Results 41 to 50 of about 30,406 (272)
The role of higher-order thalamus during learning and correct performance in goal-directed behavior
eLife, 2022 The thalamus is a gateway to the cortex. Cortical encoding of complex behavior can therefore only be understood by considering the thalamic processing of sensory and internally generated information.
Danilo La Terra +5 more
doaj +1 more source
NeuroImage, 2023 Diffusion MRI uses the random displacement of water molecules to sensitize the signal to brain microstructure and to properties such as the density and shape of cells. Microstructure modeling techniques aim to estimate these properties from acquired data
Björn Lampinen +9 more
doaj
eLife, 2019 Cortical collapse factors affect microtubule (MT) dynamics at the plasma membrane. They play important roles in neurons, as suggested by inhibition of axon growth and regeneration through the ARF activator Efa6 in C.
Yue Qu +11 more
doaj +1 more source
Modeling tau transport in the axon initial segment [PDF]
Mathematical Biosciences, vol. 329, article # 108468, 2020, 2020 By assuming that tau protein can be in seven kinetic states, we developed a model of tau protein transport in the axon and in the axon initial segment (AIS). Two separate sets of kinetic constants were determined, one in the axon and the other in the AIS.
arxiv +1 more source
Intra-axonal mechanisms driving axon regeneration
Brain Research, 2020 Traumatic injury to the peripheral and central nervous systems very often causes axotomy, where an axon loses connections with its target resulting in loss of function. The axon segments distal to the injury site lose connection with the cell body and degenerate.
Terika P. Smith +3 more
openaire +3 more sources
Uncovering Discrete Synaptic Proteomes to Understand Neurological Disorders
Proteomes, 2018 The mammalian nervous system is an immensely heterogeneous organ composed of a diverse collection of neuronal types that interconnect in complex patterns.
Yi-Zhi Wang, Jeffrey N. Savas
doaj +1 more source
A Fractional Viscoelastic Model Of The Axon In Brain White Matter [PDF]
arXiv, 2023 Traumatic axonal injury occurs when loads experienced on the tissue-scale are transferred to the individual axons. Mechanical characterization of axon deformation especially under dynamic loads however is extremely difficult owing to their viscoelastic properties.
arxiv
Resveratrol promotes axonal regeneration via PI3K/Akt pathway in rats after intracerebral hemorrhage
Di-san junyi daxue xuebao, 2019 Objective To investigate the mechanism by which resveratrol (RES) promotes axonal regeneration in rats after intracerebral hemorrhage (ICH) and explore the role of the PI3K/Akt pathway that regulates the AMPKα pathway.
WANG Guanyu +4 more
doaj +1 more source
Graphene promotes axon elongation through local stall of Nerve Growth Factor signaling endosomes [PDF]
, 2020 Several works reported increased differentiation of neuronal cells grown on graphene; however, the molecular mechanism driving axon elongation on this material has remained elusive. Here, we study the axonal transport of nerve growth factor (NGF), the neurotrophin supporting development of peripheral neurons, as a key player in the time course of ...
arxiv +1 more source
gACSON software for automated segmentation and morphology analyses of myelinated axons in 3D electron microscopy [PDF]
arXiv, 2021 Background and Objective: Advances in electron microscopy (EM) now allow three-dimensional (3D) imaging of hundreds of micrometers of tissue with nanometer-scale resolution, providing new opportunities to study the ultrastructure of the brain. In this work, we introduce a freely available Matlab-based gACSON software for visualization, segmentation ...
arxiv