Results 141 to 150 of about 33,379 (274)

Impact of Letermovir on Voriconazole Concentrations in Lung Transplant Patients

Transplant Infectious Disease, EarlyView.
Concomitant letermovir was associated with lower voriconazole exposure and reduced attainment of commonly used efficacy thresholds in lung transplant recipients. Routine therapeutic drug monitoring after letermovir initiation is recommended, and empiric voriconazole dose escalation may be needed to avoid subtherapeutic exposure. ABSTRACT Background The
Leah Georgiades, Sunish Shah, Erin K. McCreary, Fernanda Silveira, Raman Venkataramanan, Vignesh Vasudevan, Ryan M. Rivosecchi   +6 more
wiley   +1 more source

Invasive Fungal Infections in Heart Transplants: A 10‐Year, Single Centre Retrospective Cohort Study From Subtropical Australia

Transplant Infectious Disease, EarlyView.
In this 10‐year retrospective cohort study of heart transplant recipients in subtropical Australia, we characterize the incidence and microbiological profile of invasive fungal infections, highlighting the underappreciated burden of late‐onset and non‐Aspergillus mold infections and the potential underdiagnosis of polymicrobial disease.
Angus Lane, Karen Hay, John McNamara, Alex Chaudhuri, Andrew Burke, Robert Horvath, Maryam Khorramshahi Bayat, Kanthi Vemuri   +7 more
wiley   +1 more source

A Randomised Placebo‐Controlled Study to Evaluate the Efficacy and Safety of a Two‐Dose Topical Terbinafine and Betamethasone Gel for the Treatment of Yeast (Malassezia pachydermatis) Otitis Externa in Dogs

Veterinary Dermatology, EarlyView.
Background: Otitis externa (OE) with Malassezia pachydermatis overgrowth with limited bacterial involvement is common in dogs. Treatment with products containing antibiotics is unnecessary and not consistent with judicious use of antimicrobials.
Zorica Zivkovic Baks, Hope Baird Heinz, Stephan Grundke, Caryn Thompson, Roberto Garcia   +4 more
wiley   +1 more source

Treatment of Canine Atopic Dermatitis: Updated Guidelines From the International Committee on Allergic Diseases of Animals (ICADA)

Veterinary Dermatology, EarlyView.
ABSTRACT Background Canine atopic dermatitis (cAD) is a genetically, aetiologically, immunologically and clinically complex disease requiring both individualised immediate and long‐term management. Objectives These updated guidelines from the International Committee on Allergic Diseases of Animals (ICADA) aim to substantially revise previous ...
Ralf S. Mueller, Frane Banovic, Emmanuel Bensignor, Domenico Santoro, Tim Nuttall   +4 more
wiley   +1 more source

Epidemiological Characteristics of Clinical <i>Aspergillus</i> Section <i>Nigri</i> and Mutations in <i>cyp51A</i> Gene. [PDF]

J Fungi (Basel)
Zhang Y, Zhang Y, Wang S, Zhou C, Pan J, Guo W, Hu B.   +6 more
europepmc   +1 more source

Exploration of novel mechanisms of azole resistance in Candida auris.

Candida auris is a pathogenic yeast of particular concern because of its ability to cause nosocomial outbreaks of invasive candidiasis (IC) and to develop resistance to all current antifungal drug classes. Most C. auris clinical isolates are resistant to
Brandalise, D., Coste, A.T., Lamoth, F., Li, J., Sanglard, D.   +4 more
core   +1 more source

Diethylene Glycol‐Linked Ring‐Fused Bis‐Azoles: Target‐Oriented Synthesis, In Silico Screening, and Antitumor Activity

ChemMedChem, Volume 21, Issue 19, 14 October 2026.
A series of diethylene glycol‐linked cyclic derivatives with diversity in the heterocyclic motif have been synthesized and screened for antitumor activity. Two bis‐thiazolo[3,2‐a]pyrimidinone derivatives displayed moderate cytotoxicity, high selectivity against hepatocellular carcinoma cells, promising VEGFR2, and remarkable FGFR2 inhibitory activities
Sami A. Al‐Hussain, Abdulrahman S. Alharbi, Zeinab A. Muhammad, Alyaa S. Abdel Halim, Magdi E. A. Zaki, Mark C. Bagley, Refaie M. Kassab   +6 more
wiley   +1 more source

Functional characterization of SHC-like triterpene cyclase genes in azole response and virulence-related traits of <i>Aspergillus fumigatus</i>. [PDF]

Virulence
Ye K, Chen F, Hu L, Han J, Li D, Hu M, Wang C, Zeng J, Han L.   +8 more
europepmc   +1 more source

Exploring the Cosmeceutical Potential of Six Malaysian Indigenous Tropical Fruit Trees: Radical Scavenging, Anti‐Tyrosinase, and Photoprotective Activities Evaluation

Chemistry &Biodiversity, Volume 23, Issue 10, October 2026.
B. macrophylla leaf ethyl acetate fractionated extract exhibits the highest TPC, very strong radical‐scavenging activities, and the highest SPF value of 28.64 ± 0.51. LC‐MS analysis identifies m‐trigallic acid, cis‐coutaric acid, and ellagic acid, which may contribute to its bioactivities. The present work highlights B.
Wei Lee Chong, Zhi Ning Teoh, Nurul Ainanajwa Ramli, Sugumaran Manickam, Siew Huah Lim, Chun Hoe Tan, Kae Shin Sim, Hazwani Mat Saad   +7 more
wiley   +1 more source

Comment on "Accuracy of CYP3A5 Pharmacogenomics Recommended Dosing of Tacrolimus with Concomitant Azole Antifungals Early Post-Lung Transplant". [PDF]

Clin Transplant
Pandey P, Mishra AK, Singh S.
europepmc   +1 more source