Results 231 to 240 of about 25,600 (309)

Synthesis of enantiomerically enriched β-substituted analogs of (S)-α-alanine containing 1-phenyl-1H-1,2,3-triazole groups. [PDF]

open access: yesAmino Acids
Poghosyan AS   +8 more
europepmc   +1 more source

The Chemistry and Biology of the Tetrodotoxin Natural Product Family

open access: yesAngewandte Chemie International Edition, Accepted Article.
Tetrodotoxin is a neurotoxic marine alkaloid, first isolated in 1909 from pufferfish and named after the biological order tetraodontiformes. Since its structural elucidation in 1964, it has attracted the interest of synthetic organic chemists due to its exceptional polarity, complex architecture, and important biological activity.
Benedikt Nißl   +6 more
wiley   +1 more source

Coordinative Ring‐Opening Polymerization of Limonene Carbamate towards Phosgene‐ and Isocyanate‐Free Polyurethane

open access: yesAngewandte Chemie International Edition, Accepted Article.
This study presents a phosgene‐ and isocyanate‐free route for the synthesis of polyurethanes using (R)‐limonene as a bio‐based starting material. The synthesis of the cyclic limonene‐based carbamate monomer LU is achieved in high yields using dimethyl carbonate as a sustainable, less hazardous phosgene surrogate and is verified by NMR, SC‐XRD, ESI‐MS ...
Jonas Futter   +4 more
wiley   +1 more source

Intriguing Reactivity of a 1,2‐Dihydrodialumane Towards Organic Azides – From a Terminal Diazido–Dialumane to Pendulum‐Clock‐Like Azide Bridging

open access: yesAngewandte Chemie International Edition, EarlyView.
The reaction of a dihydro‐dialane supported by a hybrid ligand (DNI) with organic azides yields structurally diverse aluminium species, including the first example of low oxidation state aluminium azide complex, a diazido‐dialane, along with an aluminium‐tetrazole, and azide alumination.
Xiaobai Wang   +7 more
wiley   +1 more source

Is Phenylnitrene a Missing Link in the Formation of Polycyclic Aromatic Nitrogen Heterocycles?

open access: yesAngewandte Chemie International Edition, EarlyView.
A new formation pathway for polycyclic aromatic nitrogen heterocycles (PANHs) has been found. The reaction of phenylnitrene and the propargyl radical leads to quinoline, proving that nitrenes are suitable precursors for nitrogen incorporation mechanisms.
Rahel Arns   +6 more
wiley   +1 more source

Imaging‐Based High‐Content Screening with Clickable Probes Identifies XPB Inhibitors

open access: yesAngewandte Chemie International Edition, Accepted Article.
High‐content screening (HCS) has become a powerful tool in drug discovery; however, its reliance on indirect readouts and surrogate markers limits HCS’s ability to directly assess drug‐protein interactions at endogenous levels, particularly in subcellular contexts.
Shuqi Li   +10 more
wiley   +1 more source

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