Efficient Synthesis of Azido Sugars using Fluorosulfuryl Azide Diazotransfer Reagent [PDF]
, 2021 Azide-containing sugars are important tools for the synthesis of biologically relevant 1,2-cis-glycosides and for bioconjugation chemistry. Previous strategies for the installation of a non-participating C2-azido functionality use harsh conditions and ...
Matthew S., Macauley +3 more
core +2 more sources
Taming Unhindered Alkyl Azides by Intramolecular Hydrogen-Azide Interaction for Discriminative Conjugation onto Alkyl Diazides [PDF]
, 2021 We report herein the unique reactivities of α-azido secondary acetamides (α-AzSAs) as minimal and unhindered azide structures. The NH–azide interaction in the α-AzSAs, supposed by DFT calculation, allowed selective conjugation in the presence of other ...
Koshiro, Maegawa +5 more
core +2 more sources
Azide-Functionalized Naphthoxyloside as a Tool for Glycosaminoglycan Investigations
, 2021 We present a xylosylated naphthoxyloside carrying a terminal azide functionality that can be used for conjugation using click chemistry. We show that this naphthoxyloside serves as a substrate for β4GalT7 and induces the formation of soluble ...
Roberto Mastio (11715494) +13 more
core +1 more source
Intramolecular Azide to Alkene Cycloadditions for the Construction of Pyrrolobenzodiazepines and Azetidino-Benzodiazepines [PDF]
, 2014 The coupling of proline- and azetidinone-substituted alkenes to 2-azidobenzoic and 2-azidobenzenesulfonic acid gives precursors that undergo intramolecular azide to alkene 1,3-dipolar cycloadditions to give imine-, triazoline- or aziridine-containing ...
O'Gorman, Paul A +11 more
core +1 more source
Azide-Alkyne Click Chemistry over a Heterogeneous Copper-Based Single-Atom Catalyst
, 2022 One-pot three-component regioselective azide-alkyne cycloadditions are central reactions for synthesizing pharmaceuticals and fine chemicals and are also applied for in vivo metabolic labeling biotechnology.
Adam H. Clark (6034265) +23 more
core +1 more source
ChemInform Abstract: Chemical Activation in Azide and Nitrene Chemistry: Methyl Azide, Phenyl Azide, Naphthyl Azides, Pyridyl Azides, Benzotriazoles, and Triazolopyridines [PDF]
ChemInform, 2013 AbstractReview: more than 100 refs.
openaire +2 more sources
, 2022 Fabrication of self-delivery drug systems can surmount low drug bioavailability and achieve a precise therapeutic process. In this study, a hydrogen sulfide-responsive (H2S) small molecule prodrug was synthesized by linking two chemotherapy drugs ...
Mingchuan Xu (11230753) +8 more
core +1 more source
Oligonucleotide Tagging for Copper-Free Click Conjugation
Molecules, 2013 Copper-free click chemistry between cyclooctynes and azide is a mild, fast and selective technology for conjugation of oligonucleotides. However, technology for site-specific introduction of the requisite probes by automated protocols is scarce, while ...
Alan Rowan +7 more
doaj +1 more source
Molecules, 2012 There is considerable attention directed at chemically modifying nucleic acids with robust functional groups in order to alter their properties. Since the breakthrough of copper-assisted azide-alkyne cycloadditions (CuAAC), there have been several ...
Wei Gong +2 more
doaj +1 more source
Designed Monomers and Polymers, 2019 Current solid rocket propellant formulations still employ traditional ingredients utilized since the 1960s, such as hydroxyl terminated polybutadiene (HTPB).
Tianze Cheng
doaj +1 more source