Results 101 to 110 of about 769,118 (313)

Lycium barbarum Glycopeptide Alleviates Neomycin‐Induced Ototoxicity by Inhibiting Tryptophan Hydroxylase‐Mediated Serotonin Biosynthesis

Advanced Science, EarlyView.
Lycium barbarum glycopeptide (LBGP), which is further extracted from Lycium barbarum polysaccharides, exhibits significant protective effects against neomycin‐induced hearing dysfunction including oxidative stress in cochlea and loss of key cells in cochlea.
Yunhao Wu, Li Zhang, Shengda Cao, Jingwen Zhang, Cheng Li, Yunlong Shan, Qiuping Liu, Zhexiong Yu, Qiaojun Fang, Yuhua Zhang, Xiaolong Fu, Kwok‐Fai So, Renjie Chai   +12 more
wiley   +1 more source

Marcks overexpression in retinal ganglion cells promotes optic nerve regeneration

Cell Death and Disease
Regeneration of injured central nervous system (CNS) axons is highly restricted, leading to permanent neurological deficits. The myristoylated alanine-rich C-kinase substrate (MARCKS) is a membrane-associated protein kinase C (PKC) substrate ubiquitously
Xue-Qi Peng, Yan-Zhong Li, Chen Gu, Xuan-Cheng He, Chang-Ping Li, Yong-Quan Sun, Hong-Zhen Du, Zhao-Qian Teng, Chang-Mei Liu   +8 more
doaj   +1 more source

The Microtubule Minus-End-Binding Protein Patronin/PTRN-1 Is Required for Axon Regeneration in C. elegans

Cell Reports, 2014
Precise regulation of microtubule (MT) dynamics is increasingly recognized as a critical determinant of axon regeneration. In contrast to developing neurons, mature axons exhibit noncentrosomal microtubule nucleation.
Marian Chuang, Alexandr Goncharov, Shaohe Wang, Karen Oegema, Yishi Jin, Andrew D. Chisholm   +5 more
doaj   +1 more source

Microglia Are Irrelevant for Neuronal Degeneration and Axon Regeneration after Acute Injury

Journal of Neuroscience, 2017
The role of microglia in degenerative and regenerative processes after damage of the nervous system remains ambiguous, partially due to the paucity of appropriate investigative methods.
A. Hilla, H. Diekmann, D. Fischer
semanticscholar   +1 more source

Nanotherapy for Neural Retinal Regeneration

Advanced Science, EarlyView.
Nanotechnology enhances ophthalmic treatments by improving drug delivery and regenerating ocular tissues, combating vision loss from retinal diseases through innovative nano‐systems. This review outlines ocular anatomy, pathology, immune microenvironment, and barriers, detailing nanocarrier characteristics, classification, and preparation methods, and ...
Chuyao Yu, Li Dong, Yujia Lv, Xuhan Shi, Ruiheng Zhang, Wenda Zhou, Haotian Wu, Heyan Li, Yitong Li, Zhou Li, Dan Luo, Wen‐Bin Wei   +11 more
wiley   +1 more source

The appearance of phagocytic microglia in the postnatal brain of Niemann Pick type C mice is developmentally regulated and underscores shortfalls in fine odor discrimination

Journal of Cellular Physiology, Volume 237, Issue 12, Page 4563-4579, December 2022., 2022
Abstract The loss of NPC1 or NPC2 function results in cholesterol and sphingolipid dyshomeostasis that impairs developmental trajectories, predisposing the postnatal brain to the appearance of pathological signs, including progressive and stereotyped Purkinje cell loss and microgliosis.
Alessandro Rava, Piergiorgio La Rosa, Giampiero Palladino, Jessica Dragotto, Antonio Totaro, Jessica Tiberi, Sonia Canterini, Sergio Oddi, Maria Teresa Fiorenza   +8 more
wiley   +1 more source

Gene Ontology (GO) Prediction using Machine Learning Methods [PDF]

arXiv, 2017
We applied machine learning to predict whether a gene is involved in axon regeneration. We extracted 31 features from different databases and trained five machine learning models. Our optimal model, a Random Forest Classifier with 50 submodels, yielded a test score of 85.71%, which is 4.1% higher than the baseline score.
arxiv  

Electrical Stimulation Therapy – Dedicated to the Perfect Plastic Repair

Advanced Science, EarlyView.
This review discusses various types of electrical stimulation sources and materials, delving into the roles and mechanisms of electrical stimulation therapy in plastic surgery for tissue repair. This work broadens the clinical perspective of electrical stimulation, covering diverse repair needs from bone to soft tissues, and provides insights into ...
Kexin Deng, Ruizeng Luo, Ying Chen, Xiaoqiang Liu, Yuanyin Xi, Muhammad Usman, Xupin Jiang, Zhou Li, Jiaping Zhang   +8 more
wiley   +1 more source

Advances in Symbiotic Bioabsorbable Devices

Advanced Science, EarlyView.
This review focuses on recent advances in bioabsorbable devices. This review concludes innovation at the material, device, and system levels, the significant advances toward biomedical applications. This review discusses and highlights the challenges and trends in symbiotic bioresorbable electronics, and provides a new direction for the development of ...
Chang Zhu, Engui Wang, Zhou Li, Han Ouyang   +3 more
wiley   +1 more source

Bioadhesive Graft-Antenna for Stimulation and Repair of Peripheral Nerves [PDF]

arXiv, 2018
Peripheral nerve injuries are difficult to treat due to limited axon regeneration; brief electrical stimulation of injured nerves is an emerging therapy that can relieve pain and enhance regeneration. We report an original wireless stimulator based on a metal loop (diameter ~1 mm) that is powered by a transcranial magnetic stimulator (TMS).
arxiv