Results 51 to 60 of about 102,974 (302)

Guidance Molecules in Axon Regeneration [PDF]

Cold Spring Harbor Perspectives in Biology, 2010
The regenerative capacity of injured adult mammalian central nervous system (CNS) tissue is very limited. Disease or injury that causes destruction or damage to neuronal networks typically results in permanent neurological deficits. Injury to the spinal cord, for example, interrupts vital ascending and descending fiber tracts of spinally projecting ...
Roman J, Giger, Edmund R, Hollis, Mark H, Tuszynski   +2 more
openaire   +2 more sources

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Prolyl Isomerase Pin1 Regulates Axon Guidance by Stabilizing CRMP2A Selectively in Distal Axons

Cell Reports, 2015
Axon guidance relies on precise translation of extracellular signal gradients into local changes in cytoskeletal dynamics, but the molecular mechanisms regulating dose-dependent responses of growth cones are still poorly understood.
Martin Balastik, Xiao Zhen Zhou, Meritxell Alberich-Jorda, Romana Weissova, Jakub Žiak, Maria F. Pazyra-Murphy, Katharina E. Cosker, Olga Machonova, Iryna Kozmikova, Chun-Hau Chen, Lucia Pastorino, John M. Asara, Adam Cole, Calum Sutherland, Rosalind A. Segal, Kun Ping Lu   +15 more
doaj   +1 more source

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Delta protocadherin 10 is regulated by activity in the mouse main olfactory system

Frontiers in Neural Circuits, 2011
Olfactory sensory neurons (OSNs) are thought to use activity-dependent and independent mechanisms to regulate the expression of axon guidance genes. However, defining the molecular mechanisms that underlie activity-dependent OSN guidance has remained ...
Eric O Williams, Heather M Sickles, Alison L Dooley, Sierra ePalumbos, Adam J Bisogni, David M Lin   +5 more
doaj   +1 more source

Extracellular matrix regulates UNC-6 (netrin) axon guidance by controlling the direction of intracellular UNC-40 (DCC) outgrowth activity. [PDF]

PLoS ONE, 2014
How extracellular molecules influence the direction of axon guidance is poorly understood. The HSN axon of Caenorhabditis elegans is guided towards a ventral source of secreted UNC-6 (netrin). The axon's outgrowth response to UNC-6 is mediated by the UNC-
Yong Yang, Won Suk Lee, Xia Tang, William G Wadsworth   +3 more
doaj   +1 more source

Predicting Axonal Response to Molecular Gradients with a Computational Model of Filopodial Dynamics [PDF]

, 2004
Axons are often guided to their targets in the developing nervous system by attractive or repulsive molecular concentration gradients. We propose a computational model for gradient sensing and directed movement of the growth cone mediated by filopodia ...
Caton A., Hong K., Meinhardt H., Patel K.   +3 more
core   +3 more sources

Fluid and Neuroimaging Biomarkers in Microgliopathy Colony‐Stimulating Factor‐1 Receptor‐Related Disorders

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective This study aims to identify both fluid and neuroimaging biomarkers for CSF1R‐RD that can inform the optimal timing of treatment administration to maximize therapeutic benefit, while also providing sensitive quantitative measurements to monitor disease progression.
Tomasz Chmiela, Madison Reeves, Karen Jansen‐West, Judith Dunmore, Yuping Song, Audrey Strongosky, Sunil Gandhi, Gilana Pikover, Matt Blurton‐Jones, Robert C. Spitale, Erik H. Middlebrooks, Leonard Petrucelli, Mercedes Prudencio, Zbigniew K. Wszolek   +13 more
wiley   +1 more source

SnapShot: Axon Guidance II

Cell, 2013
BMP SE Repulsion BMP-RIB, BMP-RII - -COFILIN, LIMK1, PI3K, SMAD1, SMAD6DRAXIN SE Repulsion DCC - - -EPHRINA GPI Repulsion EPHA ADAM10 -a2-CHIMAERIN, EPHEXIN-1, NCK1/2, RAC1, RHOA, SPAR, VAV2/3EPHRINB TM Repulsion EPHB MMP2/9 -NCK1, PAK, p120GAP, RHOA, ROCK, VAV2/3EPHATM Repulsion EPHRINA ADAM10 P75 FYNAttraction EPHRINA - RET -EPHB TM Repulsion EPHRINB
Kolodkin, Alex L., Pasterkamp, R. Jeroen
openaire   +2 more sources

Axon Guidance: Comm Hither, Robo [PDF]

Current Biology, 2002
In the developing CNS, commissural axons are initially attracted to the midline, but after crossing they acquire sensitivity to midline repellent cues which prevent re-crossing. Recent studies have shed new light on the mechanism by which commissural axons change their sensitivity to guidance cues after crossing the midline.
Couch, Jessica, Condron, Barry
openaire   +2 more sources