Results 121 to 130 of about 2,309,945 (284)
Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke
Advanced Science, EarlyView.A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...Nitzan Letko Khait, David Xinzheyang Li, Keyi Guo, Hong Cui, Quinton Sirianni, Dhana Abdo, Cindi M. Morshead, Molly S. Shoichet +7 morewiley +1 more sourceCNTN2 Deficiency Disrupts Ascending Auditory Neuroglial Interactions and Redox Homeostasis in Neural Presbycusis
Advanced Science, EarlyView.. ABSTRACT
Neural presbycusis disrupts auditory timing and speech perception, yet its molecular basis remains poorly understood. This study identifies Cntn2 as the Ranvier's nodal molecule significantly downregulated in aged auditory nerves. Cntn2 heterozygous knockout (Cntn2+/−) mice showed elevated auditory brainstem response thresholds and prolonged Penghui Chen, Jingyi Zhu, Sihan Huang, Beibei Xu, Maoli Duan, Jingrong Lv, Jiarui Chen, Jun Yang, Shule Hou +8 morewiley +1 more sourceGHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis
Advanced Science, EarlyView.Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu +24 morewiley +1 more sourceGm26550 Modulates Learning and Memory by Increasing IGF1 mRNA Expression and Stability in Nrf2−/− Mice
Advanced Science, EarlyView.The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...Hongfang Wang, Ziyao Wang, Dongyue Zuo, Zhaowen Su, Bowen Song, Jiamin Gao, Yizhou Zhang, Ruiting Zhao, Linjie Sun, Mengdi Li, Yirui Fan, Dandan Geng, Lei Wang +12 morewiley +1 more sourceFigure 2. Prion inhibits fast axonal transport of mitochondria in primary hippocampal cultured neurons.
, 2017 Figure 2.Emiliano Zamponi (4707478), Hector H. Caicedo (5013422), Helguera, Pablo R., Fiamma A. Buratti (5013431), Buratti, Fiamma A., Lisa M. Jungbauer (2418157), Pigino, Gustavo F., Alfredo Lorenzo (4707481), Bisbal, Mariano, Lorenzo, Alfredo, Scott T. Brady (413946), Morfini, Gerardo A., Gustavo F. Pigino (421118), Yuyu Song (421110), LaDu, Mary J., Song, Yuyu, Zamponi, Emiliano, Cataldi, Gabriel E., Caicedo, Hector H., Brady, Scott T., Mary J. LaDu (4707484), Ma, Jiyan, Gabriel E. Cataldi (5013428), Pablo R. Helguera (4707475), Gerardo A. Morfini (421107), Mariano Bisbal (176625), Jiyan Ma (300432), Jungbauer, Lisa M. +27 morecore +1 more sourceSmart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing
Advanced Science, EarlyView.Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani +6 morewiley +1 more sourceMagnetoelectric Nanoparticle‐Based Wireless Brain–Computer Interface: Underlying Physics and Projected Technology Pathway
Advanced Science, EarlyView.Magnetoelectric nanoparticles (MENPs) enable fully wireless, minutely invasive neuromodulation, and potentially neural recording, by converting magnetic into electric and, conversely, electric into magnetic fields, respectively, at high spatiotemporal resolution.Elric Zhang, Max Shotbolt, Mostafa Abdel‐Mottaleb, Shawnus Chen, Victoria Andre, Jieyuan Tian, Jonathan Shulgach, Max Murphy, Brian Noga, Ping Liang, Darcy Griffin, Douglas Weber, Marta Pardo, Salvador Pane, Sakhrat Khizroev +14 morewiley +1 more sourceEarly Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity
Advanced Science, EarlyView.This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before Altan Rentsendorj, Jean‐Philippe Vit, Alexandre Hutton, Yosef Koronyo, Saba Shahin, Edward Robinson, Ernesto Barron, Anthony Rodriguez, Ousman Jallow, Julia Sheyn, Bhakta Prasad Gaire, Lalita Subedi, Miyah R. Davis, Barathan Gnanabharathi, Alexander V. Ljubimov, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Debra Hawes, Katlin Silm, Keith L. Black, Lon S. Schneider, Alfredo A. Sadun, Jesse G. Meyer, Dieu‐Trang Fuchs, Maya Koronyo‐Hamaoui +25 morewiley +1 more sourceSupplementary Figure 2. PrP Full length (PrP-FL) inhibits fast axonal transport.
, 2017 Supplementary Figure 2.Emiliano Zamponi (4707478), Hector H. Caicedo (5013422), Helguera, Pablo R., Fiamma A. Buratti (5013431), Buratti, Fiamma A., Lisa M. Jungbauer (2418157), Pigino, Gustavo F., Alfredo Lorenzo (4707481), Bisbal, Mariano, Lorenzo, Alfredo, Scott T. Brady (413946), Morfini, Gerardo A., Gustavo F. Pigino (421118), Yuyu Song (421110), LaDu, Mary J., Song, Yuyu, Zamponi, Emiliano, Cataldi, Gabriel E., Caicedo, Hector H., Brady, Scott T., Mary J. LaDu (4707484), Ma, Jiyan, Gabriel E. Cataldi (5013428), Pablo R. Helguera (4707475), Gerardo A. Morfini (421107), Mariano Bisbal (176625), Jiyan Ma (300432), Jungbauer, Lisa M. +27 morecore +1 more source
