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Pseudorabies Virus Mutants Lacking US9 Are Defective in Cytoplasmic Assembly and Sorting of Virus Particles into Axons and Not in Axonal Transport [PDF]

Viruses, 2023
Herpes simplex virus (HSV) and varicella zoster virus (VZV) rely on transport of virus particles in neuronal axons to spread from sites of viral latency in sensory ganglia to peripheral tissues then on to other hosts.
Steven Adamou, Adam Vanarsdall, David C. Johnson   +2 more
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Predicting the distribution of serotonergic axons: a supercomputing simulation of reflected fractional Brownian motion in a 3D-mouse brain model

Frontiers in Computational Neuroscience, 2023
The self-organization of the brain matrix of serotonergic axons (fibers) remains an unsolved problem in neuroscience. The regional densities of this matrix have major implications for neuroplasticity, tissue regeneration, and the understanding of mental ...
Skirmantas Janušonis, Justin H. Haiman, Ralf Metzler, Ralf Metzler, Thomas Vojta   +4 more
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Multiple Copies of microRNA Binding Sites in Long 3′UTR Variants Regulate Axonal Translation

Cells, 2023
Rapid responses to changes within subcellular compartments of highly polarized cells, such as neuron axons, depend on local translation and post-transcriptional regulation.
Luba Farberov, Ariel Ionescu, Yazeed Zoabi, Guy Shapira, Amjd Ibraheem, Yosi Azan, Eran Perlson, Noam Shomron   +7 more
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Probing brain tissue microstructure with MRI: principles, challenges, and the role of multidimensional diffusion-relaxation encoding

NeuroImage, 2023
Diffusion MRI uses the random displacement of water molecules to sensitize the signal to brain microstructure and to properties such as the density and shape of cells. Microstructure modeling techniques aim to estimate these properties from acquired data
Björn Lampinen, Filip Szczepankiewicz, Jimmy Lätt, Linda Knutsson, Johan Mårtensson, Isabella M. Björkman-Burtscher, Danielle van Westen, Pia C. Sundgren, Freddy Ståhlberg, Markus Nilsson   +9 more
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Unrestrained growth of correctly oriented microtubules instructs axonal microtubule orientation

eLife, 2022
In many eukaryotic cells, directed molecular transport occurs along microtubules. Within neuronal axons, transport over vast distances particularly relies on uniformly oriented microtubules, whose plus-ends point towards the distal axon tip ...
Maximilian AH Jakobs, Assaf Zemel, Kristian Franze   +2 more
doaj   +1 more source

Collagen‐rich deposit formation in the sciatic nerve after injury and surgical repair: A study of collagen‐producing cells in a rabbit model

Brain and Behavior, 2020
Introduction Posttraumatic scarring of peripheral nerves produces unwanted adhesions that block axonal growth. In the context of surgical nerve repair, the organization of the scar tissue adjacent to conduits used to span the gap between the stumps of ...
Jolanta Fertala, Michael Rivlin, Mark L. Wang, Pedro K. Beredjiklian, Andrzej Steplewski, Andrzej Fertala   +5 more
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Response Selectivity of the Lateral Posterior Nucleus Axons Projecting to the Mouse Primary Visual Cortex

Frontiers in Neural Circuits, 2022
Neurons in the mouse primary visual cortex (V1) exhibit characteristic response selectivity to visual stimuli, such as orientation, direction and spatial frequency selectivity. Since V1 receives thalamic visual inputs from the lateral geniculate nucleus (
Satoru Kondo, Satoru Kondo, Yuko Kiyohara, Kenichi Ohki, Kenichi Ohki, Kenichi Ohki   +5 more
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Interferon inhibits the release of herpes simplex virus-1 from the axons of sensory neurons

mBio, 2023
Herpes simplex virus-1 (HSV-1) has evolved mechanisms to evade the host immune system and limit the antiviral effects induced by interferon (IFN) produced by local epithelial and immune cells.
Kevin Danastas, Gerry Guo, Jessica Merjane, Nathan Hong, Ava Larsen, Monica Miranda-Saksena, Anthony L. Cunningham   +6 more
doaj   +1 more source

Ontogenetic Shifts in the Number of Axons in the Olfactory Tract and Optic Nerve in Two Species of Deep-Sea Grenadier Fish (Gadiformes: Macrouridae: Coryphaenoides)

Frontiers in Ecology and Evolution, 2018
Neuroanatomical studies of the peripheral sense organs and brains of deep-sea fishes are particularly useful for predicting their sensory capabilities and ultimately their behavior.
Thomas J. Lisney, Thomas J. Lisney, Hans-Joachim Wagner, Shaun P. Collin, Shaun P. Collin   +4 more
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Decellularized skeletal muscles display neurotrophic effects in three‐dimensional organotypic cultures

Stem Cells Translational Medicine, 2020
Skeletal muscle decellularization allows the generation of natural scaffolds that retain the extracellular matrix (ECM) mechanical integrity, biological activity, and three‐dimensional (3D) architecture of the native tissue. Recent reports showed that in
Paolo Raffa, Valentina Scattolini, Mattia Francesco Maria Gerli, Silvia Perin, Meihua Cui, Paolo De Coppi, Nicola Elvassore, Paola Caccin, Camilla Luni, Anna Urciuolo   +9 more
doaj   +1 more source