Results 21 to 30 of about 271,555 (310)

Prospective, Observational, Multicenter, Real-World Study of the Efficacy, Safety, and Pattern of Use of the Dexamethasone Intravitreal Implant in Diabetic Macular Edema in France: Short-Term Outcomes of LOUVRE 3

Ophthalmology and Therapy, 2023
Introduction To evaluate real-world efficacy, safety, and treatment patterns with the dexamethasone intravitreal implant (DEX) in diabetic macular edema (DME) in France.
Laurent Kodjikian, Cécile Delcourt, Catherine Creuzot-Garcher, Pascale Massin, John Conrath, Marie-Ève Velard, Thibaut Lassalle, Sybil Pinchinat, Laure Dupont-Benjamin   +8 more
doaj   +1 more source

The SARM1 TIR NADase: Mechanistic Similarities to Bacterial Phage Defense and Toxin-Antitoxin Systems

Frontiers in Immunology, 2021
The Toll/interleukin-1 receptor (TIR) domain is the signature signalling motif of innate immunity, with essential roles in innate immune signalling in bacteria, plants, and animals.
Aaron DiAntonio, Aaron DiAntonio, Jeffrey Milbrandt, Jeffrey Milbrandt, Matthew D. Figley   +4 more
doaj   +1 more source

A mutation in dynein rescues axonal transport defects and extends the life span of ALS mice [PDF]

, 2005
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative condition characterized by motoneuron degeneration and muscle paralysis. Although the precise pathogenesis of ALS remains unclear, mutations in Cu/Zn superoxide dismutase (SOD1) account for
Dairin Kieran, Martin, J, Joanne Martin, Schiavo, G, Giampietro Schiavo (107907), Dick, JRT, Greensmith, L., Joanne Martin (11260388), Bohnert, S, Hafezparast, M., Elizabeth M.C. Fisher, Fisher, EMC, Linda Greensmith, Stephanie Bohnert (16066082), Martin, J., Majid Hafezparast (4461484), Fisher, E.M.C., James R T Dick (16066085), Majid Hafezparast, Greensmith, L, Linda Greensmith (252146), Giampietro Schiavo, Kieran, D., Bohnert, S., Stephanie Bohnert, James R.T. Dick, Dairin Kieran (7953794), Dick, J.R.T., Kieran, D, Hafezparast, M, Schiavo, G., Elizabeth M C Fisher (16062626)   +31 more
core   +1 more source

Axonal damage accumulates in the progressive phase of multiple sclerosis: three year follow up study [PDF]

, 2005
BACKGROUND: Neurofilament phosphoforms (Nf) are principal components of the axoskeleton released during axonal injury. Cerebrospinal fluid (CSF) levels of Nf phosphoforms might be useful surrogate markers for disability in multiple sclerosis (MS), aid in
Polman, C.H., Grant, D., Uitdehaag, B.M.J., Lazeron, R.H., Eikelenboom, M.J., Petzold, A., Thompson, E.J., Keir, G., Giovannoni, G., Lazeron, R.H.C.   +9 more
core   +1 more source

Myelinating satellite oligodendrocytes are integrated in a glial syncytium constraining neuronal high-frequency activity

Nature Communications, 2016
Satellite oligodendrocytes (s-OLs) are characterised by their close proximity to neocortical pyramidal cells. Here, the authors find that s-OLs myelinate axons and activity of host neurons evokes inward K+ currents in s-OLs which may work to modulate ...
Arne Battefeld, Jan Klooster, Maarten H. P. Kole   +2 more
doaj   +1 more source

Charcot-Marie-Tooth Disease Type 1A: Axonal Lesions

Pediatric Neurology Briefs, 2000
The clinical and electrophysiological phenotype in 42 patients with Charcot-Marie-Tooth disease type 1A (CMT1A) were analysed at Wayne State University, Detroit, MI.
J Gordon Millichap
doaj   +1 more source

Diffusion tensor tractography characteristics of axonal injury in concussion/mild traumatic brain injury

Neural Regeneration Research, 2022
The main advantage of diffusion tensor tractography is that it allows the entire neural tract to be evaluated. In addition, configurational analysis of reconstructed neural tracts can indicate abnormalities such as tearing, narrowing, or discontinuations,
Sung Ho Jang, You Sung Seo
doaj   +1 more source

Exploiting device mismatch in neuromorphic VLSI systems to implement axonal delays [PDF]

, 2012
Axonal delays are used in neural computation to implement faithful models of biological neural systems, and in spiking neural networks models to solve computationally demanding tasks. While there is an increasing number of software simulations of spiking
Sadique Sheik, Sheik, S., Sheik, Sadique, Indiveri, G., Giacomo Indiveri, Elisabetta Chicca, Chicca, Elisabetta, Indiveri, Giacomo, Chicca, Elisabetta ; https://orcid.org/   +8 more
core   +1 more source

Stem cell-based therapies combined with nano-biomaterials for nerve regeneration and repair [PDF]

Scripta Medica
Nerve injuries, often resulting from trauma or degenerative diseases, pose significant challenges due to limited regenerative capacity of nervous system.
Mittal Vishnu, Sharma Anjali, Goyal Rajat, Wilson Kashish, Hooda Tanuj, Chopra Shivani, Chopra Hitesh   +6 more
doaj   +1 more source

Ca2+ entry through NaV channels generates submillisecond axonal Ca2+ signaling

eLife, 2020
Calcium ions (Ca2+) are essential for many cellular signaling mechanisms and enter the cytosol mostly through voltage-gated calcium channels. Here, using high-speed Ca2+ imaging up to 20 kHz in the rat layer five pyramidal neuron axon we found that ...
Naomi AK Hanemaaijer, Marko A Popovic, Xante Wilders, Sara Grasman, Oriol Pavón Arocas, Maarten HP Kole   +5 more
doaj   +1 more source