Results 111 to 120 of about 938,041 (332)

Axonal mRNA in Uninjured and Regenerating Cortical Mammalian Axons [PDF]

The Journal of Neuroscience, 2009
Using a novel microfluidic chamber that allows the isolation of axons without contamination by nonaxonal material, we have for the first time purified mRNA from naive, matured CNS axons, and identified the presence of >300 mRNA transcripts. We demonstrate that the transcripts are axonal in nature, and that many of the transcripts present in ...
Anne M, Taylor, Nicole C, Berchtold, Victoria M, Perreau, Christina H, Tu, Noo, Li Jeon, Carl W, Cotman   +5 more
openaire   +2 more sources

Timed GDNF gene therapy using an immune-evasive gene switch promotes long distance axon regeneration

Brain : a journal of neurology, 2019
Neurosurgical repair in patients with proximal nerve lesions results in unsatisfactory recovery of function. Gene therapy for neurotrophic factors is a powerful strategy to promote axon regeneration.
R. Eggers, F. de Winter, S. Hoyng, R. Hoeben, M. Malessy, M. Tannemaat, J. Verhaagen   +6 more
semanticscholar   +1 more source

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

Gene therapy for axon regeneration

, 2019
Injury to the brain and spinal cord has devastating consequences because adult neurons in the central nervous system (CNS) do not regenerate. Traumatic CNS injuries are a significant clinical problem and have life-changing consequences for patients ...

core   +1 more source

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

Advanced Science, EarlyView.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source

Histone methyltransferase Ezh2 coordinates mammalian axon regeneration via regulation of key regenerative pathways

The Journal of Clinical Investigation
Current treatments for neurodegenerative diseases and neural injuries face major challenges, primarily due to the diminished regenerative capacity of neurons in the mammalian CNS as they mature.
Xue-Wei Wang, Shu-Guang Yang, Ming-Wen Hu, Rui-Ying Wang, Chi Zhang, Anish R. Kosanam, Arinze J. Ochuba, Jing-Jing Jiang, Ximei Luo, Yun Guan, Jiang Qian, Chang-Mei Liu, Feng-Quan Zhou   +12 more
doaj   +1 more source

Nanomaterials for promoting axon regeneration after spinal cord injury: Mechanisms and prospects

Interdisciplinary Medicine
The establishment of new functional connections through axon regeneration is essential for functional recovery following spinal cord injury (SCI). With the rapid advancement of nanotechnology, nanomaterial (NM)‐based therapies have emerged as promising ...
Jia Liu, Zhendong Huang, Xiner Tan, Wei Du, Ziyang Wang, Xinru Zhou, Hao Pan, Lili Chen, Yiyuan Kang, Longquan Shao   +9 more
doaj   +1 more source

Macrophages warrant Mauthner cell axon regrowth by preventing late-stage hyperglycemia in zebrafish [PDF]

Open Biology
Axonal regeneration in the central nervous system is imperative for functional restoration following spinal cord injury (SCI). Myeloid cells are key regulators of axonal regeneration, yet their roles are not fully revealed.
Jing Bai, Siting Lai, Yubei Huang, Jixiang Liu, Zhujuan Huang, Jin Xu   +5 more
doaj   +1 more source

Intrinsic control of axon regeneration [PDF]

Journal of Biomedical Research, 2010
The failure of axons to regenerate is a major obstacle for functional recovery after central nervous system (CNS) injury. Removing extracellular inhibitory molecules results in limited axon regeneration in vivo.
openaire   +4 more sources

AKT-dependent and -independent pathways mediate PTEN deletion-induced CNS axon regeneration

Cell Death and Disease, 2019
Phosphatase and tensin homolog (PTEN) acts as a brake for the phosphatidylinositol 3-kinase–AKT–mTOR complex 1 (mTORC1) pathway, the deletion of which promotes potent central nervous system (CNS) axon regeneration.
Haoliang Huang, Linqing Miao, Liu Yang, Feisi Liang, Qizhao Wang, Zhuang Pei, Yang Sun, Yang Hu   +7 more
semanticscholar   +1 more source