Results 81 to 90 of about 769,118 (313)
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance Functional impairment and poor recovery following central nervous system injury is due to the failure of injured axons to regenerate and rebuild functional connections.
Y. M. Oh +5 more
semanticscholar +1 more source
Imine Crosslinked, Injectable, and Self‐Healing Fucoidan Hydrogel with Immunomodulatory Properties
Advanced Healthcare Materials, EarlyView.This study develops an injectable fucoidan‐based hydrogel with tunable properties for tissue engineering. By oxidizing fucoidan (OFu) to introduce aldehydes, imine crosslinks are formed with amine‐containing polymers, enabling self‐healing, injectability, and long‐term stability (≥28 days). The OFu‐gelatin hydrogel demonstrated biocompatibility, immune‐
Asma Talib Qureshi +3 more
wiley +1 more source
The C. elegans Discoidin Domain Receptor DDR-2 Modulates the Met-like RTK-JNK Signaling Pathway in Axon Regeneration. [PDF]
PLoS Genetics, 2016 The ability of specific neurons to regenerate their axons after injury is governed by cell-intrinsic regeneration pathways. However, the signaling pathways that orchestrate axon regeneration are not well understood.
Naoki Hisamoto +4 more
doaj +1 more source
Neural Regeneration Research, 2019 The peripheral nervous system has an astonishing ability to regenerate following a compression or crush injury; however, the potential for full repair following a transection injury is much less.
X. Dun, D. Parkinson
semanticscholar +1 more source
Advanced Materials, EarlyView.Protein can undergo liquid–liquid phase separation and liquid‐to‐solid transition to form liquid condensates and solid aggregates. These phase transitions can be influenced by post‐translational modifications, mutations, and various environmental factors.
Tianchen Li +3 more
wiley +1 more source
Lin28 Signaling Supports Mammalian PNS and CNS Axon Regeneration
Cell Reports, 2018 Summary: RNA-binding proteins Lin28a/b regulate cellular growth and tissue regeneration. Here, we investigated the role of Lin28 in the control of axon regeneration in postmitotic neurons.
Xue-Wei Wang +9 more
doaj
gACSON software for automated segmentation and morphology analyses of myelinated axons in 3D electron microscopy [PDF]
arXiv, 2021 Background and Objective: Advances in electron microscopy (EM) now allow three-dimensional (3D) imaging of hundreds of micrometers of tissue with nanometer-scale resolution, providing new opportunities to study the ultrastructure of the brain. In this work, we introduce a freely available Matlab-based gACSON software for visualization, segmentation ...
arxiv
Circ-Spidr enhances axon regeneration after peripheral nerve injury
Cell Death and Disease, 2019 Accumulating evidence suggests that circular RNAs (circRNAs) are abundant and play critical roles in the nervous system. However, their functions in axon regeneration after neuronal injury are unclear.
Susu Mao +6 more
semanticscholar +1 more source
Advanced Materials, EarlyView.Carbon‐based piezoelectric materials are systematically categorized based on their structural and functional properties. The mechanisms of stress‐induced charge transfer are elucidated, and their applications are explored across three key domains: piezoelectric catalysis for energy conversion and environmental remediation, piezoelectric biomedical ...
Mude Zhu +3 more
wiley +1 more source
eLife, 2016 Axon injury triggers dramatic changes in gene expression. While transcriptional regulation of injury-induced gene expression is widely studied, less is known about the roles of RNA binding proteins (RBPs) in post-transcriptional regulation during axon ...
Lizhen Chen +8 more
doaj +1 more source