Results 61 to 70 of about 448,604 (375)

Isolation, characterization, and substrate properties of the external limiting membrane from the avian embryonic optic tectum [PDF]

, 1990
The external limiting membrane of the avian embryonic optic tectum is isolated by mechanically separating the neuronal mesencephalon from the overlying mesenchymal tissue.
Adler, Anderson, Avnur, Bodick, Bonhoeffer, Bovolenta, Condic, Davis, DeLong, Dodd, Dow, Dziadek, Dziadek, Easter, Fallon, Goldberg, Halfter, Halfter, Halfter, Halfter, Halfter, Hantaz-Ambroise, Harris, Hinds, Holley, Holt, Kanwar, Kuffler, Kuwada, Letourneau, Manthorpe, Matsusaka, Nakamura, Nardi, Newgreen, Newgreen, Nordlander, Patterson, Puelles, Rager, Reynolds, Roberts, Rogers, Rösner, Rösner, Sanes, Scherer, Schittny, Silver, Singer, Thanos, Thanos, Thanos, Timpl, Timpl, Vanselow, Walter, Walter, Williams   +58 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

GABA increases electrical excitability in a subset of human unmyelinated peripheral axons [PDF]

, 2010
A proportion of small diameter primary sensory neurones innervating human skin are chemosensitive. They respond in a receptor dependent manner to chemical mediators of inflammation as well as naturally occurring algogens, thermogens and pruritogens.
Carr, Richard W, Fleckenstein, Johannes, Grafe, Peter, Sittl, Ruth   +3 more
core   +4 more sources

Molecular determinants of signal transduction in tropomyosin receptor kinases

FEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Fluorescent identification of axons, dendrites and soma of neuronal retinal ganglion cells with a genetic marker as a tool for facilitating the study of neurodegeneration

FASEB BioAdvances
This study characterizes a fluorescent Slc17a6‐tdTomato neuronal reporter mouse line with strong labeling of axons throughout the optic nerve, of retinal ganglion cell (RGC) soma in the ganglion cell layer (GCL), and of RGC dendrites in the inner ...
Puttipong Sripinun, Wennan Lu, Sergei Nikonov, Suhani Patel, Sarah Hennessy, Tianyuan Yao, Qi N. Cui, Brent A. Bell, Claire H. Mitchell   +8 more
doaj   +1 more source

Polybrominated diphenyl ethers perturb axonal growth and actin distribution

Bibechana, 2018
We investigated toxicological effects of two of the most common polybrominated diphenyl ether (PBDE) flame retardants, BDE-47 and BDE-209, in model PC12 cell line under two environmentally relevant exposure conditions:  long term exposure to microgram ...
Bhanu B Neupane, Tao Jin, Zhen Gu, Frances S Ligler, Gufeng Wang   +4 more
doaj   +1 more source

Differential subcellular recruitment of monoacylglycerol lipase generates spatial specificity of 2-arachidonoyl glycerol signaling during axonal pathfinding [PDF]

, 2010
Peer reviewedPublisher ...
Barabas, Klaudia, Cameron, Gary, Harkany, Tibor, Keimpema, Erik, Mackie, Ken, Morozov, Yury M, Torii, Masaaki, Tortoriello, Giuseppe, Watanabe, Masahiko, Yanagawa, Yuchio   +9 more
core   +1 more source

Short Hairpin RNA against PTEN Enhances Regenerative Growth of Corticospinal Tract Axons after Spinal Cord Injury

Journal of Neuroscience, 2013
Developing approaches to promote the regeneration of descending supraspinal axons represents an ideal strategy for rebuilding neuronal circuits to improve functional recovery after spinal cord injury (SCI).
Katherine Zukor, Stéphane Belin, Chen Wang, Nadia Keelan, Xuhua Wang, Zhigang He   +5 more
semanticscholar   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source