Results 41 to 50 of about 431,675 (382)
Nature Communications, 2015 The myelin sheath on vertebrate axons is critical for neural impulse transmission, but whether electrically active axons are preferentially myelinated by glial cells, and if so, whether axo-glial synapses are involved, are long-standing questions of ...
H. Wake +5 more
semanticscholar +1 more source
Unrestrained growth of correctly oriented microtubules instructs axonal microtubule orientation
eLife, 2022 In many eukaryotic cells, directed molecular transport occurs along microtubules. Within neuronal axons, transport over vast distances particularly relies on uniformly oriented microtubules, whose plus-ends point towards the distal axon tip ...
Maximilian AH Jakobs +2 more
doaj +1 more source
Journal of Cell Biology, 2014 The Parkinson’s disease–associated proteins PINK1 and Parkin mediate local mitophagy of dysfunctional mitochondria in distal neuronal axons, abrogating the need for retrograde organelle transport and ensuring rapid neuroprotection.
Ghazaleh Ashrafi +3 more
semanticscholar +1 more source
Local Accumulation of Axonal Mitochondria in the Optic Nerve Glial Lamina Precedes Myelination
Frontiers in Neuroanatomy, 2021 Mitochondria are essential for neurons and must be optimally distributed along their axon to fulfill local functions. A high density of mitochondria has been observed in retinal ganglion cell (RGC) axons of an unmyelinated region of the optic nerve ...
Samantha J. Wilkison +10 more
doaj +1 more source
A chloride channel in rat and human axons [PDF]
, 1991 Current recordings from single chloride channels were obtained from excised and cell-attached patches of rat and human axons. In rat axons the channels showed an outwardly rectifying current-voltage relationship with a slope conductance of 33 pS at ...
Baker +19 more
core +1 more source
Cortical AAV-CNTF gene therapy combined with intraspinal mesenchymal precursor cell transplantation promotes functional and morphological outcomes after spinal cord injury in adult rats [PDF]
, 2018 Ciliary neurotrophic factor (CNTF) promotes survival and enhances long-distance regeneration of injured axons in parts of the adult CNS. Here we tested whether CNTF gene therapy targeting corticospinal neurons (CSN) in motor-related regions of the ...
Akinpelu, Emmanuel A +14 more
core +3 more sources
The Genetics of Axonal Transport and Axonal Transport Disorders
PLoS Genetics, 2006 Neurons are specialized cells with a complex architecture that includes elaborate dendritic branches and a long, narrow axon that extends from the cell body to the synaptic terminal. The organized transport of essential biological materials throughout the neuron is required to support its growth, function, and viability.
Lawrence S.B. Goldstein, Jason E. Duncan
openaire +5 more sources
Human umbilical cord mesenchymal stem cells promote peripheral nerve repair via paracrine mechanisms
Neural Regeneration Research, 2015 Human umbilical cord-derived mesenchymal stem cells (hUCMSCs) represent a promising young-state stem cell source for cell-based therapy. hUCMSC transplantation into the transected sciatic nerve promotes axonal regeneration and functional recovery.
Zhi-yuan Guo +4 more
doaj +1 more source
Interferon inhibits the release of herpes simplex virus-1 from the axons of sensory neurons
mBio, 2023 Herpes simplex virus-1 (HSV-1) has evolved mechanisms to evade the host immune system and limit the antiviral effects induced by interferon (IFN) produced by local epithelial and immune cells.
Kevin Danastas +6 more
doaj +1 more source
Extent and mechanism of sealing in transected giant axons of squid and earthworms [PDF]
, 1994 Transected axons are often assumed to seal at their cut ends by the formation of continuous membrane barriers that allow for the restoration of function in the axonal stumps.
Ballinger, Martis L. +3 more
core +1 more source