Results 11 to 20 of about 170,375 (242)

Unrestrained growth of correctly oriented microtubules instructs axonal microtubule orientation

eLife, 2022
In many eukaryotic cells, directed molecular transport occurs along microtubules. Within neuronal axons, transport over vast distances particularly relies on uniformly oriented microtubules, whose plus-ends point towards the distal axon tip ...
Maximilian AH Jakobs, Assaf Zemel, Kristian Franze   +2 more
doaj   +1 more source

Response Selectivity of the Lateral Posterior Nucleus Axons Projecting to the Mouse Primary Visual Cortex

Frontiers in Neural Circuits, 2022
Neurons in the mouse primary visual cortex (V1) exhibit characteristic response selectivity to visual stimuli, such as orientation, direction and spatial frequency selectivity. Since V1 receives thalamic visual inputs from the lateral geniculate nucleus (
Satoru Kondo, Satoru Kondo, Yuko Kiyohara, Kenichi Ohki, Kenichi Ohki, Kenichi Ohki   +5 more
doaj   +1 more source

Interferon inhibits the release of herpes simplex virus-1 from the axons of sensory neurons

mBio, 2023
Herpes simplex virus-1 (HSV-1) has evolved mechanisms to evade the host immune system and limit the antiviral effects induced by interferon (IFN) produced by local epithelial and immune cells.
Kevin Danastas, Gerry Guo, Jessica Merjane, Nathan Hong, Ava Larsen, Monica Miranda-Saksena, Anthony L. Cunningham   +6 more
doaj   +1 more source

The role of higher-order thalamus during learning and correct performance in goal-directed behavior

eLife, 2022
The thalamus is a gateway to the cortex. Cortical encoding of complex behavior can therefore only be understood by considering the thalamic processing of sensory and internally generated information.
Danilo La Terra, Ann-Sofie Bjerre, Marius Rosier, Rei Masuda, Tomás J Ryan, Lucy M Palmer   +5 more
doaj   +1 more source

Local Accumulation of Axonal Mitochondria in the Optic Nerve Glial Lamina Precedes Myelination

Frontiers in Neuroanatomy, 2021
Mitochondria are essential for neurons and must be optimally distributed along their axon to fulfill local functions. A high density of mitochondria has been observed in retinal ganglion cell (RGC) axons of an unmyelinated region of the optic nerve ...
Samantha J. Wilkison, Samantha J. Wilkison, Cora L. Bright, Cora L. Bright, Ricardo Vancini, Daniel J. Song, Daniel J. Song, Howard M. Bomze, Howard M. Bomze, Romain Cartoni, Romain Cartoni   +10 more
doaj   +1 more source

Pseudorabies Virus Mutants Lacking US9 Are Defective in Cytoplasmic Assembly and Sorting of Virus Particles into Axons and Not in Axonal Transport

Viruses, 2023
Herpes simplex virus (HSV) and varicella zoster virus (VZV) rely on transport of virus particles in neuronal axons to spread from sites of viral latency in sensory ganglia to peripheral tissues then on to other hosts.
Steven Adamou, Adam Vanarsdall, David C. Johnson   +2 more
doaj   +1 more source

Cytoplasmic cleavage of IMPA1 3′ UTR is necessary for maintaining axon integrity

Cell Reports, 2021
Summary: The 3′ untranslated regions (3′ UTRs) of messenger RNAs (mRNAs) are non-coding sequences involved in many aspects of mRNA metabolism, including intracellular localization and translation.
Catia Andreassi, Raphaëlle Luisier, Hamish Crerar, Marousa Darsinou, Sasja Blokzijl-Franke, Tchern Lenn, Nicholas M. Luscombe, Giovanni Cuda, Marco Gaspari, Adolfo Saiardi, Antonella Riccio   +10 more
doaj   +1 more source

Molecular mechanisms separating two axonal pathways during embryonic development of the avian optic tectum [PDF]

, 1991
During embryonic development of the avian optic tectum, retinal and tectobulbar axons form an orthogonal array of nerve processes. Growing axons of both tracts are transiently very closely apposed to each other. Despite this spatial proximity, axons from
Adler, Alvarado-Mallart, Bixby, Bixby, Bonhoeffer, Bonhoeffer, Boxberg, Bray, Cohen, Edelman, Elsdale, Goldberg, Goldberg, Halfter, Halfter, Halfter, Halfter, Halfter, Halfter, Halfter, Hamburger, Hankin, Harris, Haydon, Kapfhammer, Kapfhammer, Kapfhammer, Katz, Kroger, Kröger, Lagenaur, LaVail, Letourneau, Letourneau, Liesi, Linser, Mattson, McCobb, McLoon, O'Leary, Puelles, Rager, Raper, Rathjen, Rogers, Rosner, Sanes, Silver, Silver, Smalheiser, Thanos, Tomaselli, Vanselow, Walter, Wictorin, Zipser   +55 more
core   +1 more source

Block Face Scanning Electron Microscopy of Fluorescently Labeled Axons Without Using Near Infra-Red Branding

Frontiers in Neuroanatomy, 2018
In this article, we describe the method that allows fluorescently tagged structures such as axons to be targeted for electron microscopy (EM) analysis without the need to convert their labels into electron dense stains, introduce any fiducial marks, or ...
Catherine Maclachlan, Daniela A. Sahlender, Shuichi Hayashi, Zoltán Molnár, Graham Knott   +4 more
doaj   +1 more source

Electron cryo-tomography reveals the subcellular architecture of growing axons in human brain organoids

eLife, 2021
During brain development, axons must extend over great distances in a relatively short amount of time. How the subcellular architecture of the growing axon sustains the requirements for such rapid build-up of cellular constituents has remained elusive ...
Patrick C Hoffmann, Stefano L Giandomenico, Iva Ganeva, Michael R Wozny, Magdalena Sutcliffe, Madeline A Lancaster, Wanda Kukulski   +6 more
doaj   +1 more source