Results 221 to 230 of about 18,930 (288)

<i>In Crystallo</i> Synthesis of a Triplet Silver Nitrene. [PDF]

open access: yesJ Am Chem Soc
Roychowdhury P   +6 more
europepmc   +1 more source

Synthesis of a Stable Hydrophilic trans‐Cyclooctene Amino Acid Unlocks Fast Bioorthogonal Click Chemistry for the Generation of Antibody‐Drug Conjugates by Genetic Code Expansion

open access: yesAngewandte Chemie International Edition, EarlyView.
A novel trans‐cyclooctene (TCO) based noncanonical amino acid (ncAA) is reported, characterized by high hydrophilicity and remarkable stability to trans‐cis isomerization. Its incorporation via genetic code expansion into an antibody and subsequent conjugation resulted in a highly efficacious antibody‐drug conjugate (ADC).
Georgi R. Genov   +4 more
wiley   +1 more source

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