Results 51 to 60 of about 170,375 (242)
The Associations Between Chronic Active Lesions and White Matter Disease: A 7 Tesla Imaging Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background The relationship between paramagnetic rim lesions (PRLs) and surrounding normally appearing white matter (NAWM) disease, potentially contributory to the associations seen between PRLs and clinical impairment, is underexplored. Objectives To assess whether PRLs correlate with a greater degree of NAWM injury in early MS.
Ellie McCluey +17 more
wiley +1 more source
The Drosophila immunoglobulin gene turtle encodes guidance molecules involved in axon pathfinding [PDF]
, 2009 Background: Neuronal growth cones follow specific pathways over long distances in order to reach their appropriate targets. Research over the past 15 years has yielded a large body of information concerning the molecules that regulate this process.
Al-Anzi, Bader, Wyman, Robert J.
core +4 more sources
Central Dysmyelination in SSADH‐Deficient Humans and Mice
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives Succinic semialdehyde dehydrogenase deficiency (SSADHD) is an inherited metabolic disorder characterized by an accumulation of γ‐aminobutyric (GABA). In addition to its synaptic role as an inhibitory neurotransmitter, GABA also plays an important role in myelination.
Itay Tokatly Latzer +11 more
wiley +1 more source
Atypical Extracellular Action Potentials from Posteromedial Hypothalamus in Anesthetized Humans
Frontiers in Bioscience-Landmark, 2022 Background: We obtained microelectrode recordings from four patients with intractable aggressivity who underwent surgery at posteromedial hypothalamus under general anaesthesia.
Jesús Pastor +2 more
doaj +1 more source
GABA increases electrical excitability in a subset of human unmyelinated peripheral axons [PDF]
, 2010 A proportion of small diameter primary sensory neurones innervating human skin are chemosensitive. They respond in a receptor dependent manner to chemical mediators of inflammation as well as naturally occurring algogens, thermogens and pruritogens.
Carr, Richard W +3 more
core +4 more sources
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Prognostication of disease course and prediction of treatment response in multiple sclerosis is an unmet need. We compared the performance of serum neurofilament light chain Z scores (age‐ and BMI‐adjusted) with absolute concentrations for the prediction of response to disease‐modifying therapy.
Maximilian Einsiedler +43 more
wiley +1 more source
Lmx1b is required at multiple stages to build expansive serotonergic axon architectures
eLife, 2019 Formation of long-range axons occurs over multiple stages of morphological maturation. However, the intrinsic transcriptional mechanisms that temporally control different stages of axon projection development are unknown. Here, we addressed this question
Lauren J Donovan +7 more
doaj +1 more source
Spinal cord injury regulates circular RNA expression in axons
Frontiers in Molecular Neuroscience, 2023 IntroductionNeurons transport mRNA and translational machinery to axons for local translation. After spinal cord injury (SCI), de novo translation is assumed to enable neurorepair. Knowledge of the identity of axonal mRNAs that participate in neurorepair
Mustafa M. Siddiq +25 more
doaj +1 more source
Loss-of-function analysis of EphA receptors in retinotectal mapping [PDF]
, 2004 Peer reviewedPublisher ...
DeChiara, Thomas M. +7 more
core +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives Repetitive transcranial magnetic stimulation (rTMS) is a non‐invasive brain stimulation strategy with a demonstrated potential to reinforce the residual pathways after a spinal cord injury (SCI). A preclinically tested high‐frequency (15 Hz) rTMS (15 Hz rTMS) protocol was shown to induce corticospinal tract axon regeneration growth ...
Nabila Brihmat +8 more
wiley +1 more source