Fluorescent Azasteroids through Ultrasound Assisted Cycloaddition Reactions [PDF]
Molecules, 2021 We report here the synthesis and optical spectral properties of several new azasteroid derivatives. The formation of these compounds was explained based on the most probable mechanism.
Costel Moldoveanu +2 more
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Pharmacologic properties and inhibitory activity of 6-azasteroids against Mycobacterium leprae in vivo and in vitro [PDF]
Microbiology SpectrumAlthough the current multidrug therapy (MDT) for leprosy is very successful, the long treatment duration and the emergence of antibiotic-resistant strains demand for new alternative drugs.
Thabatta L. S. A. Rosa +13 more
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A Chemoproteomic Approach to Elucidate the Mechanism of Action of 6-Azasteroids with Unique Activity in Mycobacteria. [PDF]
ACS Infect Dis, 2023 By illuminating key 6-azasteroid–protein interactions in both Mycobacterium tuberculosis (Mtb) and the closely related model organism Mycobacterium marinum (Mm), we sought to improve the antimycobacterial potency of 6-azasteroids and further our ...
Werman JM +4 more
europepmc +2 more sources
Novel 4-Azapregnene Derivatives as Potential Anticancer Agents: Synthesis, Antiproliferative Activity and Molecular Docking Studies [PDF]
Molecules, 2022 A series of novel 21E-arylidene-4-azapregn-5-ene steroids has been successfully designed, synthesized and structurally characterized, and their antiproliferative activity was evaluated in four different cell lines.
Vanessa Brito +4 more
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Inhibition of Phytosterol Biosynthesis by Azasterols [PDF]
Molecules, 2020 Inhibitors of enzymes in essential cellular pathways are potent probes to decipher intricate physiological functions of biomolecules. The analysis of Arabidopsis thaliana sterol profiles upon treatment with a series of azasterols reveals a specific in ...
Sylvain Darnet +5 more
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19-nor-10-azasteroids, a new class of steroid 5 alpha-reductase inhibitors. 2. X-ray structure, molecular modeling, conformational analysis of 19-nor-10-azasteroids and comparison with 4-azasteroids and 6-azasteroids. [PDF]
Journal of Medicinal Chemistry, 1997 19-Nor-10-azasteroids are a new class of 5 alpha-reductase inhibitors whose activity depends on the presence of the bridgehead N-10 atom conjugated with the 4-en-3-one moiety in the A ring. The X-ray structure of 19-nor-10-azasteroid 1 has been determined and it is compared with the X-ray structure of testosterone. A complete conformational analysis of
A. Guarna +6 more
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5-alpha-reductase type I (SRD5A1) is up-regulated in non-small cell lung cancer but does not impact proliferation, cell cycle distribution or apoptosis [PDF]
Cancer Cell International, 2012 Background Non-small cell lung cancer (NSCLC) is one of the most frequent malignancies and has a high mortality rate due to late detection and lack of efficient treatments.
Kapp Friedrich G +4 more
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The 5 alpha-reductase isozyme family: a review of basic biology and their role in human diseases. [PDF]
Adv Urol, 2012 Despite the discovery of 5 alpha‐reduction as an enzymatic step in steroid metabolism in 1951, and the discovery that dihydrotestosterone is more potent than testosterone in 1968, the significance of 5 alpha‐reduced steroids in human diseases was not appreciated until the discovery of 5 alpha‐reductase type 2 deficiency in 1974. Affected males are born
Azzouni F, Godoy A, Li Y, Mohler J.
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Inhibition of the M. tuberculosis 3β-hydroxysteroid dehydrogenase by azasteroids. [PDF]
Bioorg Med Chem Lett, 2011 Thomas ST, Yang X, Sampson NS.
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Indian Journal of Entomology, 2022 Effect of two azasteroids, 25-azacholestane and 25-azacoprostane was studied on growth and development of an economically important phytophagous pest, Helicoverpa armigera (Hubner) causing extensive damage to crops like cotton, pigeon pea, chickpea and ...
Rita Rath +3 more
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