of the molecular mechanisms that govern these interactions and enabled the design of sophisticated mutant tools to dissect their biological functions.
Seiradake, E, Jones, E, Klein, R
openaire +3 more sources
Annals of Clinical and Translational Neurology, EarlyView.Longitudinal changes in salivary biomarkers in Parkinson’s disease (PD) from early (T0) to 4‐year follow‐up (T1), quantified by ELISA: oligomeric and total α‐synuclein, total and phosphorylated tau, MAP1LC3B (autophagy), and TNFa (inflammation). Blue arrows indicate direction of change at T1 vs T0 (up = increase; down = decrease).
Maria Ilenia De Bartolo +13 more
wiley +1 more source
Venous endothelin modulates responsiveness of cardiac sympathetic axons to arterial semaphorin
eLife, 2019 Developing neurons of the peripheral nervous system reach their targets via cues that support directional growth, a process known as axon guidance.
Denise M Poltavski +5 more
doaj +1 more source
Regulation of axon repulsion by MAX-1 SUMOylation and AP-3. [PDF]
, 2018 During neural development, growing axons express specific surface receptors in response to various environmental guidance cues. These axon guidance receptors are regulated through intracellular trafficking and degradation to enable navigating axons to ...
Chen, Shih-Yu +6 more
core
Activity-dependent competition regulates motor neuron axon pathfinding via PlexinA3 [PDF]
, 2013 The role of electrical activity in axon guidance has been extensively studied in vitro. To better understand its role in the intact nervous system, we imaged intracellular Ca2+ in zebrafish primary motor neurons (PMN) during axon pathfinding in vivo.
Nicol, Xavier +2 more
core +2 more sources
INF2‐Related Charcot–Marie–Tooth Disease in a Japanese Cohort: Genetic and Clinical Insights
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background INF2 mutations cause focal segmental glomerulosclerosis (FSGS) and Charcot–Marie–Tooth disease (CMT). Accurate genetic diagnosis is critical, as INF2‐related FSGS is typically resistant to immunotherapy yet rarely recurs after transplantation, and its associated neuropathy can mimic treatable immune‐mediated disorders such as ...
Chikashi Yano +27 more
wiley +1 more source
Prolyl Isomerase Pin1 Regulates Axon Guidance by Stabilizing CRMP2A Selectively in Distal Axons
Cell Reports, 2015 Axon guidance relies on precise translation of extracellular signal gradients into local changes in cytoskeletal dynamics, but the molecular mechanisms regulating dose-dependent responses of growth cones are still poorly understood.
Martin Balastik +15 more
doaj +1 more source
A developmental timing switch promotes axon outgrowth independent of known guidance receptors. [PDF]
PLoS Genetics, 2010 To form functional neuronal connections, axon outgrowth and guidance must be tightly regulated across space as well as time. While a number of genes and pathways have been shown to control spatial features of axon development, very little is known about ...
Katherine Olsson-Carter, Frank J Slack
doaj +1 more source
Differences in protein mobility between pioneer versus follower growth cones [PDF]
, 2007 Navigating growth cones need to integrate, process and respond to guidance signals, requiring dynamic information transfer within and between different compartments.
Bak +25 more
core +3 more sources