Looking for an optimal antihypertensive combination. Focus on azilsartan medoxomil/chlorthalidone [PDF]
Российский кардиологический журналThe article analyzes data from clinical studies on the efficacy and safety of azilsartan medoxomil/chlorthalidone combination and its components. According to the analyzed sources, both individual components and their combination have proven their ...
M. D. Smirnova +2 more
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Central Composite Design Implemented Azilsartan Medoxomil Loaded Nanoemulsion to Improve Its Aqueous Solubility and Intestinal Permeability: In Vitro and Ex Vivo Evaluation [PDF]
Pharmaceuticals, 2022 The present research attempted to design and develop a nanoemulsion formulation of azilsartan medoxomil to improve its aqueous solubility and intestinal permeability. Based on the solubility profile, ethyl oleate, tween 80, and Transcutol P were selected
Girish Kumar +4 more
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Is the newest angiotensin‐receptor blocker azilsartan medoxomil more efficacious in lowering blood pressure than the older ones? A systematic review and network meta‐analysis [PDF]
The Journal of Clinical Hypertension, 2021 Angiotensin‐receptor blockers are often considered insufficiently efficacious in reducing blood pressure. However, newer angiotensin‐receptor blockers may be more effective than the older ones.
Ji‐Guang Wang +6 more
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An alternative synthesis of Azilsartan: an angiotensin II receptor blocker [PDF]
Current Issues in Pharmacy and Medical Sciences, 2015 This paper provides a description of an alternative, novel and commercially viable process which has been developed for the preparation of Azilsartan, a pro-drug of Azilsartan medoxomil, an angiotensin II receptor blocker.
Garaga Srinivas +6 more
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A Prospective Study of Azilsartan Medoxomil in the Treatment of Patients with Essential Hypertension and Type 2 Diabetes in Asia [PDF]
International Journal of Hypertension, 2022 This phase 4 study evaluated the efficacy and safety of azilsartan medoxomil (AZL-M) in patients with essential hypertension and type 2 diabetes mellitus (T2DM) in Hong Kong, Taiwan, and Thailand.
Chaicharn Deerochanawong +4 more
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Efficacy and safety of azilsartan medoxomil/chlortalidone fixed-dose combination in hypertensive patients uncontrolled on azilsartan medoxomil alone: A randomized trial. [PDF]
J Clin Hypertens (Greenwich), 2018 Patients with grade 2‐3 essential hypertension and postplacebo mean clinic systolic blood pressure (SBP) 160‐190 mm Hg and 24‐hour SBP 140‐175 mm Hg by ambulatory blood pressure monitoring (ABPM) received 40 mg azilsartan medoxomil (AZL‐M) monotherapy for 4 weeks.
Collier DJ +7 more
europepmc +5 more sources
Evaluation of the angiotensin II receptor blocker azilsartan medoxomil in African-American patients with hypertension. [PDF]
J Clin Hypertens (Greenwich), 2017 The efficacy and safety of azilsartan medoxomil (AZL-M) were evaluated in African-American patients with hypertension in a 6-week, double-blind, randomized, placebo-controlled trial, for which the primary end point was change from baseline in 24-hour ...
Johnson W +9 more
europepmc +3 more sources
Safety of combination therapy of azilsartan medoxomil and amlodipine: a population-based cohort study [PDF]
Epidemiology and HealthOBJECTIVES This study investigated the safety of azilsartan and amlodipine combination therapy versus other angiotensin receptor blockers (ARBs) and amlodipine in patients with hypertension.
Hyesung Lee +9 more
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Efficacy and safety of azilsartan medoxomil and telmisartan in hypertensive patients: A randomized, assessor-blinded study [PDF]
Saudi Journal of Medicine and Medical Sciences, 2020 Background: Few studies have compared the safety and efficacy of azilsartan medoxomil (AZL-M) and telmisartan in hypertensive patients, especially using ambulatory blood pressure monitoring (ABPM).
Megha Garg +5 more
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A randomized trial of the efficacy and safety of azilsartan medoxomil combined with chlorthalidone. [PDF]
J Renin Angiotensin Aldosterone Syst, 2018 INTRODUCTION: We measured the effects of azilsartan medoxomil co-administered with chlorthalidone 25 mg in stage 2 hypertension. METHODS: Azilsartan medoxomil 40 or 80 mg plus chlorthalidone were compared with placebo plus chlorthalidone once daily in a ...
Weber MA +4 more
europepmc +3 more sources