Results 1 to 10 of about 6,084 (75)

Predicting the distribution of serotonergic axons: a supercomputing simulation of reflected fractional Brownian motion in a 3D-mouse brain model

open access: yesFrontiers in Computational Neuroscience, 2023
The self-organization of the brain matrix of serotonergic axons (fibers) remains an unsolved problem in neuroscience. The regional densities of this matrix have major implications for neuroplasticity, tissue regeneration, and the understanding of mental ...
Skirmantas Janušonis   +4 more
doaj   +1 more source

Estimation of electric field impact in deep brain stimulation from axon diameter distribution in the human brain [PDF]

open access: yesBiomedical Physics & Engineering Express 2021, 2021
Background: Finite element method (FEM) simulations of the electric field magnitude (EF) are commonly used to estimate the affected tissue surrounding the active contact of deep brain stimulation (DBS) leads. Previous studies have found that DBS starts to noticeably activate axons at approximately 0.2 V/mm, corresponding to activation of 3.4 $\mu$m ...
arxiv   +1 more source

Multiple Copies of microRNA Binding Sites in Long 3′UTR Variants Regulate Axonal Translation

open access: yesCells, 2023
Rapid responses to changes within subcellular compartments of highly polarized cells, such as neuron axons, depend on local translation and post-transcriptional regulation.
Luba Farberov   +7 more
doaj   +1 more source

Loss of highwire Protects Against the Deleterious Effects of Traumatic Brain Injury in Drosophila Melanogaster

open access: yesFrontiers in Neurology, 2020
Traumatic brain injury is a major global cause of death and disability. Axonal injury is a major underlying mechanism of TBI and could represent a major therapeutic target.
Ciaran S. Hill   +8 more
doaj   +1 more source

Collagen‐rich deposit formation in the sciatic nerve after injury and surgical repair: A study of collagen‐producing cells in a rabbit model

open access: yesBrain and Behavior, 2020
Introduction Posttraumatic scarring of peripheral nerves produces unwanted adhesions that block axonal growth. In the context of surgical nerve repair, the organization of the scar tissue adjacent to conduits used to span the gap between the stumps of ...
Jolanta Fertala   +5 more
doaj   +1 more source

Decellularized skeletal muscles display neurotrophic effects in three‐dimensional organotypic cultures

open access: yesStem Cells Translational Medicine, 2020
Skeletal muscle decellularization allows the generation of natural scaffolds that retain the extracellular matrix (ECM) mechanical integrity, biological activity, and three‐dimensional (3D) architecture of the native tissue. Recent reports showed that in
Paolo Raffa   +9 more
doaj   +1 more source

Electron cryo-tomography reveals the subcellular architecture of growing axons in human brain organoids

open access: yeseLife, 2021
During brain development, axons must extend over great distances in a relatively short amount of time. How the subcellular architecture of the growing axon sustains the requirements for such rapid build-up of cellular constituents has remained elusive ...
Patrick C Hoffmann   +6 more
doaj   +1 more source

The Requirement of Sox2 for the Spinal Cord Motor Neuron Development of Zebrafish

open access: yesFrontiers in Molecular Neuroscience, 2020
Sex-determining region Y box 2 (Sox2), expressed in neural tissues, plays an important role as a transcription factor not only in the pluripotency and proliferation of neuronal cells but also in the opposite function of cell differentiation. Nevertheless,
Jie Gong   +12 more
doaj   +1 more source

The Flow of Axonal Information Among Hippocampal Subregions: 1. Feed-Forward and Feedback Network Spatial Dynamics Underpinning Emergent Information Processing

open access: yesFrontiers in Neural Circuits, 2021
The tri-synaptic pathway in the mammalian hippocampus enables cognitive learning and memory. Despite decades of reports on anatomy and physiology, the functional architecture of the hippocampal network remains poorly understood in terms of the dynamics ...
Yash S. Vakilna   +4 more
doaj   +1 more source

Ontogenetic Shifts in the Number of Axons in the Olfactory Tract and Optic Nerve in Two Species of Deep-Sea Grenadier Fish (Gadiformes: Macrouridae: Coryphaenoides)

open access: yesFrontiers in Ecology and Evolution, 2018
Neuroanatomical studies of the peripheral sense organs and brains of deep-sea fishes are particularly useful for predicting their sensory capabilities and ultimately their behavior.
Thomas J. Lisney   +4 more
doaj   +1 more source

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