Results 51 to 60 of about 6,873 (149)
The synthesis of functionalized azetidines from azetines is poorly explored. Here, we report the safe and sustainable continuous flow hydrogenation of 2-azetines using ethyl acetate and CPME as environmentally responsible solvents.
Elena Graziano +6 more
doaj +1 more source
Effect of C5-Methylation of Cytosine on the UV-Induced Reactivity of Duplex DNA: Conformational and Electronic Factors [PDF]
International audienceC5-methylation of cytosines is strongly correlated with UV-induced mutations detected in skin cancers. Mutational hot-spots appearing at TCG sites are due to the formation of pyrimidine cyclobutane dimers (CPDs).
Banyasz, Akos +6 more
core +3 more sources
Cobalt-Catalyzed (Hetero)arylation of Saturated Cyclic Amines with Grignard Reagents
(Hetero)aryl substituted saturated cyclic amines are ubiquitous scaffolds in biologically active molecules. Metal-catalyzed cross-couplings between halogeno N-heterocycles and organometallic species are efficient and modular reactions to access these ...
Baptiste Barré +3 more
doaj +1 more source
A convenient and efficient synthesis of novel achiral and chiral heterocyclic amino acid-like building blocks was developed. Regioisomeric methyl 5-(N-Boc-cycloaminyl)-1,2-oxazole-4-carboxylates were prepared by the reaction of β-enamino ketoesters ...
Jolita Bruzgulienė +9 more
doaj +1 more source
(4+2)-cycloaddition of nitroalkenes with ynamines; formation of a 4H-1,2-oxazine 2-oxide derivative [PDF]
The formation of a thermally unstable (4+2)-cycloadduct, a 4H-1,2-oxazine 2-oxide derivative ( ), from the reaction of 1-nitrocyclopentene with 1-phenyl-2-(1-pyrrolidinyl)acetylene has been proven by the structure elucidation of isoxazole derivative ...
Pennings, M.L.M., Reinhoudt, D.N.
core +2 more sources
A cobalt‐salen catalysed hydration of olefins with water is reported, resulting in Markovnikov alcohol products. The reaction proceeds rapidly under mild conditions and exhibits excellent functional group tolerance, supporting a wide range of styrenyl and non‐activated alkenes.
David G. Groves +3 more
wiley +1 more source
Photocatalyzed Ring Expansion of α‐Ketosulfonylaziridines: Ready Access to δ‐Sultams
A novel radical–polar crossover (RPC) photoredox‐catalyzed reaction for the synthesis of δ‐sultams from N‐sulfonyl α‐ketoaziridines through a controlled ring opening–expansion process is presented. This method allows the easy access to sultams with an unprecedented substitution pattern in up to 85% yield and 2:1 d.r., and highlights the potential of ...
Marco M. Mastandrea +7 more
wiley +2 more sources
Orderly arranged NLO materials on exfoliated layeredtemplates based on dendrons with alternating moietiesat the periphery† [PDF]
Nonlinear optical dendrons with alternating terminal groups of the stearyl group (C18) and chromophorewere prepared through a convergent approach. These chromophore-containing dendrons were used asthe intercalating agents for montmorillonite via an ion ...
Jiang-Jen Lin +8 more
core +1 more source
18F‐Radiopharmaceutical Diversification Enabled by Deaminative Cross‐Electrophile Couplings
A general Ni‐mediated (C)sp2–(C)sp3 cross‐coupling expedites access to 18F‐radiopharmaceuticals, essential for positron emission tomography imaging and drug discovery. This late‐stage diversification approach was implemented across three user‐friendly automated protocols affording 18F‐radiotracers in sufficient quantities for imaging.
Isabella F. Ogilvy +13 more
wiley +2 more sources
N-Benzyl-3,5-dideoxy-3,5-imino-1,2-O-isopropylidene-β-l-lyxofuranose
X-ray crystallography confirmed the formation, structure and relative stereochemistry of the title compound, C15H19NO3, which contains a sterically congested four-membered azetidine ring system.
David S. Edgeley +5 more
doaj +1 more source

