Results 101 to 110 of about 56,531 (323)

Spectrum of activity and mechanisms of azole–bisphosphonate synergy in pathogenic Candida

open access: yesMicrobiology Spectrum
Candidiasis places a significant burden on human health and can range from common superficial vulvovaginal and oral infections to invasive diseases with high mortality.
Aidan Kane   +5 more
doaj   +1 more source

Navigating Solute Carrier Transporters—A Comprehensive Review of Functionalized Small Molecule Probes for Target Identification and Characterization

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT Solute carrier transporters (SLCs) are integral membrane proteins that play pivotal roles in maintaining cellular homeostasis by mediating the transport of a diverse range of substrates across cell membranes. With their involvement in fundamental physiological processes such as nutrient uptake, neurotransmitter signaling, and drug transport ...
Majlen A. Dilweg   +3 more
wiley   +1 more source

Treatment of Aspergillosis. [PDF]

open access: yes, 2018
Infections caused by Aspergillus spp. remain associated with high morbidity and mortality. While mold-active antifungal prophylaxis has led to a decrease of occurrence of invasive aspergillosis (IA) in those patients most at risk for infection ...
Hoenigl, Martin, Jenks, Jeffrey D
core   +1 more source

Epidemiological and genomic landscape of azole resistance mechanisms in Aspergillus fungi

open access: yesFrontiers in Microbiology, 2016
Invasive aspergillosis is a life-threatening mycosis caused by the pathogenic fungus Aspergillus. The predominant causal species is Aspergillus fumigatus, and azole drugs are the treatment of choice.
Daisuke Hagiwara   +3 more
doaj   +1 more source

A Computational Study of the NMR Chemical Shifts of Polynitropyrazoles

open access: yesMagnetic Resonance in Chemistry, EarlyView.
The 1H, 13C, 15N, and 17O chemical shifts of 91 nitro‐1H‐pyrazoles at GIAO/B3LYP/6‐311++G(d,p) level. The calculated chemical shifts were compared with available experimental data using an empirical equation that relates absolute shieldings to chemical shifts.
Arturo Alcorta   +3 more
wiley   +1 more source

In vitro biofilms and antifungal susceptibility of dermatophyte and non-dermatophyte moulds involved in foot mycosis [PDF]

open access: yes, 2017
Tinea pedis and onychomycosis are among the commonest fungal diseases in the world. Dermatophytes and, less frequently, non-dermatophyte moulds are aetiological agents of foot mycosis and are capable of forming biofilms.
Bougnoux, Marie Élisabeth   +5 more
core   +1 more source

One‐Pot Four‐Component Synthesis of Novel Amino‐Tetrahydro‐Chromene Derivatives Anchored with Dual Triazole Moieties

open access: yesChemistryOpen, EarlyView.
A series of tetrahydrochromene derivatives bearing triazole rings is synthesized via a one‐pot reaction. The process is optimized by ultrasonication of a basic aqueous tert‐butanol mixture. Subsequently, the optimized steps are successfully integrated into a four‐component, one‐pot protocol. The whole process was completed in less than 2 h.
Saeede Azhari   +2 more
wiley   +1 more source

Azole antifungal contaminants disrupt mycorrhizal function and risk agricultural sustainability

open access: yesPLANTS, PEOPLE, PLANET, EarlyView.
Global food production is increasingly threatened by soil degradation, climate change and the rising costs of synthetic fertilisers. Circular agriculture, which promotes resource reuse, is a promising solution, but using treated wastewater and biosolids in farming introduces risks from emerging contaminants like pharmaceutical residues.
Emily K. Durant   +5 more
wiley   +1 more source

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