Results 211 to 220 of about 29,936 (297)

Ascorbyl Radicals as Reducing Agents in Copper-Catalyzed Redox Reactions. [PDF]

open access: yesInorg Chem
de Castro CB   +9 more
europepmc   +1 more source

Synthesis and Glycosidase Inhibition Studies of Novel Exoglycals Targeting GH3 Family Enzymes: Insights from Comparative Analysis with Macrolide Antibiotics

open access: yesChemistry – A European Journal, EarlyView.
A series of structurally diverse exoglycals was synthesized using a modified Julia‐olefination approach from sugar‐derived precursors. These glycosidase transition‐state mimics were further diversified via CuAAC chemistry to yield triazole‐conjugated analogues.
Elisa Ospanow   +2 more
wiley   +1 more source

Engineering Bisubstrates to Target m6Am RNA Methyltransferases: Synthesis and Computational Studies

open access: yesChemistry – A European Journal, EarlyView.
Use of the convertible nucleoside approach to synthesize m6Am RNA methyltransferase bisubstrates. This methodology allows for the introduction of modifications on the SAM analog moiety and the RNA substrate part, including the introduction of a cap analog by click chemistry.
Yoann Colas   +3 more
wiley   +1 more source

Photo-Triggered Hyaluronic Acid Hydrogel for 3D Culture and Cell Recovery. [PDF]

open access: yesChembiochem
Palmieri F   +8 more
europepmc   +1 more source

Photocatalytic Vanadium‐Mediated Amination of Benzene With Hydroxylamine

open access: yesChemistry – A European Journal, EarlyView.
Photochemical activation of N‐phenylphenothiazine (PPT) enables a selective direct benzene amination with hydroxylamine in the presence of various vanadium catalysts under mild reaction conditions. Spectroscopic and kinetic analyses identify a key vanadium(IV)‐hydroxylamine intermediate, elucidate the crucial roles of the acidic medium, the ...
Dana Králová   +6 more
wiley   +1 more source

Synthetic Strategies for Activity‐Based Probes to Decode Ubiquitin‐Like Modifiers

open access: yesChemistry – A European Journal, EarlyView.
ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Saibal Chanda   +5 more
wiley   +1 more source

Modular Rh‐Catalyzed Synthesis and Biological Profiling of Diverse Pentafluorobenzenesulfonamide Reactive Fragments

open access: yesChemistry – A European Journal, EarlyView.
A modular Rh‐catalyzed synthetic approach enabled the preparation of diverse reactive fragments from available substrates. The reactive fragments modified Aurora A kinase via several distinct modification reaction classes. In a complex biological environment, the constellation of modified proteins depended critically on the reactive fragment structure.
Julian Chesti   +8 more
wiley   +1 more source

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