Results 61 to 70 of about 29,405 (265)

Acid-Labile Traceless Click Linker for Protein Transduction [PDF]

, 2012
Intracellular delivery of active proteins presents an interesting approach in research and therapy. We created a protein transduction shuttle based on a new traceless click linker that combines the advantages of click reactions with implementation of ...
Bachelder E. M., Dohmen C., Engin K., Ernst Wagner, Frohlich T., Kevin Maier, Lee Y., Meyer M., Meyer M., Meyer M., Miyata K., Murphy R. F., Murthy N., Nieto M. A., Rozema D. B., Rozema D. B., Saxon E., Schaffert D., Vallee M. R., Wagner E., Wagner E., Yu H.   +21 more
core   +1 more source

Color Routing and Beam Steering of Single‐Molecule Emission with a Spherical Silicon Nanoantenna

Advanced Functional Materials, EarlyView.
We experimentally demonstrate broadband directional emission from single molecules using a single spherical silicon nanoparticle assembled via DNA origami. By varying nanoparticle (NP) size and emitter position, we achieve unidirectional emission, beam steering, and color routing at the nanoscale, revealing modal interference as the underlying ...
María Sanz‐Paz, Nicole Siegel, Guillermo Serrera, Javier González‐Colsa, Fangjia Zhu, Karol Kołątaj, Minoru Fujii, Hiroshi Sugimoto, Pablo Albella, Guillermo P. Acuna   +9 more
wiley   +1 more source

Synthesis of triazolo- and tetrazolo-fused 1,4-benzodiazepines via one-pot Ugi–azide and Cu-free click reactions

Beilstein Journal of Organic Chemistry
A one-pot Ugi–azide reaction followed by intramolecular Cu-free azide–alkyne cycloaddition generates a polycyclic scaffold 7 bearing polycyclic triazole, tetrazole, and benzodiazepine rings.
Xiaoming Ma, Zijie Gao, Jiawei Niu, Wentao Shao, Shenghu Yan, Sai Zhang, Wei Zhang   +6 more
doaj   +1 more source

Multiscale Invasion Assay for Probing Macrophage Response to Gram-Negative Bacteria

Frontiers in Chemistry, 2022
The immune system is a complex network of various cellular components that must differentiate between pathogenic bacteria and the commensal bacteria of the human microbiome, where misrecognition is linked to inflammatory disorders. Fragments of bacterial
Kimberly A. Wodzanowski, Jeffrey L. Caplan, Jeffrey L. Caplan, April M. Kloxin, April M. Kloxin, Catherine L. Grimes, Catherine L. Grimes   +6 more
doaj   +1 more source

Increased Anti‐Psoriatic Effect of Anti‐Inflammatory Dendrimers Using Fluid Catanionic Vesicle‐Based Topical Formulations

Advanced Healthcare Materials, EarlyView.
Next‐Generation Psoriasis Therapy – With advanced dendrimer‐based formulations, this study paves the way for highly effective, skin‐permeable treatments. Encapsulated in fluid catanionic vesicles, IMD‐006 and its analogues show promising anti‐psoriatic effects offering a targeted, non‐invasive approach to managing chronic skin inflammation.
Ranime Jebbawi, Abdelouahd Oukhrib, Emily Clement, Hélène Labie, Stéphanie Cassel, Séverine Fruchon, Anne‐Marie Caminade, Michel Simon, Rémy Poupot, Cédric‐Olivier Turrin, Muriel Blanzat   +10 more
wiley   +1 more source

New 1,2,3-Triazoles from (R)-Carvone: Synthesis, DFT Mechanistic Study and In Vitro Cytotoxic Evaluation

Molecules, 2022
Aseries of novel 1,4-disubstituted 1,2,3-triazoles were synthesized from an (R)-carvone terminal alkyne derivative via a Cu (I)-catalyzed azide–alkyne cycloaddition reaction using CuSO4,5H2O as the copper (II) source and sodium ascorbate as a reducing ...
Ali Oubella, Abdoullah Bimoussa, Abdellah N’ait Oussidi, Mourad Fawzi, Aziz Auhmani, Hamid Morjani, Abdelkhalek Riahi, M’hamed Esseffar, Carol Parish, Moulay Youssef Ait Itto   +9 more
doaj   +1 more source

“One-pot” dispersion ATRP and alkyne-azide Huisgen’s 1,3-dipolar cycloaddition in supercritical carbon dioxide: towards the formation of functional microspheres [PDF]

, 2010
Functional polymers were successfully prepared in scCO2 by combining alkyne-azide 1,3-dipolar Huisgen’s cycloaddition and dispersion ATRP in a “one pot” process using new perfluorinated polymeric amino-based ligands that had a dual role, i.e.
Calberg, Cédric, Detrembleur, Christophe, Grignard, Bruno, Jérôme, Christine   +3 more
core   +1 more source

Delivery of Multifunctional Microspheres via Intravesical Instillation for Bladder Carcinoma: Therapeutic Potential and Mechanistic Insights

Advanced Healthcare Materials, EarlyView.
PCTM microspheres were successfully synthesized using microfluidic and click chemistry techniques.In Vivo and in vitro experiments have shown that PCTM microspheres have obvious targeting, adhesion, membrane penetration and anti‐tumor properties for bladder tumors.The antitumor mechanism of PCTM microspheres is to indirectly induce S‐stage blockage of ...
Zhaoxiang Lu, Wentie Yang, Youzhi Hong, Yusen Qiao, Chaozhao Liang   +4 more
wiley   +1 more source

Click Chemistry-Inspired Synthesis and Photophysical Studies of Calix[4]arene-Cored Galactosylated and Mannosylated Glycodendrimers

Organic Materials, 2023
A prompt and modular copper(I)-catalyzed azide–alkyne cycloaddition ʼclickʼ approach has been exploited for the synthesis of galactose- and mannose-coated calixarene-cored G1 generation glycodendrimers.
Sunil Kumar, Mangal S. Yadav, Tarkeshwar Maddeshiya, Surabhi Asthana, Manoj K. Jaiswal, Vinod K. Tiwari, Mrituanjay D. Pandey   +6 more
doaj   +1 more source

Copper Nanoparticles in Click Chemistry [PDF]

, 2015
Conspectus: The challenges of the 21st century demand scientific and technological achievements that must be developed under sustainable and environmentally benign practices.
Alonso, Francisco, Moglie, Yanina, Radivoy, Gabriel   +2 more
core   +2 more sources