Results 101 to 110 of about 29,405 (265)

Dual‐Anchored Clickable Peptide via SPAAC for Gelatinase‐Responsive Antibacterial and Osteogenic Functions on Titanium Implants

Advanced Science, EarlyView.
To address the infection‐associated orthopedic implant failures, this study presents a gelatinase‐responsive antibacterial titanium implant (Ti‐Dual) featuring a dual‐anchored fusion peptide containing antibacterial (HHC36) and osteogenic (RGD) domains connected by a cleavable GPLGV linker.
Ru Zhong, Hang Zhou, Chenyang Ye, Lei Chu, Lin Wang, Yingjun Wang   +5 more
wiley   +1 more source

Macrocyclic Molecular Glues for the 14‐3‐3/ChREBP Interaction: Affinity and Cooperativity in an Inverse Relationship

Angewandte Chemie, EarlyView.
Macrocycles are effective molecular glues to stabilize the 14‐3‐3/ChREBP interaction. Linker length modulation uncovered an inverse correlation between the macrocycle binding affinity to 14‐3‐3 and its cooperativity in 14‐3‐3/ChREBP stabilization.
Marloes A. M. Pennings, Merel A. W. van den Bosch, Ansgar Oberheide, Carlo J. A. Verhoef, Christian Ottmann, Albert J. Markvoort, Galen P. Miley, Luc Brunsveld   +7 more
wiley   +2 more sources

Site-Specific Bioconjugation of a Murine Dihydrofolate Reductase Enzyme by Copper(I)-Catalyzed Azide-Alkyne Cycloaddition with Retained Activity [PDF]

, 2014
Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) is an efficient reaction linking an azido and an alkynyl group in the presence of copper catalyst. Incorporation of a non-natural amino acid (NAA) containing either an azido or an alkynyl group into a ...
A Takasu, AA Kislukhin, Akinori Takasu, AR Goerke, BC Bundy, C Albayrak, C Besanceney-Webler, CH Kim, CW Tornoe, D Banerjee, D Schneider, DB Johnson, DD Young, E Basle, E Lallana, E Steen Redeker, EH Christen, F Rusmini, I Kwon, I Kwon, Inchan Kwon, J Easterbrook, J Liu, JC Anderson, JL Brennan, K Hernandez, K Sivakumar, KE Beatty, KG Patel, L Wang, M Sisido, MH Seo, MP Gillmeister, MR Levengood, MS Hershfield, N Aissaoui, N Budisa, N Soundrarajan, NF Steinmetz, NJ Agard, NW Nairn, PJ Thornalley, Q Wang, S Ahmad, S Schoffelen, S Schoffelen, S Zheng, SE Averick, SI Lim, SI Presolski, Spencer J. Williams, Sung In Lim, SW Santoro, SY McLoughlin, T Hessa, TR Chan, V Cody, V Cody, V Hong, V Shah, VV Rostovtsev, WF Busby Jr, XT Zheng, Yong Hwan Kim, Yukina Mizuta   +64 more
core   +4 more sources

Antibody‐Empowered Nanomedicine for Precise Biomedical Applications

Advanced Science, EarlyView.
This review explores strategies for functionalizing nanoparticles with antibodies to construct antibody‐empowered nanomedicine. It discusses the classification of these nanomedicines based on antibody structure, with a specific focus on their biomedical applications in diagnostics, bioimaging, and therapeutics for various diseases.
Chen Chen, Xinglin Chen, Zhenhao Gao, Meng Sun, Yaozong Yu, Fang Lv, Qiujun Wang, Jinfeng Zhang   +7 more
wiley   +1 more source

Programmable Nanoscale Motion via Molecular Patterning on DNA Origami

Angewandte Chemie, EarlyView.
DNA origami nanorods enable precise urease placement with tunable coverage and asymmetry, revealing that propulsion depends on a balance of catalytic loading and geometry. Maximum speed occurs at ∼25% end‐coverage and declines as enzyme distribution becomes more symmetrical.
Lars Paffen, Maurik Engelbert van Bevervoorde, Andoni Rodriguez‐Abetxuko, Loai Abdelmohsen, Remco van der Hofstad, Jan C.M. van Hest, Tania Patiño Padial   +6 more
wiley   +2 more sources

Exploring structural dynamics of a membrane protein by combining bioorthogonal chemistry and cysteine mutagenesis

eLife, 2019
The functional mechanisms of membrane proteins are extensively investigated with cysteine mutagenesis. To complement cysteine-based approaches, we engineered a membrane protein with thiol-independent crosslinkable groups using azidohomoalanine (AHA), a ...
Kanchan Gupta, Gilman ES Toombes, Kenton J Swartz   +2 more
doaj   +1 more source

N‐Heterocyclic Imine‐Supported Bimetallic Cu(II) Catalyst for Azide‐Alkyne Cycloaddition: Solvent‐free, Reductant‐free, ppm‐level Catalysis to Access 1,4‐Disubstituted Triazoles [PDF]

, 2023
Shanmugam Revathi, Tapas Ghatak
openalex   +1 more source

Expanding the Chemical Space of Cyclic Polyphthalaldehyde via Post‐Functionalization

Advanced Science, EarlyView.
In this work, we developed a post‐functionalization approach to achieve water‐soluble cyclic polyphthalaldehyde (cPPA) polymers via click chemistry. ABSTRACT Cyclic polyphthalaldehydes (cPPAs) are hydrophobic cyclic polymers with stimuli‐responsive depolymerization property. The introduction of hydrophilic functionalities to cPPAs is challenging due to
Liting He, Haiyan Zhou, Qiushi Chen, Xing Guo, Han Liu, Xuechen Li   +5 more
wiley   +1 more source

Relative Rates of Metal-Free Azide-Alkyne Cycloadditions: Tunability over 3 Orders of Magnitude. [PDF]

, 2019
The thermal (3 + 2) dipolar azide-alkyne cycloaddition, proceeding without copper or strained alkynes, is an underutilized ligation with potential applications in materials, bioorganic, and synthetic chemistry.
Braslau, Rebecca, Kitos Vasconcelos, Ana Paula, Li, Longbo, Raskatov, Jevgenij A, Sae-Jew, Jirapon, Skelly, Patrick W, Tasnim, Jerin   +6 more
core  

Chemoselective sequential click ligations directed by enhanced reactivity of an aromatic ynamine [PDF]

, 2016
Aromatic ynamines or N-alkynylheteroarenes are highly reactive alkyne components in Cu-catalyzed Huisgen [3 +2] cycloaddition (“click”) reactions. This enhanced reactivity enables the chemoselective formation of 1,4-triazoles using the representative ...
Burley, Glenn A., Hatit, Marine Z. C., Humphreys, Luke D., McLean, Liam A., Sadler, Joanna C., Seath, Ciaran P., Watson, Allan J. B., Whitehurst, Benjamin C., Young, Robert J.   +8 more
core   +1 more source