Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges. [PDF]
NeuroprotectionAntimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Manavi MA +5 more
europepmc +2 more sources
Azithromycin Exhibits Activity Against Pseudomonas aeruginosa in Chronic Rat Lung Infection Model
Frontiers in Microbiology, 2021 Pseudomonas aeruginosa forms biofilms in the lungs of chronically infected cystic fibrosis patients, which are tolerant to both the treatment of antibiotics and the host immune system.
Manoj Kumar +11 more
doaj +1 more source
Dry Powder Formulation of Azithromycin for COVID-19 Therapeutics [PDF]
, 2023 Aim: The aim of this study is to develop dry powder formulations of azithromycin-loaded poly(lactic-co-glycolic acid) (PLGA) nanocomposite microparticles for pulmonary delivery to improve the low bioavailability of azithromycin.
Somavarapu, Satyanarayana +3 more
core +1 more source
Azithromycin plus chloroquine: combination therapy for protection against malaria and sexually transmitted infections in pregnancy. [PDF]
, 2011 INTRODUCTION: The first-line therapy for the intermittent preventive treatment of malaria in pregnancy (IPTp) is sulphadoxine-pyrimethamine (SP).
Chandramohan, Daniel +3 more
core +1 more source
Science and Technology Indonesia, 2023 Azithromycin is a narrow-spectrum bacterial growth inhibitory antibiotic derived from macrolides with low dissolution in water. Several methods have been carried out to increase the dissolution of medicinal substances, one of which is solid dispersion ...
Mardiyanto +3 more
doaj +1 more source
EFFICACY OF AZITHROMYCIN ON EXPERIMENTAL TOXOPLASMOSIS INFECTED MICE [PDF]
Journal of the Egyptian Society of Parasitology, 2020 Toxoplasma gondii is an opportunistic protozoan that causes a devastating disease in immunocompromisedindividuals and congenitally infected neonates or children.
GEHAN A. RASHED +7 more
doaj +1 more source
On the pathway to better birth outcomes? A systematic review of azithromycin and curable sexually transmitted infections. [PDF]
, 2013 The WHO recommends the administration of sulfadoxine-pyrimethamine (SP) to all pregnant women living in areas of moderate (stable) to high malaria transmission during scheduled antenatal visits, beginning in the second trimester and continuing to ...
Chandramohan, Daniel +9 more
core +1 more source
Microbiology Spectrum, 2021 In this study, an IncI1 plasmid encoding resistance to both cefotaxime and azithromycin was recovered from a clinical Klebsiella pneumoniae strain. The azithromycin resistance was confirmed to be mediated by the erm(B) gene. This plasmid could be readily
Xuemei Yang +5 more
doaj +1 more source
A cluster-randomized controlled trial evaluating the effects of mass azithromycin treatment on growth and nutrition in Niger. [PDF]
, 2012 Antimicrobials are used primarily to treat infectious disease, but they have other effects. Here, we assess anthropometry measurements in children 6-60 months in 24 communities randomized to one or two mass azithromycin distributions over a 1-year period
Lietman, Thomas +25 more
core +1 more source
SVU - International Journal of Medical Sciences, 2022 Background: Azithromycin is one of the most common drugs used in the protocol of treatment of pneumonia caused by COVID-19. But many researchers approved its toxicity on heart tissue.
Abeer F. Abd El-Naeem +2 more
doaj +1 more source