Results 21 to 30 of about 271,417 (354)
eLife, 2021 During brain development, axons must extend over great distances in a relatively short amount of time. How the subcellular architecture of the growing axon sustains the requirements for such rapid build-up of cellular constituents has remained elusive ...
Patrick C Hoffmann +6 more
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Brain and Behavior, 2020 Introduction Posttraumatic scarring of peripheral nerves produces unwanted adhesions that block axonal growth. In the context of surgical nerve repair, the organization of the scar tissue adjacent to conduits used to span the gap between the stumps of ...
Jolanta Fertala +5 more
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Frontiers in Neural Circuits, 2021 The tri-synaptic pathway in the mammalian hippocampus enables cognitive learning and memory. Despite decades of reports on anatomy and physiology, the functional architecture of the hippocampal network remains poorly understood in terms of the dynamics ...
Yash S. Vakilna +4 more
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Stem Cells Translational Medicine, 2020 Skeletal muscle decellularization allows the generation of natural scaffolds that retain the extracellular matrix (ECM) mechanical integrity, biological activity, and three‐dimensional (3D) architecture of the native tissue. Recent reports showed that in
Paolo Raffa +9 more
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Frontiers in Ecology and Evolution, 2018 Neuroanatomical studies of the peripheral sense organs and brains of deep-sea fishes are particularly useful for predicting their sensory capabilities and ultimately their behavior.
Thomas J. Lisney +4 more
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Lmx1b is required at multiple stages to build expansive serotonergic axon architectures
eLife, 2019 Formation of long-range axons occurs over multiple stages of morphological maturation. However, the intrinsic transcriptional mechanisms that temporally control different stages of axon projection development are unknown. Here, we addressed this question
Lauren J Donovan +7 more
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Rapid signaling in distinct dopaminergic axons during locomotion and reward
Nature, 2016 Dopaminergic projection axons from the midbrain to the striatum are crucial for motor control, as their degeneration in Parkinson disease results in profound movement deficits. Paradoxically, most recording methods report rapid phasic dopamine signalling
M. Howe, D. Dombeck
semanticscholar +1 more source
eLife, 2015 In this study, we investigated how microtubule motors organize microtubules in Drosophila neurons. We showed that, during the initial stages of axon outgrowth, microtubules display mixed polarity and minus-end-out microtubules push the tip of the axon ...
Urko del Castillo +3 more
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Oligodendroglia metabolically support axons and contribute to neurodegeneration
Nature, 2012 Oligodendroglia support axon survival and function through mechanisms independent of myelination, and their dysfunction leads to axon degeneration in several diseases. The cause of this degeneration has not been determined, but lack of energy metabolites
Youngjin Lee +12 more
semanticscholar +1 more source
Dynamic m6A modification regulates local translation of mRNA in axons
Nucleic Acids Research, 2017 N 6-methyladenosine (m6A) is a reversible modification in mRNA and has been shown to regulate processing, translation and decay of mRNA. However, the roles of m6A modification in neuronal development are still not known.
Jun Yu +7 more
semanticscholar +1 more source